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  1. 4781
    “…We have developed an innovative strategy that maps enhancers to genes in a principled manner. We illustrate its power by applying it to Myrf. …”
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    A principled strategy for mapping enhancers to genes
  2. 4782
    “…The termination of pre-mRNA splicing functions to discard suboptimal substrates, thereby enhancing fidelity, and to release excised introns in a manner coupled to spliceosome disassembly, thereby allowing recycling. …”
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    Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6
  3. 4783
    por Lee, Choogon
    Publicado 2019
    “…Because CRYs oscillate, they act in a circadian manner resulting in daily oscillations in Cop1 substrates and the downstream pathways that they regulate. …”
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    CRY arrests Cop1 to regulate circadian rhythms in mammals
  4. 4784
    “…Immune pathways offer a wide array of tightly regulated genes that can be repurposed to express potent functionalities in a highly controlled manner. Here, we explore this concept by repurposing TCR, CD25 and PD1, three major players of the T cell activation pathway. …”
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    Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
  5. 4785
    “…Restricting these conformational changes blocked docking in an intermediate filament-dependent manner. These data demonstrate that a host-induced conformational change to the pore enables T3SS docking and effector secretion, providing new mechanistic insight into the regulation of type 3 secretion.…”
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    Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore
  6. 4786
    “…This system controls the canonical WNT/β-catenin pathway in a positive manner, and PPARγ in a negative manner. The WNT/β-catenin pathway promotes fibrosis, while PPARγ prevents it. …”
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    TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts
  7. 4787
    “…This inhibition of replication is associated with a rapid shutoff of new viral RNA synthesis, in a manner similar to that seen in the presence of cycloheximide. …”
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    Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d
  8. 4788
    “…The DNA-demethylating agent decitabine recovers FBXL7 expression and limits epithelial-to-mesenchymal transition and cell invasion in a c-SRC-dependent manner. In vivo, FBXL7-depleted cancer cells form tumors with high metastatic burden. …”
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    Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
  9. 4789
    “…Both exploratory and confirmatory factor analyses are used in a step-wise manner for scale development. Reliability and validity are evaluated. …”
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    Online Artículo Texto
    Supply chain viability: conceptualization, measurement, and nomological validation
  10. 4790
    “…We study two models: a pessimistic model where flows interfere in a worst-case manner along equal-cost shortest paths, and an optimistic model where flows are routed in a best-case manner, and we present a complete picture of the algorithmic complexities. …”
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    Resilient Capacity-Aware Routing
  11. 4791
    “…In addition, sRNAs can either co-occupy Hfq with the mRNA as a ternary complex, or displace the mRNA from Hfq in a binding face-dependent manner, suggesting mechanisms through which sRNAs rapidly access Hfq to induce sRNA-mediated gene regulation. …”
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    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells
  12. 4792
    “…This work investigates the ability to classify misinformation in online social media networks in a manner that avoids the need for ground truth labels. …”
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    Classification of unlabeled online media
  13. 4793
    “…Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture and immunity. …”
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    Structural basis of the human Scribble–Vangl2 association in health and disease
  14. 4794
    “…The idea that misfolded TDP-43 spreads in a prion-like manner between cells may guide novel therapeutic strategies for TDP-43-associated neurodegenerative diseases.…”
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    The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
  15. 4795
    “…UPF1-induced oxaliplatin resistance can be associated with interaction between zinc finger of UPF1 and Toprim of TOP2A and increasing phosphorylated TOP2A in a SMG1-dependent manner. Moreover, UPF1 maintains stemness in a TOP2A-dependent manner in CRC. …”
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    UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer
  16. 4796
    “…SRMS is amplified and overexpressed in human cancers where it drives unrestrained AKT signaling in a kinase-dependent manner. SRMS kinase inhibition activates autophagy, inhibits cancer growth, and can be accomplished using the FDA-approved tyrosine kinase inhibitor ibrutinib. …”
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    The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51
  17. 4797
    “…With older children, parents use a passive manner by omitting restrictive responses to their children’s media use. …”
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    A Qualitative Study on Children’s Digital Media Use and Parents’ Self-interest
  18. 4798
    “…Based on our results, increases in three phytochemical contents were observed, in a PH concentration-dependent manner (0–0.01 mg/mL). Similar trends were also observed for chlorophyll and carotenoid contents. …”
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    Application of enzyme-digested soy protein hydrolysate on hydroponic-planted lettuce: Effects on phytochemical contents, biochemical profiles and physical properties
  19. 4799
    “…Chronic wounds (e.g. diabetic wounds, pressure wounds, vascular ulcers, etc.) do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events, resulting in a substantial financial burden for patients and society. …”
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    Senescence in chronic wounds and potential targeted therapies
  20. 4800
    “…Multi-UTR genes are widely transcribed and express their alternative 3′UTR isoforms in a cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we investigated if they also regulate 3′UTR isoform expression. …”
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    Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms
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