“…The long-term administration of GSPE together with an obesogenic diet expanded rWAT via an increase in the adipocyte number and a preventive decrease in the adipocyte size in a dose-dependent manner. At the molecular level, GSPE seems to induce WAT adipogenesis through the upregulation of peroxisome proliferator-activated receptor (Pparγ) in a Sirtuin 1 (Sirt1)-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The results suggested that DFO significantly inhibited K562 cell viability and induced cell apoptosis in a dose-dependent manner. We also found that the protein and mRNA levels of Bax, p53, and Fas dose-dependently increased in DFO-treated K562 cells, while the level of Bcl-2 markedly decreased in a dose-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We disclose the most likely binding site of P5091 (a potent USP7 inhibitor), which reveal a cryptic allosteric site through extensive computational studies in an inhibitor dependent and independent manner. Overall, these findings demonstrate the tractability and druggability of USP7. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A high index of suspicion for acute pancreatitis is necessary in patients with DKA, especially with co-existing hypertriglyceridemia; and all efforts should be made to diagnose it in a timely manner to prevent subsequent complications.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also emphasize the role of miRNAs in controlling the epithelial–mesenchymal transition of CRC cells, a process responsible for liver metastasis in a circulating tumor cell-dependent manner. Furthermore, we discuss the role of miRNAs transported by CRC-derived exosomes in mediating liver metastases, by preparing the secondary pre-metastatic niche and in inducing liver carcinogenesis in a Dicer-dependent manner.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results revealed that CFTs can regulate serum lipid levels in hyperlipidemic rats in a dosage-dependent manner. Synchronously, gene expressions related to cholesterol excretion were upregulated in a dosage-dependent manner, including cholesterol 7α-hydroxylase (CYP7A1), liver X receptor α (LXRA), peroxisome proliferation-activated receptor-α (PPARα) and low-density lipoprotein receptor (LDLR), whereas cholesterol synthetic gene expressions including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) were reduced. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The SLCN showed a higher inhibition of nitric oxide (NO) production compared to conventional curcumin in a dose-dependent manner. Similarly, the mRNA and proinflammatory cytokine levels were also reduced in a dose-dependent manner when compared to those with free curcumin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data urges strong caution when interpreting the phenotypic impact of gene responses using αMHC-cre mice, since a lethal DCM was induced by the cre driver in an age-dependent manner in this commonly utilized model system.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Combining use of PHN and autophagy blockers including 3-methyladenine (3-MA) and chloroquine (CQ) significantly inhibited HEp-2 cell proliferation in a dose- and time-dependent manner and induced apoptosis after 24 h in a dose-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results highlight the biological necessity to analyze nutrient deficiency responses in a tissue- rather organ-specific manner.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All species, including humans, are cohabited by a myriad of microbial species, which massively influences body function in a diet‐, exercise‐ and age‐dependent manner. The microbiome composition differs between individuals, partly due to the polymorphic immune system, as well as the environment, making the microbe–host interplay unique in each one of us. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The SRP views research translation as communicating and facilitating the use of research findings emanating from the center in a manner most appropriate for their application and for the advancement of a center’s research objectives. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The surface expression of CA12 and AE2 were decreased by Disulfiram treatment with a time-dependent manner. Disulfiram treatment did not alter the expression of Na(+)-bicarbonate cotransporters, nor did it affect autophagy regulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Exosomes, the nanosized vesicles released from various cell types, contain many bioactive molecules, such as proteins, lipids, and nucleic acids, which can participate in intercellular communication in a paracrine manner or an endocrine manner, in order to maintain the homeostasis and respond to stress adaptively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, eHEPOs are excellent unlimited cell sources to generate functional hepatic organoids in a fast and efficient manner.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that ICA could enhance BMP2-mediated osteoblastic differentiation of C2C12 cells in a dose-dependent manner. Treatment with ICA activated the cAMP/PKA/CREB signaling axis in a time-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PGG suppressed PAK1 and JNK1 kinase activities, and directly bound both PAK1 in an ATP-competitive manner and JNK1 in an ATP-noncompetitive manner. Consistently, PGG decreased UVB-induced wrinkle formation, epidermal thickness, type 1 collagen and MMP-13 expression in mouse skin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: The nurse researcher needs to be highly skilled in this approach as it requires the ability to implement the specific play therapeutic approach in a safe and skilful manner.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The classification network is a combination of stacked autoencoders trained in an unsupervised manner and multilayer perceptrons trained in a supervised manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Protein import across the endoplasmic reticulum membrane is physiologically regulated in a substrate-selective manner to ensure the protection of stressed ER from the overload of misfolded proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso