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  1. 5061
    “…We demonstrate that the ZF mutation in EIF-3.G alters translation in a 5′UTR-dependent manner. Our study reveals an in vivo mechanism for eIF3 in governing neuronal protein levels to control neuronal activity states and offers insights into how eIF3 dysregulation contributes to neurological disorders.…”
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    Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity
  2. 5062
    “…AGE 232 showed a significant reduction in death or paralysis in mice caused by collagen/epinephrine-induced thromboembolism in a dose-dependent manner and inhibition of collagen-induced human platelet aggregation in a concentration-dependent manner. …”
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    Antithrombotic Effect of the Ethanol Extract of Angelica gigas Nakai (AGE 232)
  3. 5063
    “…In addition, researchers encode scattered user posts in a sequential or hierarchical manner, ignoring the connection between posts and the unequal value of different posts to classification tasks. …”
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    Personality Classification of Social Users Based on Feature Fusion
  4. 5064
    “…Wnt/β-catenin stimulation instructed the neuronal differentiation of proliferating NSCs and promoted the activation or differentiation of quiescent NSCs in a dose-dependent manner. However, deletion of β-catenin in NSCs did not affect either their activation or maintenance of their stem cell characteristics. …”
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    Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation
  5. 5065
    “…We demonstrate in this work that nanolipoprotein particles (NLPs) synthesized in a cell-free manner can be used to transfer Her2 protein into the membrane of nonmalignant cells in 3D culture in a nontoxic and facile manner. …”
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    Nanolipoprotein-Mediated Her2 Protein Transfection Induces Malignant Transformation in Human Breast Acinar Cultures
  6. 5066
    “…All materials tested show an anisotropic shape-change reaction in a pre-programmed manner, complying with the behavior engineered into the matter. …”
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    Mono–Material 4D Printing of Digital Shape–Memory Components
  7. 5067
    “…Further, we found that foxo OE stimulates in an Nrf2/cncC dependent-manner, counteracting proteostatic pathways, e.g., the ubiquitin-proteasome pathway, which is central in ameliorating the aberrant foxo OE-mediated toxicity. …”
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    Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways
  8. 5068
    “…The prepared proniosome delivered the FN significantly (p < 0.05), compared to the naked finasteride solution in a dose- and time-dependent manner. The FLP treatment significantly increases the number and size of hair follicles in a dose-dependent manner. …”
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    Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice
  9. 5069
    “…Thermal cameras capture the infrared radiation emitted from a body in a contactless manner and can provide an indirect estimation of the autonomic nervous system (ANS) dynamics through the regulation of the skin temperature. …”
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    Towards a Contactless Stress Classification Using Thermal Imaging
  10. 5070
    “…Finally, administration of tamoxifen (20, 50, 100 mg·kg(−1)·d(−1), for 21 days) inhibited the growth of pituitary adenomas xenografts in nude mice in a dose-dependent manner. Taken together, tamoxifen is likely to be a promising combination therapy for pituitary adenomas and should be investigated further.…”
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    Tamoxifen Exerts Anticancer Effects on Pituitary Adenoma Progression via Inducing Cell Apoptosis and Inhibiting Cell Migration
  11. 5071
    “…Wireless communications, laser and computer technologies have all been achieved by altering the way light and other energy forms act naturally and how to manage them in a controlled manner. At the nanoscale, to control light and heat, matured nanostructure fabrication techniques have been developed in the last two decades, and a wide range of groundbreaking processes have been achieved. …”
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    Metamaterials and Metasurfaces: A Review from the Perspectives of Materials, Mechanisms and Advanced Metadevices
  12. 5072
    “…This measurement in a non-contact, non-invasive, continuous manner through the human skull and scalp in the standard environment is completed through a lightweight inexpensive helmet. …”
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    Measuring Electromagnetic Field Activity Generated by Neurons In Vivo by Humans With Thoughts of Repetitive Motor Activities and Emotional Thoughts
  13. 5073
    “…Genome-wide chromatin immunoprecipitation and target-specific electrophoretic mobility shift assays demonstrate that Sul12a of S. acidocaldarius interacts with DNA in a non-sequence specific manner, while atomic force microscopy imaging of Sul12a–DNA complexes indicate that the protein induces structural effects on the DNA template. …”
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    DNA-Binding Properties of a Novel Crenarchaeal Chromatin-Organizing Protein in Sulfolobus acidocaldarius
  14. 5074
    “…Different kinetic and equilibrium models were used to characterize the biosorption manner of Spirulina as a biosorbent. The kinetic manner of Zn(2+) biosorption was well characterized by the pseudo-second-order, implying that the adsorption process is chemical in nature. …”
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    Kinetic, Isotherm and Thermodynamic Aspects of Zn(2+) Biosorption by Spirulina platensis: Optimization of Process Variables by Response Surface Methodology
  15. 5075
    por Yang, Chun, Chen, Xuqi, Sun, Jie, Gu, Chao
    Publicado 2022
    “…On the one hand, alternative foods produced in an innovative manner serve to energize the consumer market by expanding dietary choices. …”
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    The Impact of Alternative Foods on Consumers’ Continuance Intention from an Innovation Perspective
  16. 5076
    “…DCNN trained in an end-to-end manner achieved the highest accuracy of 99.19% on the testing set, which was finally employed to visualize the variety classification. …”
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    Variety identification of oat seeds using hyperspectral imaging: investigating the representation ability of deep convolutional neural network
  17. 5077
    “…DTB significantly inhibited colon cancer cell proliferation, migration, and apoptosis in a dose-dependent manner without significant effects on normal colonic epithelial cells NCM460. …”
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    Inhibitory Effects and Mechanism of the Natural Compound Diaporthein B Extracted from Marine-Derived Fungi on Colon Cancer Cells
  18. 5078
    “…These tasks require moving a wire loop along an arbitrarily shaped wire obstacle in a collision-free manner. While there have been some demonstrations of buzzwire tasks with robotic manipulators using reinforcement learning and admittance control, there does not seem to be any examples with humanoid robots. …”
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    Optimization-Based Motion Generation for Buzzwire Tasks With the REEM-C Humanoid Robot
  19. 5079
    “…In quiescence, yeast proteasomes are sequestered in an ubiquitin-dependent manner into motile and reversible proteasome storage granules in the cytoplasm. …”
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    Intracellular localization of the proteasome in response to stress conditions
  20. 5080
    “…The study illustrated that debelalactone (DL) significantly downregulated the hepatic, non-hepatic parameters such as aspartate aminotransferase, alanine aminotransferase, alpha fetoprotein, NO levels, total protein, albumin, blood urea nitrogen, total bilirubin, and direct bilirubin in dose dependent manner, as well as noticeably improving the body weight, of treated animals. …”
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    Debelalactone Prevents Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress on Male Wistar Rats
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