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  1. 5221
    por Arce, E, Ehlers, MD
    Publicado 2016
    “…Advances in neurobiology, circuit neuroscience, and clinical assessment technology are converging in a manner that holds promise for the development of new pharmacological agents for cognitive enhancement in neuropsychiatric disease.…”
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    The Mind Bending Quest for Cognitive Enhancers
  2. 5222
    “…Combined with areogel processing and specialized bacteria domestication, each tiny TSM could realize large area pollutant treatment precisely in an impressive half-automatically manner.…”
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    3D printed self-driven thumb-sized motors for in-situ underwater pollutant remediation
  3. 5223
    “…In this paper, we reviewed the atrial fibrillation screening strategies in a stepwise manner and discussed the uncertainties in the assessment of the need for anticoagulation in light of the recently published European Heart Rhythm Association consensus document. …”
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    Lessons from the current European Heart Rhythm Association consensus document on screening for atrial fibrillation
  4. 5224
    “…This scheme leads to reliable identification within 3 days in an economically viable manner when compared to other methods.…”
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    Online Artículo Texto
    A practical molecular identification of nonfermenting Gram-negative bacteria from cystic fibrosis
  5. 5225
    por Chassaing, Benoit, Gewirtz, Andrew T
    Publicado 2018
    “…A critically important new study by leading inflammatory bowel disease (IBD) researcher Fabio Cominelli and colleagues reveals that, in mice, the artificial sweetener SPLENDA deleteriously impacts the intestinal microbiota in a manner that promotes Crohn’s-type disease in genetically susceptible hosts. …”
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    Not so Splendid for the Gut Microbiota
  6. 5226
    “…Five different halofunctionalizations of acyclic monoterpenoids were performed using a combination of a hypervalent iodine(III) reagent and a halide salt. In this manner, the dibromination, the bromo(trifluoro)acetoxylation, the bromohydroxylation, the iodo(trifluoro)acetoxylation or the ene-type chlorination of the distal trisubstituted double bond occurred with excellent selectivity and moderate to good yields.…”
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    Online Artículo Texto
    Iodine(III)-mediated halogenations of acyclic monoterpenoids
  7. 5227
    “…Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er).…”
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    Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins
  8. 5228
    “…Nevertheless, when hostile anatomy prevents successful percutaneous coronary interventions (PCI) from the radial access, transfemoral use of sheathless guide can assist in overcoming these challenges in a safe manner.…”
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    Sheathless guiding catheter from a femoral approach for complex percutaneous coronary interventions —An unusual solution for an often‐encountered problem
  9. 5229
    “…2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K(i) of 4.2±0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.…”
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    Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
  10. 5230
    por Han, Chuanhui, Fu, Yang-Xin
    Publicado 2020
    “…(https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model.…”
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    β-Catenin regulates tumor-derived PD-L1
  11. 5231
    por Wachten, Dagmar, Mill, Pleasantine
    Publicado 2023
    “…For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmetric gene expression.…”
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    Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
  12. 5232
    “…The distribution of each pathogen and the accompanying histopathology suggested the infections progressed in a mutually exclusive manner within the lung, resulting in fatal respiratory failure.…”
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    Lung Pathology of Mutually Exclusive Co-infection with SARS-CoV-2 and Streptococcus pneumoniae
  13. 5233
    por Weinzierl, David, Waser, Mario
    Publicado 2021
    “…This protocol allows for a reasonable synthetically useful s-factor of 20 and provides a novel entry to obtain this interesting planar chiral motive in an enantioenriched manner.…”
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    Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane
  14. 5234
    “…In this paper, it is argued that (i) PCA is an excellent technique to describe continuous flexibility at low resolution (but not so much at high resolution) and (ii) PCA components should be analyzed in a concerted manner (and not independently).…”
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    Principal component analysis is limited to low-resolution analysis in cryoEM
  15. 5235
    “…A novel frameshift variant was identified in APOB that segregates in a dominant manner with low levels of low-density lipoprotein cholesterol. …”
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    A Novel Variant in APOB Gene Causes Extremely Low LDL-C Without Known Adverse Effects
  16. 5236
    por Hamal, Pawan Kumar
    Publicado 2021
    “…The South Asian Editors of this book, have made a tremendous painstaking effort to consider these issues and present the content as per the need of the local scenarios in an evidence-based manner.…”
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    Clinical Anesthesia, South Asian Edition: A Book Review
  17. 5237
    “…Isthmin-1 is a secreted protein with multiple capability; however, it truly attracts our attention since the definition as an adipokine in 2021, which exerts indispensable roles in various pathophysiological processes through the endocrine or autocrine manners. In this review, we summarize recent knowledge of isthmin-1, including its distribution, structure, receptor and potential function.…”
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    A brief overview about the adipokine: Isthmin-1
  18. 5238
    por Fox, Maayan, Gorodetski, Yuri
    Publicado 2023
    “…Accordingly, it is possible to obtain a precise interaction of the incident light signal and a specific plasmonic directional mode in a polarization dependent manner.…”
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    Topologically protected plasmonic phases in randomized aperture gratings
  19. 5239
    “…This work aimed to carry out chemical cooking of corn stalks, both in a nitrate-alkaline manner and in a soda pulp method. The composition of corn is characterized by cellulose, lignin, ash, and substances extractable into polar and organic solvents. …”
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    Chemical pulp from corn stalks()
  20. 5240
    por Trott, Michael
    Publicado 2014
    “…Ensuring that the SM effective field theory (EFT) is constrained correctly when using constructed observables requires that their defining conditions are imposed on the EFT in a manner that is consistent with the equations of motion. …”
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    On the consistent use of Constructed Observables
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