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  1. 5161
    “…Generation of prostaglandin-E2 (PGE2) in a cyclo-oxygenase-2 (COX-2)-dependent manner in the macula densa, the salt-sensing cells of the kidney, plays a dominant role in renin regulation. …”
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    MicroRNA-132 regulates salt-dependent steady-state renin levels in mice
  2. 5162
    “…Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of β-catenin in a largely PYGO-independent manner. Our genetic analyses implied that BCL9 necessitates other interaction partners in mediating its transcriptional output. …”
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    TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex
  3. 5163
    “…To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired. …”
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    Tissue-targeted R-spondin mimetics for liver regeneration
  4. 5164
    “…In a genotype-dependent manner, the phenotypic impact of patient-specific NRXN1(+/−) mutations can occur through a reduction in wild-type NRXN1α isoform levels as well as the presence of mutant NRXN1α isoforms.…”
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    Neuronal impact of patient-specific aberrant NRXN1α splicing
  5. 5165
    “…However, when opsonized with sCL-12, properdin bound in a C3-independent manner exclusively via its tetrameric structure and directed in situ C3bBb assembly. …”
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    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
  6. 5166
    “…Furthermore, DMA treated animals showed complete infertility in a dose dependent manner, as no pups were born despite proper mating between females and DMA treated males. …”
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    Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats
  7. 5167
    “…Endothelial cell proliferation, angiogenic gene expression and phosphorylation of AKT and ERK are enhanced in a dose dependent manner until 0.15 mJ/mm(2) energy flux density. SWT induces regeneration of ischemic muscle in vivo via expression of angiogenic gene expression, enhanced neovascularization and improved limb perfusion in a dose-dependent manner. …”
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    Defining a therapeutic range for regeneration of ischemic myocardium via shock waves
  8. 5168
    “…The lactone form of VC binds to the active site and mono-coordinates the Fe(2+) in a manner different from 2-OG. The dsDNA binds to a positively charged cleft of CMD1 and the 5mC/C is inserted into the active site and recognized by CMD1 in a similar manner as the TET proteins. …”
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    Molecular mechanism for vitamin C-derived C(5)-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1
  9. 5169
    “…Physiological systems vary in a day-night manner anticipating increased demand at a particular time. …”
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    RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
  10. 5170
    “…The Ku homodimer alone forms a ∼2 s synapsis between blunt DNA ends that is increased to ∼18 s upon addition of LigD, in a manner dependent on the C-terminal arms of Ku. The synapsis lifetime increases drastically for 4 nt complementary DNA overhangs, independently of the C-terminal arms of Ku. …”
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    Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
  11. 5171
    “…We show that PLK1 is enriched at double strand breaks (DSBs) within seconds of UV laser irradiation in a PARP-1-dependent manner and then disperses within 10 min in a PARG-dependent manner. …”
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    PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
  12. 5172
    “…In the most basal epithelial cells, secreted APRIL accumulated inside secretory lamp-1(+) vesicles in a polarized manner, facing the sub-epithelium. The tonsil epithelium upregulated APRIL production by apical cells and secretion by basal cells upon Toll-like receptor stimulation. …”
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    Polarized Secretion of APRIL by the Tonsil Epithelium Upon Toll-Like Receptor Stimulation
  13. 5173
    “…These nanoparticles participate in cell-to-cell communication in a paracrine manner. It is thought that the application of Exo can circumvent several drawbacks related to whole-cell therapies. …”
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    Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine
  14. 5174
    “…This study reveals a new role for a placental hormone in shaping brain regions and behaviors in a sex-linked manner. Placental hormone replacement might offer novel therapeutic opportunities to prevent later neurobehavioral disorders.…”
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    Placental endocrine function shapes cerebellar development and social behavior
  15. 5175
    “…CONCLUSION: A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.…”
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    Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
  16. 5176
    “…Consistent with this, cytokinin application rescues nodulation and nitrogen fixation of biosynthesis mutants in a concentration dependent manner. These inhibitory impacts of nitrate on symbiosis occur in a Nlp1 and Nlp4 dependent manner and contrast with the positive influence of nitrate on cytokinin biosynthesis that occurs in species that do not form symbiotic root nodules. …”
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    Nitrate restricts nodule organogenesis through inhibition of cytokinin biosynthesis in Lotus japonicus
  17. 5177
    “…Our results indicate that HoxB8-conditional progenitors engraft in a β1 integrin-dependent manner and transiently generate donor-derived mature neutrophils. …”
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    Engraftment, Fate, and Function of HoxB8-Conditional Neutrophil Progenitors in the Unconditioned Murine Host
  18. 5178
    “…We report here on regulatory pre-mRNA structures that could function as regulators by controlling the use of splice sites in a temperature-dependent manner. We investigate pre-mRNA structures at the splice sites of intron 2 of the gene coding for HsfA2 from S. lycopersicum using NMR- and CD-spectroscopy as well as in-line probing. …”
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    Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants
  19. 5179
    “…Regardless of the internalization pathway used, CSPG-bound rVAR2 was trafficked to the early endosomes in an energy-dependent manner but not further transported to the lysosomal compartment. …”
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    Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells
  20. 5180
    “…We also provided an overview of various studies on the influence of key parameters on the in vivo pharmaceutical behavior of NMs that had been visualized in a non-invasive and real-time manner. GRAPHICAL ABSTRACT: [Image: see text]…”
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    Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations
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