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  1. 4381
    “…RESULTS: Both methanol and ethanol extracts significantly inhibited the growth and induced apoptosis of MDA-MB-231 cells in a dose-dependent manner. Erythronium japonicum extracts inhibited the adhesion of MDA-MB-231 cells. …”
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    Inhibitory effect of Erythronium japonicum on the human breast cancer cell metastasis
  2. 4382
    “…RESULTS: Animals pretreated with GC extract showed a significant reduction in ulcer score, ulcer index, gastric volume, and gastric total acidity in indomethacin-induced ulcer models in a dose dependent manner when compared to the ulcerated control group. …”
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    Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats
  3. 4383
    “…Results showed that fulvestrant suppressed GH3 cell proliferation and reduced hormone secretion in a dose-dependent manner. Estrogen receptor α and Wnt4 expression decreased, but Wnt inhibitory factor-1 expression increased in a dose-dependent manner following fulvestrant treatment, and β-catenin expression remained unchanged. …”
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    Effects of fulvestrant on biological activity and Wnt expression in rat GH3 cells☆
  4. 4384
    “…Synthetic functional multilayers of molecules cooperating in a coupled manner can be fabricated on surfaces through layer-by-layer self-assembly. …”
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    Coupled Molecular Switching Processes in Ordered Mono- and Multilayers of Stimulus-Responsive Rotaxanes on Gold Surfaces
  5. 4385
    “…Molecules that were identified in this manner seeking cyclic mononucleotide cyclases in plants are used as examples. …”
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    Conserved Functional Motifs and Homology Modeling to Predict Hidden Moonlighting Functional Sites
  6. 4386
    “…Linezolid inhibited mitochondrial proteins in an exposure-dependent manner, with toxicity being driven by trough concentrations. …”
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    Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy
  7. 4387
    “…On addition of Bcl-2 targeting BH3 mimetics, mito-primed cells undergo apoptosis in a rapid and synchronous manner. Using this method we have comprehensively surveyed the efficacy of BH3 mimetic compounds, identifying potent and specific MCL-1 inhibitors. …”
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    Mito-priming as a method to engineer Bcl-2 addiction
  8. 4388
    por Kim, Han Bit, Yoo, Byung Sun
    Publicado 2016
    “…However, the neurite outgrowth of the differentiating SH-SY5Y cells treated with propolis (0.3~3 μg/mL) for 48 hr was significantly inhibited in a dose-dependent manner. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.3 to 3 μg/mL propolis resulted in decreased level of transglutaminase and 43-kDa growth-associated protein (GAP-43) in a dose-dependent manner. …”
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    Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells
  9. 4389
    “…We show here, using a constitutively active Raf (ca-Raf), that Raf-Erk activation in NSCs induces neuronal differentiation in a cell-autonomous manner. By contrast, it causes NSC proliferation and the formation of astrocytes in an extrinsic autocrine/paracrine manner. …”
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    Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation
  10. 4390
    “…In gastric cancer cells, oridonin treatment inhibited cell proliferation in a concentration-dependent manner and down-regulated the expression of p53 downstream genes, whereas p53 inhibition by PFT-α reversed the antiproliferative effects of oridonin. …”
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    Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms
  11. 4391
    “…These results demonstrate that different reading profiles modulate the access to morphological information in a qualitatively different manner and that individual differences in reading determine the manner in which polymorphemic words are processed.…”
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    Not Everybody Sees the Ness in the Darkness: Individual Differences in Masked Suffix Priming
  12. 4392
    “…In our present study, we demonstrate that wild grape wine powder (WGWP) induced relaxation of aortic rings preconstricted with norepinephrine in a dose-dependent manner (at concentrations ranging from 0.1 to 1 mg/mL). …”
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    Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta
  13. 4393
    “…Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC(50) value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. …”
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    Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K(+) channels in coronary arterial smooth muscle cells
  14. 4394
    “…Menin is an enigmatic protein that displays unique ability to either suppress or promote tumorigenesis in a context-dependent manner. The role for Menin to promote oncogenic functions has been largely attributed to its essential role in forming the MLL methyltransferase complex, which mediates H3K4me3. …”
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    Menin enhances c-Myc-mediated transcription to promote cancer progression
  15. 4395
    “…DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner in vitro and in vivo. Finally, the antitumor activity of DP6 against B16F1 melanoma cells was inhibited in NK cell-depletion systems by using NK-cell depleting antibodies in vivo. …”
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    Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity
  16. 4396
    “…From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.…”
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    Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K(+) channels in coronary arterial smooth muscle cells
  17. 4397
    “…Enzymatic kinetics also demonstrated that clomifene inhibited mutant enzyme in a non-competitive manner. Moreover, knockdown of mutant IDH1 in HT1080 cells decreased the sensitivity to clomifene. …”
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    Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1
  18. 4398
    “…The possibility of detecting and classifying living cells in a label-free and non-invasive manner holds significant theranostic potential. In this work, Hyperspectral Imaging (HSI) has been successfully applied to the analysis of macrophagic polarization, given its central role in several pathological settings, including the regulation of tumour microenvironment. …”
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    Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis
  19. 4399
    “…Here, we show that endogenous Wnt8 protein is distributed in a graded manner in Xenopus embryo and accumulated on the cell surface in a punctate manner in association with “N-sulfo-rich heparan sulfate (HS),” not with “N-acetyl-rich HS”. …”
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    Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
  20. 4400
    “…In an EGFR-dependent manner, acquired mutations, such as T790 M, interferes the interaction between TKIs and the kinase domain of EGFR. …”
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    EGFR-TKIs resistance via EGFR-independent signaling pathways
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