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  1. 4861
    Publicado 1985
    “…These observations suggest that a subset of kidney cells use an anion transport mechanism analogous to that of erythrocytes and that band 3 is expressed in a noncoordinate manner with other components of the erythroid membrane skeleton in nonerythroid cells.…”
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    Anion transporter: highly cell-type-specific expression of distinct polypeptides and transcripts in erythroid and nonerythroid cells
  2. 4862
    Publicado 1986
    “…The C- kinase inhibitors chlorpromazine and trifluoperazine inhibit the phorbol diester stimulated phosphorylation of site T3 in a dose- dependent manner. These agents inhibit the phosphorylation of T3 in response to NGF, but have no effect on NGF's ability to cause T1 phosphorylation. …”
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    Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases
  3. 4863
    Publicado 1996
    “…Within the resolution of these immunodetection techniques, we show that proteins encoded by the SIR3, SIR4, and RAP1 genes colocalize in a statistically significant manner with Y' telomere- associated DNA sequences. …”
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    The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
  4. 4864
    por Chesney, Alan M., Kemp, Jarold E.
    Publicado 1924
    “…Untreated syphilitic rabbits are also refractory toward a second inoculation made in a similar manner and at a similar interval following the first inoculation. 4. …”
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    EXPERIMENTAL OBSERVATIONS ON THE "CURE" OF SYPHILIS IN THE RABBIT WITH ARSPHENAMINE
  5. 4865
    “…Previously, we have shown that melanosomes of Xenopus laevis melanophores are transported along both microtubules and actin filaments in a coordinated manner, and that myosin V is bound to purified melanosomes (Rogers, S., and V.I. …”
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    Regulation of Melanosome Movement in the Cell Cycle by Reversible Association with Myosin V
  6. 4866
    “…These results identify the TRAP complex as a functional component of the translocon and demonstrate that it acts in a substrate-specific manner to facilitate the initiation of protein translocation.…”
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    Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane
  7. 4867
    por Nelson, MT
    Publicado 1986
    “…However, when added to a solution that contained another type of permeant divalent cation, manganese reduced the single channel current in a voltage-dependent manner. Cadmium, a potent blocker of macroscopic "ensemble" calcium currents in many preparations, reduced the current through an open channel in a manner consistent with Cd ions both not being measurably permeant and interacting with a single site. …”
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    Interactions of divalent cations with single calcium channels from rat brain synaptosomes
  8. 4868
    “…In addition, all other brain vessels were displayed in a manner similar to their appearance on CT angiograms. …”
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    Angiographic CT with intravenous administration of contrast medium is a noninvasive option for follow-up after intracranial stenting
  9. 4869
    “…Here we test the hypothesis that the number of tissues in which a gene is expressed is related in a significant manner to the extent of promoter sequence conservation. …”
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    Housekeeping genes tend to show reduced upstream sequence conservation
  10. 4870
    “…Based on nearest neighbor analysis, the addition of a single 3′ dangling nucleotide increases the stability of duplex formation up to 1 kcal/mol in a sequence-dependent manner. The addition of a second dangling nucleotide increases the stability of duplexes closed with wobble base pairs in an idiosyncratic manner. …”
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    Thermodynamic analysis of 5′ and 3′ single- and 3′ double-nucleotide overhangs neighboring wobble terminal base pairs
  11. 4871
    por Kim, Wan Kyu, Marcotte, Edward M.
    Publicado 2008
    “…Here, we show that the interaction density and homodimeric frequency are highly protein age–dependent in real PPI networks in a manner which does not agree with these canonical models. …”
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    Age-Dependent Evolution of the Yeast Protein Interaction Network Suggests a Limited Role of Gene Duplication and Divergence
  12. 4872
    “…P. yoelii- infected erythrocytes inhibit the maturation of DCs in vitro in a dose-dependent manner, which is consistent with the inhibition found during late infection when parasite burden is highest. …”
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    A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells
  13. 4873
    “…Within their rather broad expression domains, individual Hox proteins control cell diversification and pattern formation and consequently target gene expression in a highly localized manner, sometimes even only in a single cell. To achieve this high-regulatory specificity, it has been postulated that Hox proteins co-operate with other transcription factors to activate or repress their target genes in a highly context-specific manner in vivo. …”
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    Multifactorial Regulation of a Hox Target Gene
  14. 4874
    “…Area under the curves of plasma glucose and insulin concentrations was reduced by barley intake in a dose-dependent manner. Although plasma desacyl ghrelin levels decreased postprandially, the degree of reduction was suppressed by barley intake in a dose-dependent manner. …”
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    Dose-Dependent Effects of Barley Cooked with White Rice on Postprandial Glucose and Desacyl Ghrelin Levels
  15. 4875
    “…Hp perturbs the polarized epithelium in a highly localized manner, since wild-type Hp does not rescue the growth defect of the CagA-deficient mutants upon co-infection. …”
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    Helicobacter pylori Usurps Cell Polarity to Turn the Cell Surface into a Replicative Niche
  16. 4876
    “…A significant increase of IL-6, IL-12, IFN-γ and TNF-α was observed in the HI group after treatment with FR-91. In a similar manner an increase of IL-2, IL-6, IL-12, IFN-γ and TNF-α was also observed in the NHL group. …”
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    Effects of FR-91 on Immune Cells from Healthy Individuals and from Patients with Non-Hodgkin Lymphoma
  17. 4877
    “…In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose limitation extends replicative lifespan in a manner that depends on Sir2 and the NAD(+ )salvage enzymes, nicotinic acid phosphoribosyl transferase and nicotinamidase. …”
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    NAD(+ )metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
  18. 4878
    por Kithas, Philip A, Supiano, Mark A
    Publicado 2010
    “…Starting at low doses and proceeding in a gradual manner, these agents have proven efficacy in decreasing the risk of stroke and cardiovascular events. …”
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    Practical recommendations for treatment of hypertension in older patients
  19. 4879
    “…Engineering tumor cells in a rapid and effective manner to simultaneously display on their surface a collection of immunostimulatory proteins with additive/synergistic functions presents a novel alternative approach to gene therapy with considerable potential for cancer immunotherapy.…”
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    Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy
  20. 4880
    “…It also inhibited cell proliferation in dose- and time-dependent manner as measured by 3-[4,5-methylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assay at 24 and 48 h. …”
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    Anticancer property of gallic acid in A549, a human lung adenocarcinoma cell line, and possible mechanisms
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