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  1. 4701
    “…On the contrary, rotenone and complex I inhibition mostly affect the ARPE-19 paracellular resistance R(b) in a dose-dependent manner compared to basolateral resistance α or C(m). …”
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    Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases
  2. 4702
    “…Conclusion: Arabidopsis physiological adaptation to spaceflight results in differential DNA methylation in an organ-specific manner. Disruption of Met1 methyltransferase function does not dramatically affect spaceflight growth or morphology, yet met1-7 reprograms the spaceflight transcriptomic response in a unique manner. …”
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    Epigenomic Regulators Elongator Complex Subunit 2 and Methyltransferase 1 Differentially Condition the Spaceflight Response in Arabidopsis
  3. 4703
    “…Medicago denticulata significantly increased the discrimination index in a dose-dependent manner using novel object recognition test (NORT) model. …”
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    Evaluation of analgesic, antiamnesic and antidiarrheal potentials of Medicago denticulata extract using animal model
  4. 4704
    “…Mp also induced the production of inflammatory cytokines and chemokines in the BALF in a toll-like receptor 2 (TLR2)-dependent manner. Particularly, both interleukin (IL)-1α and IL-12 p40 played a crucial role in neutrophil infiltration into the BALF in a coordinated manner. …”
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    Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice
  5. 4705
    por Wark, Jason David
    Publicado 2022
    “…Although new digital tools are making behavior monitoring more accessible, analyzing behavior data in a timely manner to draw meaningful insights can be challenging. …”
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    Power Up: Combining Behavior Monitoring Software with Business Intelligence Tools to Enhance Proactive Animal Welfare Reporting
  6. 4706
    por Al-Romaiyan, Altaf, Masocha, Willias
    Publicado 2022
    “…Pristimerin inhibited both mouse brain and paw skin MAGL activity in a concentration-dependent manner. Paclitaxel induced mechanical allodynia and increase in MAGL activity in the paw skin. …”
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    Pristimerin, a triterpene that inhibits monoacylglycerol lipase activity, prevents the development of paclitaxel-induced allodynia in mice
  7. 4707
    “…OP-D consistently inhibited the phosphorylation of AKT expression in a dose-dependent manner. Furthermore, OP-D shortened c-Myc’s half-life in a time-dependent manner. …”
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    Ophiopogonin D increase apoptosis by activating p53 via ribosomal protein L5 and L11 and inhibiting the expression of c-Myc via CNOT2
  8. 4708
    “…This time, despite the world problems due to SARSCOV2 pandemic, which causes the Covid’19 diseases, the Universidad Autónoma Chapingo through the Coordinación de Revistas Institucionales, has been trying to comply with the publication of institutional journals in a timely manner and working via online.…”
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    Forward Revista Geografía Agrícola number 65
  9. 4709
    “…. • Cotyledonoid dissecting leiomyoma presents in a similar manner as aggressive malignancies; however, it is a benign lesion. • Recurrence of cotyledonoid dissecting leiomyoma is exceedingly rare with only one documented recurrence following conservative treatment.…”
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    Cotyledonoid dissecting leiomyoma with adipocytic differentiation: A case report()
  10. 4710
    “…Health systems investing in this technology will need to build infrastructure and develop policies that ensure genomic information can be generated, shared and acted upon in a timely manner.…”
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    Moving pathogen genomics out of the lab and into the clinic: what will it take?
  11. 4711
    “…A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.…”
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    A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
  12. 4712
    “…In our paediatric service, referrals for young people with chronic health problems significantly increased in times of acute stress, for example, during exams, and offering support in a timely manner was often a challenge. In order to respond more efficiently to this increase, a group intervention was introduced.…”
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    Quality improvement project aimed at integrating an adapted mindfulness-based stress reduction programme into a paediatric psychology service
  13. 4713
    “…Virtual pump training program for novel devices in people with type 1 diabetes on multiple daily injections can be an effective tool to initiate an advanced HCL system (MiniMed 780G) and to improve glycemic control in a safe manner without severe hypoglycemia and hyperglycemia.…”
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    Virtual training on advanced hybrid closed‐loop system MiniMed 780G in a teenager with type 1 diabetes previously treated with multiple daily injections: A case report
  14. 4714
    “…The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.…”
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    Efficient and sustainable laccase-catalyzed iodination of p-substituted phenols using KI as iodine source and aerial O(2) as oxidant
  15. 4715
    “…We built a common standard infrastructure with a fit-for-purpose strategy to bring together health-related data and ease the work of both data providers to supply data in a standard manner and researchers by enhancing the quality of the collected data. …”
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    FAIRification of health-related data using semantic web technologies in the Swiss Personalized Health Network
  16. 4716
    “…The difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests, combined with the risk of serious consequences if EONS is not treated in a timely manner, has resulted in a low threshold for starting empirical antibiotic treatment. …”
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    Group B Streptococcus Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use
  17. 4717
    “…Compared to sighted people, blind people's speech focused more on path and less on manner of motion, and encoded paths in a more segmented fashion using more landmarks and path verbs. …”
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    Lack of Visual Experience Affects Multimodal Language Production: Evidence From Congenitally Blind and Sighted People
  18. 4718
    “…Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. …”
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    RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
  19. 4719
    “…Together, our data reveal that astrocytes contact and eliminate synapses in a C1q-dependent manner and thereby contribute to pathological synapse loss and that astrocytic phagocytosis can compensate for microglial dysfunction.…”
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    Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
  20. 4720
    “…Compound 1 emerged as the most effective PROTAC being nontoxic up to 20 μM to neuronal cells and already able to degrade GSK-3β starting from 0.5 μM in a dose-dependent manner. PROTAC 1 significantly reduced the neurotoxicity induced by Aβ(25–35) peptide and CuSO(4) in SH-SY5Y cells in a dose-dependent manner. …”
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    PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease
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