“…Each topic has been introduced and developed in simple and straightforward manner. The fundamental principles involved have been amply illustrated by diagrams and worked out examples. …”
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“…The resulting model is able to describe elastic $pp$ scattering not only at the lower ISR energies but also at $\sqrt{s}=$7~TeV in a statistically acceptable manner, both in the diffractive cone and in the region of the first diffractive minimum. …”
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“…We show how the photon parton distribution function (PDF) can be determined in a model-independent manner, using electron-proton ($ep$) scattering data, in effect viewing the $ep\to e+X$ process as an electron scattering off the photon field of the proton. …”
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“…A general procedure is detailed for integrating-out the fluctuations as to obtain the effective transport equations for the mean fields. In this manner, collision integrals for Boltzmann equations are obtained as correlators of fluctuations. …”
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“…Employing the SU(2) isospin symmetry of strong interactions and estimates borrowed from effective field theory, we explore the impact of new physics on the decays $B^\pm\to \phi K^\pm$ and $B_d\to \phi K_S$ in a model-independent manner. To this end, we introduce - in addition to the usual mixing-induced CP asymmetry in $B_d\to \phi K_S$ - a set of three observables, which may not only provide smoking-gun signals for new-physics contributions to different isospin channels, but also valuable insights into hadron dynamics. …”
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“…The amplitudes are extracted in a scheme-independent manner from the coefficients appearing in the general tensorial structure for this process. …”
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“…Therefore, it would be ideal to allow continuous and simultaneous direct phenotypic monitoring of both SNs and astrocytes in a high-to-moderate throughput non-invasive manner and would significantly advance the field of electrophysiology. …”
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“…Collectively, these results suggest the possibility to activate CD40 in a PDGFRB-targeted manner in vitro. This encourages further investigation and the development of such an approach for the treatment of solid cancers.…”
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“…Ameliorative action would extend from training in death certification to routine use of psychological autopsies in equivocal-manner-of-death cases.…”
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“…Overexpression of β-catenin or Slug could upregulate L1CAM expression in a cell-type specific manner. CONCLUSIONS: Our results, for the first time, provide evidence that the L1CAM gene has two functionally active promoter sites that are used in a cell-type specific manner. …”
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“…Using phospho-specific antibodies and luciferase reporter assays, we further demonstrate that H. pylori induces IRAK-1 and IκB phosphorylation in a TLR-dependent manner, and this was required for activation of transcription factor NF-κB. …”
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“…RESULTS: Our data provide the first evidence that IGF-1R signaling regulates LIP expression in an EGFR independent manner to increase the LIP/LAP ratio in mammary epithelial cells. …”
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“…Resveratrol increased PTEN, Akt and mTOR phosphorylation in a dose-dependent manner or a time-dependent manner. Rapamycin (10 nM), a specific mTOR inhibitor, blocked the effects of resveratrol on LPS-induced microglial activation. …”
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“…Thus, whereas both mTORC1 and mTORC2 are activated in a PI3K-dependent manner, different additional signaling pathways are needed. mTORC1 is activated in a PLD-dependent manner and promotes phosphorylation of the S6 protein, whereas mTORC2, in concert with PLCγ signaling, promotes Akt phosphorylation.…”
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“…Finally, shifts in the emission spectra of an environmentally sensitive fluorescent unnatural amino acid indicate that the calcium binding loops of the C2F domain directly interact with the lipid bilayer of negatively charged liposomes in a calcium-independent manner. On the basis of these results, we propose that the C2F and C2C domains of otoferlin preferentially bind PI(4,5)P2 and that PI(4,5)P2 may serve to target otoferlin to the presynapse in a calcium-independent manner. …”
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“…There is a great need for a valid and reliable diagnostic tool to aid clinicians in arriving at the diagnoses in a timely and accurate manner. Prior studies have suggested that patients suffering from schizophrenia and ADHD may process certain sound stimuli in the brainstem in an unusual manner. …”
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“…Department directors need to be trained on providing peer evaluation feedback in a constructive manner.…”
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“…BACKGROUND: Viral vectors are frequently used to deliver and direct expression of transgenes in a spatially and temporally restricted manner within the nervous system of numerous model organisms. …”
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“…RESULTS: Treatment with MERL significantly inhibited growth of AGS cells in a concentration dependent manner. MERL treatment in AGS cells leaded to increased accumulation of apoptotic sub G1 phase cells in a concentration dependent manner. …”
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“…While previous studies have identified several cellular proteins that may function at early steps of infection in a cell type dependent manner, the mechanism of virus entry is still poorly understood. …”
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