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  1. 4941
    por Moon, W, Wettlaufer, J S
    Publicado 2014
    “…The problem with the scheme is that the area evolution is handled in a manner that violates the basic rules of calculus, which leads to a neglected area evolution term that is equivalent to neglecting a leading-order latent heat flux. …”
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    On the nature of the sea ice albedo feedback in simple models
  2. 4942
    “…Sinulariolide inhibited the migration and invasion effects of hepatocellular carcinoma cells in a concentration-dependent manner. The results of zymography assay showed that sinulariolide suppressed the activities of matrix metalloproteinase (MMP)-2 and MMP-9. …”
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    Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways
  3. 4943
    “…Although both pasteurized and formula milk are pathogen free and prepared in a quality controlled manner, the effect they have on the virulence of Campylobacter species is unknown. …”
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    Milk Modulates Campylobacter Invasion into Caco-2 Intestinal Epithelial Cells
  4. 4944
    “…MSU crystals significantly decreased the viability of primary chondrocytes in a time- and dose-dependent manner. DNA fragmentation was observed in a culture medium of MSU crystal-treated chondrocytes, but not in cell lysates. …”
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    Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process
  5. 4945
    “…According to the model of spatial learning proposed by Miller and Shettleworth (2007, 2008), geometric cues compete for associative strength in the same manner as non-geometric cues do. The experiments reported here were designed to test if humans learn about local geometric cues in a manner consistent with the Miller-Shettleworth model. …”
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    Blocking Spatial Navigation Across Environments That Have a Different Shape
  6. 4946
    “…We argue that listeners navigate the variability in referential resolution by calibrating their expectations for the amount of linguistic signal to be expended for a certain meaning and by doing so in a context- or a talker-specific manner. Focusing on talker-specificity, we present four experiments. …”
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    Talker-Specific Generalization of Pragmatic Inferences based on Under- and Over-Informative Prenominal Adjective Use
  7. 4947
    “…Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation. …”
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    The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
  8. 4948
    “…Tral 1 was shown to inactivate GSTε2 both in a time-dependent manner and in a concentration-dependent manner. The half-life of GSTε2 in the presence of 25 μM ethacrynic acid (ETA) was 22 minutes and with Tral 1 was 30 minutes, indicating that Tral 1 was not as efficient as ETA as an inactivator. …”
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    Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin
  9. 4949
    “…When studied on yeast induced pyrexia, methanol and petroleum ether fractions significantly lowered the rectal temperature time dependently in a manner similar to standard drug paracetamol and distinctly more significant (P < 0.001) after second hour. …”
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    Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus
  10. 4950
    “…The positive effects of amino acids can be reproduced by modulating the medium pH, indicating that amino acids contribute to chronological longevity in a cell-extrinsic manner by alleviating medium acidification. In addition, we showed that the amino acid-mediated effects on extension of chronological longevity are independent of those achieved through a reduction in the TORC1 pathway, which is mediated in a cell-intrinsic manner. …”
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    Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae
  11. 4951
    por Katakai, Tomoya, Kinashi, Tatsuo
    Publicado 2016
    “…We propose that T cells dynamically switch between two motility modes; anchorage-dependent and -independent manners. Unique tissue microenvironment and characteristic migration modality of T cells cooperatively generate high-speed interstitial movement in the LN.…”
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    Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node
  12. 4952
    “…In this review, we discuss a clear disconnect between the pathobiology of tumour hypoxia, the pharmacology of hypoxia-activated prodrugs and the manner in which they have been taken into clinical development. …”
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    Hypoxia-activated prodrugs: paths forward in the era of personalised medicine
  13. 4953
    por Wang, Moye, Hu, Jie, Zhang, Zhuqing
    Publicado 2016
    “…The complicated folding manner of DS119 implies the important influence of natural selection on protein-folding kinetics, and more improvement should be achieved in rational protein design.…”
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    The Folding of de Novo Designed Protein DS119 via Molecular Dynamics Simulations
  14. 4954
    por Shi, Haohong, Luo, Xingjing
    Publicado 2016
    “…RESULTS: THF promoted neurite outgrowth of DRG neurons in dose-dependent manner, with an EC(50) concentration of 67.4 nM. Western blot analysis showed THF activated TrkB signaling pathway by inducing TrkB phosphorylation. …”
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    7, 8, 3′-Trihydroxyflavone Promotes Neurite Outgrowth and Protects Against Bupivacaine-Induced Neurotoxicity in Mouse Dorsal Root Ganglion Neurons
  15. 4955
    “…Results: We found that LG268 inhibited the proliferation of NB4 cells in a dose-dependent manner. Flow cytometry analysis showed that LG268 accelerated apoptosis in NB4 cells in a time- dependent manner and that LG268 treatment led to cell cycle arrest at G0/G1 phase. …”
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    Effects of LG268 on Cell Proliferation and Apoptosis of NB4 Cells
  16. 4956
    “…Visual textures have played a key role in image understanding because they convey important semantics of images, and because texture representations that pool local image descriptors in an orderless manner have had a tremendous impact in diverse applications. …”
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    Deep Filter Banks for Texture Recognition, Description, and Segmentation
  17. 4957
    “…Their inhibitory effect was increased in a time and dose-dependent manner, especially in MCF7 cells. However, further studies are needed to reveal the mechanisms of P. abrotanoides extract-induced cell death.…”
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    Ctotoxic and apoptogenic effects of Perovskia abrotanoides flower extract on MCF-7 and HeLa cell lines
  18. 4958
    “…Here we demonstrate that T315 decreases cell viability of acute myeloid leukemia (AML) cell lines (HL-60 and THP-1) and primary leukemia cells from AML patients in a dose-responsive manner. Normal human bone marrow cells are less sensitive than leukemia cells to T315. …”
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    T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death
  19. 4959
    por Oremus, Mark, Xie, Feng, Gaebel, Kathryn
    Publicado 2016
    “…This is especially important for economic evaluations of new AD medications, which require HRQoL to be assessed in a manner that persons with AD often find difficult to undertake. …”
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    Development of Clinical Vignettes to Describe Alzheimer's Disease Health States: A Qualitative Study
  20. 4960
    “…To reverse all these phosphorylations, phosphatases act during mitotic exit in a timely and spatially controlled manner directing the events that lead to a functional G1 nucleus. …”
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    Resetting a functional G1 nucleus after mitosis
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