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  1. 4981
    “…The antibacterial effect of G and GO were in a dose-dependent manner in vitro. The GO or G concentration between 50 and 100 μg/ml may be the better range to keep the balance of cytotoxicity and antibacterial ability. …”
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    Biosafety and Antibacterial Ability of Graphene and Graphene Oxide In Vitro and In Vivo
  2. 4982
    “…These observations demonstrate that there are ageing-related genetic elements that differentially affect mortality in cancer patients in an age-dependent manner. Understanding the genetic determinants affecting prognosis differently with age will be invaluable to develop age-specific prognostic biomarkers and personalized therapies that may improve clinical outcomes for older individuals.…”
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    Identification of polymorphisms in cancer patients that differentially affect survival with age
  3. 4983
    “…The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD(+)-dependent manner and is implicated in cellular senescence and aging. …”
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    SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
  4. 4984
    “…We find that dynein can be in biochemically and functionally distinct pools: either tracking dynamic microtubule plus‐ends in an EB‐dependent manner or moving processively towards minus ends in an adaptor protein‐dependent manner. …”
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    Combinatorial regulation of the balance between dynein microtubule end accumulation and initiation of directed motility
  5. 4985
    “…In this study, we showed that trehalose not only promoted autophagy, but also increased p62 protein expression, in an autophagy-independent manner. In addition, trehalose increased nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in a p62-dependent manner and enhance expression of its downstream antioxidant factors, heme oxygenase-1 (Ho-1) and nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (Nqo1). …”
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    Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways
  6. 4986
    “…Oxidations occur in a predictable manner, with outstanding levels of product chemoselectivity, preserving the first-formed hydroxylation product, thus representing an extremely valuable tool for synthetic planning and development.…”
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    Chemoselective Aliphatic C–H Bond Oxidation Enabled by Polarity Reversal
  7. 4987
    por Gutmann, James L.
    Publicado 2017
    “…However, this was not always the case, as the nature of tooth resorption, as is known today, was not really addressed in a significant manner until the mid-1970s. In fact, when first identified as a problem in the early 1800s, the term resorption did not even exist and the process was poorly understood. …”
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    Some historical musings on tooth/root resorption
  8. 4988
    por An, Heeseon, Harper, J. Wade
    Publicado 2017
    “…Moreover, nitrogen starvation in yeast has been reported to promote selective ribosome delivery to the vacuole in an autophagy conjugation system-dependent manner, a process called “ribophagy”(6,7). However, whether ribophagy in mammals is selective or regulated is unclear. …”
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    Systematic Analysis of Ribophagy in Human Cells Reveals By-stander Flux During Selective Autophagy
  9. 4989
    “…Genes or alleles can interact by small RNAs in a homology dependent manner meaning that short interfering (siRNAs) can act in trans at the chromatin level producing stable and heritable silencing phenotypes. …”
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    Environmental Temperature Controls Accumulation of Transacting siRNAs Involved in Heterochromatin Formation
  10. 4990
    “…In contrast, p21 and p27 proteins were induced in a dose‐dependent manner in both situations. This study showed that PPAR‐γ ligands were able to induce growth suppression in anaplastic thyroid cancer cells via a p53‐independent, but p21‐ and p27‐dependent cytostatic pathway. …”
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    Peroxisome Proliferator‐activated Receptor Gamma Activation Induces Cell Cycle Arrest via the p53‐independent Pathway in Human Anaplastic Thyroid Cancer Cells
  11. 4991
    “…JH at 20 kg responded in a manner reflecting the expected fatigue response more so than JH at 0 kg and 11 kg. …”
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    Maximum Strength, Rate of Force Development, Jump Height, and Peak Power Alterations in Weightlifters across Five Months of Training
  12. 4992
    “…In a mixture of TBBPA and TCDD, TBBPA inhibited TCDD suppression of adipocyte and osteoblast differentiation in a dose-dependent manner. Interestingly, we observed lipid droplets in TBBPA-treated cells differentiated into osteoblasts. …”
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    Complex toxicity as disruption of adipocyte or osteoblast differentiation in human mesenchymal stem cells under the mixed condition of TBBPA and TCDD
  13. 4993
    “…The results can enable healthcare professionals to monitor patients and place particular emphasis on those who do not attend their scheduled appointments in a timely manner.…”
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    Analysis of the Relationship between the Referral and Evolution of Patients with Type 2 Diabetes Mellitus
  14. 4994
    “…These results indicated that Rg1 works both in an anti-adipogenic and anti-obesity manner through inducing AMPK activation, inhibiting lipogenesis, and decreasing intracellular lipid content, adipocyte size, and adipose weight.…”
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    Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK
  15. 4995
    “…Methods To determine whether surgeons performed a laparoscopic cholecystectomy in a standardized manner, the study assessed the variability in the frequency of an LN excision. …”
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    Inter-surgeon Variability in Cystic Artery Lymph Node Excision during Laparoscopic Cholecystectomy
  16. 4996
    “…Feedstock pretreatment in a simple, cost effective, agnostic manner is a major challenge. Methods: In this work, beechwood sawdust was delignified via an organosolv process, assisted by homogeneous inorganic acid catalysis. …”
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    Acid Assisted Organosolv Delignification of Beechwood and Pulp Conversion towards High Concentrated Cellulosic Ethanol via High Gravity Enzymatic Hydrolysis and Fermentation
  17. 4997
    por Chen, Chung-Yi, Li, Yi-Wen, Kuo, Soong-Yu
    Publicado 2009
    “…It was found that this compound caused a slow and sustained rise of [Ca(2+)](i) in a concentration-dependent manner. [10]-Gingerol also induced a [Ca(2+)](i) rise when extracellular Ca(2+) was removed, but the magnitude was reduced by 38%. …”
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    Effect of [10]-Gingerol on [Ca(2+)](i) and Cell Death in Human Colorectal Cancer Cells
  18. 4998
    “…GPX inhibited the growth of H520 cells in dose- and time-dependent manners, with IC(50) values of 3.03 ± 0.21 μM at 48 h. …”
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    Griffipavixanthone from Garcinia oblongifolia Champ Induces Cell Apoptosis in Human Non-Small-Cell Lung Cancer H520 Cells in Vitro
  19. 4999
    “…The MTT assay showed that triptolide decreased cell viability in a dose- and time-dependent manner. The results of the colony formation assay indicated that triptolide strongly suppressed colony formation ability in GBC-SD and SGC-996 cells. …”
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    Triptolide Induces S Phase Arrest and Apoptosis in Gallbladder Cancer Cells
  20. 5000
    “…[Image: see text] An aptamer reagent that can switch its binding affinity in a pH-responsive manner would be highly valuable for many biomedical applications including imaging and drug delivery. …”
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    Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity
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