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  1. 5041
    “…Combining metformin (0, 100, 1000 µM) and 10 µM MPA induced significantly decreased cell viability in a time- and dose-dependent manner in Ishikawa cells, but not in KLE and USPC cells. …”
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    Medroxyprogesterone Reverses Tolerable Dose Metformin-Induced Inhibition of Invasion via Matrix Metallopeptidase-9 and Transforming Growth Factor-β1 in KLE Endometrial Cancer Cells
  2. 5042
    “…AGEs in the in vitro iBRB model constructed by RMEC and RMGC co-culture led to the imbalance of the vascular endothelial growth factor (VEGF) and pigment epithelial derivative factor (PEDF), and the permeability of the RMEC layer increased because the TEER decreased in a dose- and time-dependent manner. AGEs increased VEGF but lowered PEDF in a dose- and time-dependent manner. …”
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    Influences of advanced glycosylation end products on the inner blood–retinal barrier in a co-culture cell model in vitro
  3. 5043
    “…Cyp1a1 mRNA levels are induced after irradiation in a dose-dependent manner, and CYP1A1 protein expression increased in the irradiated intestinal tract as well. …”
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    β-Naphthoflavone Activation of the Ah Receptor Alleviates Irradiation-Induced Intestinal Injury in Mice
  4. 5044
    “…The results indicated that 1 inhibited α-glucosidase in a noncompetitive manner, whereas 2 acted in a competitive manner. In molecular docking, the stability of binding was enhanced by π-π T-shaped, π-alkyl, π-π stacked, hydrogen bond, and electrostatic interactions. …”
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    Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel
  5. 5045
    “…It is essential to develop an automated method for reviewing frontal chest X-ray images to alert emergency physicians in a timely manner about the life-threatening condition of hollow organ perforation that mandates an immediate second look. …”
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    A Deep Learning Method for Alerting Emergency Physicians about the Presence of Subphrenic Free Air on Chest Radiographs
  6. 5046
    “…To avoid excessive damage due to the persistence of a highly reactive environment, inflammations need to resolve in a coordinate and timely manner, ensuring for the immunological normalization of the affected tissues. …”
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    Role of Tristetraprolin in the Resolution of Inflammation
  7. 5047
    “…This offers the potential to build a standardized scale useful to profile pain levels in a personalized manner across the general population.…”
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    Personalized Biometrics of Physical Pain Agree with Psychophysics by Participants with Sensory over Responsivity
  8. 5048
    “…SUMOylation and the associated increase of IDOL protein are effectively reversed by SUMO-specific peptidase 1 (SENP1) in an activity-dependent manner. We further demonstrate that SENP1 affects LDLR protein levels by modulating IDOL. …”
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    SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1
  9. 5049
    “…Furthermore, Src family kinases and Ras were found to be recruited to membrane lipid rafts in an LY6D-dependent manner, and inhibition of their activity impaired the LY6D-induced macropinocytosis. …”
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    LY6D-induced macropinocytosis as a survival mechanism of senescent cells
  10. 5050
    “…In the 1-h exposure group, the motor neurons exposed to lidocaine and bupivacaine had reduced cell viability and increased cytotoxicity, ROS, and apoptosis in a concentration-dependent manner. Lidocaine showed the highest toxicity, followed by bupivacaine. …”
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    Neurotoxic Effects of Local Anesthetics on Developing Motor Neurons in a Rat Model
  11. 5051
    “…According to the mixing manner applied, fresh geomortar indicated a marked reduction in workability, increasing the CBF loading. …”
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    Investigation on Flexural Behavior of Geopolymer-Based Carbon Textile/Basalt Fiber Hybrid Composite
  12. 5052
    “…The expression of CycE-Luc and CycE-Luc2 fusion protein was regulated in a cell cycle-dependent manner, which was mediated by proteasome ubiquitination and degradation. …”
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    The G1 phase optical reporter serves as a sensor of CDK4/6 inhibition in vivo
  13. 5053
    “…Ayurveda scholars have mentioned that the manner of tissue nutrition is not same in all phases of life. …”
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    Explication on tissue nutrition in prenatal and postnatal life: An Ayurveda perspective
  14. 5054
    “…The NVJ serves as a metabolic platform by selectively retaining HMG-CoA Reductases (HMGCRs), driving mevalonate pathway flux in an Upc2-dependent manner. Both spatial retention of HMGCRs and increased mevalonate pathway flux during AGR is dependent on NVJ tether Nvj1. …”
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    Glucose restriction drives spatial reorganization of mevalonate metabolism
  15. 5055
    “…A distal release stent system was then inserted in a retrograde manner via the gastrostomy stoma, effectively making it a proximal release stent which enabled more precise positioning of the stent above the tumor. …”
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    Retrograde Radiological Gastrostomy Technique and Retrograde Stent Placement in a Completely Occluded Cervical Esophagus
  16. 5056
    “…It is characterized by thrombocytopenia and anti-PF4 antibodies binding to platelets in AZD1222-dependent manner. Initial clinical experience suggests a risk of unusual and severe thromboembolic events.…”
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    Prothrombotic immune thrombocytopenia after COVID-19 vaccination
  17. 5057
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    Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
  18. 5058
    “…Together, these results show that TRPM4 plays a significant role in the excitability of mPFC layer 2/3 pyramidal neurons by modulating neuronal excitability in a calcium-dependent manner.…”
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    I(CAN) (TRPM4) Contributes to the Intrinsic Excitability of Prefrontal Cortex Layer 2/3 Pyramidal Neurons
  19. 5059
    “…Furthermore, thymol treatment reduced endogenous ergosterol content by decreasing the expression of ergosterol biosynthesis genes in a HOG MAPK pathway-dependent manner. Collectively, this study sheds light on the antifungal mechanisms of thymol against C. neoformans.…”
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    Investigation of Antifungal Mechanisms of Thymol in the Human Fungal Pathogen, Cryptococcus neoformans
  20. 5060
    “…These word assemblies ignite early on in parallel and only later on reverberate in a behavior-specific manner.…”
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    The Same Ultra-Rapid Parallel Brain Dynamics Underpin the Production and Perception of Speech
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