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5241“…The prospects for the measurement of the pseudoscalar admixture in the h-tau-tau coupling to a Standard Model Higgs boson of 120 GeV mass are discussed in a quantitative manner e+ e- collisions of 350 GeV centre-of-mass energy. …”
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5242por Ploeg, Emily Maria, Britsch, Isabel, van Wijngaarden, Anne Paulien, Ke, Xiurong, Hendriks, Mark Alexander Johannes Martinus, Samplonius, Douwe Freerk, Helfrich, Wijnand“…To address this issue, we constructed a novel bispecific antibody (bsAb) CD73xEpCAM that inhibits CD73 expressed on the OC cell surface in an EpCAM-directed manner. Importantly, bsAb CD73xEpCAM showed potent capacity to inhibit the CD73 enzyme activity in an EpCAM-directed manner and restore the cytotoxic activity of ADO-suppressed anticancer T cells. …”
Publicado 2023
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5243por Jariwala, Unnati, Prescott, Jennifer, Jia, Li, Barski, Artem, Pregizer, Steve, Cogan, Jon P, Arasheben, Armin, Tilley, Wayne D, Scher, Howard I, Gerald, William L, Buchanan, Grant, Coetzee, Gerhard A, Frenkel, Baruch“…Another AR target gene, ornithine aminotransferase (OAT), was AR-stimulated in a ligand-independent manner, since it was repressed by AR siRNA knockdown, but not stimulated by DHT. …”
Publicado 2007
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5244por Ohmura, E., Wakai, K., Isozaki, O., Murakami, H., Onoda, N., Emoto, N., Shizume, K., Tsushima, T., Demura, H., Robins, R. K.“…It is concluded that CT and 8-Cl-cAMP inhibit PC cell growth, presumably in a similar manner, and their mechanism(s) of action may be different from that of TPA. …”
Publicado 1993
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5245“…In still another test the Levaditi virus was combined with the neurovaccine in a manner calculated to bring about the maximum action of each at the same time. …”
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5246“…RT-PCR and western blot analysis showed that both CYP1A1 mRNA and protein expression were increased in a dose-dependent manner following TCDD treatment and AhR antagonist resveratrol (RSV) could reverse this TCDD-induced CYP1A1 expression. …”
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5247por Rodríguez-Fragoso, Patricia, Reyes-Esparza, Jorge, León-Buitimea, Angel, Rodríguez-Fragoso, Lourdes“…A reduction in MDA-MB-231 cells was observed with concentrations higher than 4.92 nM in a dose response manner, while Caco-2 cells showed an important increase starting at 1.64 nM. …”
Publicado 2012
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5248por Shah, Syed M., Ravi Kumar, G. V. P. P. S., Brah, G. S., Santra, Lakshman, Pawar, Hitesh“…We observed the induction of TLR2 expression in a dose- and time-dependent manner and the peptidoglycan induced tolerance beyond 30 μg/ml dose at all incubation periods. …”
Publicado 2012
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5249Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axispor Teng, Fei, Tian, Wen-Yan, Wang, Ying-Mei, Zhang, Yan-Fang, Guo, Fei, Zhao, Jing, Gao, Chao, Xue, Feng-Xia“…CAFs promoted EC progression via the SDF-1α/CXCR4 axis to activate the PI3K/Akt and MAPK/Erk signalings in a paracrine-dependent manner or increase MMP-2 and MMP-9 secretion in an autocrine-dependent manner. …”
Publicado 2016
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5250por Xie, Xiang-Zhu, Huang, Xin, Zhao, Shui-Ping, Yu, Bi-Lian, Zhong, Qiao-Qing, Cao, Jian“…CONCLUSIONS: OxLDL induces C/EBPβ protein synthesis in a time-dependent manner and enhances MCP-1 secretion and expression in 3T3-L1 adipocytes. …”
Publicado 2016
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5251por Qian, Yan-Fei, Wang, Yang, Tian, Wei-Wei, Wang, Sheng, Zhao, Lei, Li, Li, Ma, Ke-Tao, Si, Jun-Qiang“…RMF served a diastolic role in the cerebral basilar arteries of rats in a dose-dependent manner, likely by activating the BKCa and Kv channels. …”
Publicado 2017
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5252por Gao, Yuan, Li, Miao, Wang, Yan, Li, Zhengqi, Fan, Chenyu, Wang, Zheng, Cao, Xinyu, Chang, Junbiao, Qiao, Hailing“…BZP (0.75, 3, and 12 mg/kg), however, reduced the expression of Cyt-c, caspase-3, and the Bax/Bcl-2 ratio, in a dose-dependent manner (P < 0.01). There was low expression of p-Akt and PI3K in Model group, compared with the sham group (P < 0.01). …”
Publicado 2017
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5253por Bahman, Abdulmajeed A., Abaza, Mohamed Salah I., Khoushiash, Sarah I., Al-Attiyah, Rajaa J.“…NPCs markedly potentiated the therapeutic efficacy of Sora in a sequence-, type-, NPC dose- and cell line-dependent manner. Concomitant treatment with Sora and Cur [sensitization ratio (SR)=28], Kmf (SR=18) or Que (SR=8) was associated with the highest SRs in Hep3b cells. …”
Publicado 2018
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5254por Grisanti, Laurel A., Thomas, Toby P., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Koch, Walter J., Benovic, Jeffrey L., Tilley, Douglas G.“…Results: Intramyocardial injection of ICL1-9 at the time of I/R reduced infarct size, cardiomyocyte death and improved cardiac function in a β2AR- and βarr-dependent manner, which led to improved contractile function early and less fibrotic remodeling over time. …”
Publicado 2018
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5255“…ER Ca(2+) release via IP(3) receptors modulates NMDA receptor‐dependent plasticity in a graded manner, to selectively promote synaptic depression with relatively diminished effect on LTP induction; this may temper further strengthening at the stronger synapses which are preferentially associated with ER‐containing spines. …”
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5256por Hamdard, Enayatullah, Shi, Zhicheng, Lv, Zengpeng, Zahir, Ahmadullah, Wei, Quanwei, Rahmani, Mohammad Malyar, Shi, Fangxiong“…In conclusion, DB exerts adverse effects on the heart/kidney of chickens in a dose-response manner via damaging the epithelium of the heart/kidney by inducing apoptosis, autophagy associated with bitter taste and effector gene expressions. …”
Publicado 2019
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5257por Ahmed, Nirmen F., Sadek, Kadry M., Soliman, Magdy Kh., Khalil, Reyad H., Khafaga, Asmaa F., Ajarem, Jamaan S., Maodaa, Saleh N., Allam, Ahmed A.“…It is concluded that MO leaves are a promising antioxidant plant via downregulation of lipid peroxidation, and upregulation of antioxidant enzyme activity including SOD, CAT, GPx, GSH, and TAC in liver, kidney, gills, and muscle tissue in a time-dependent manner, in addition to downregulation of mRNA expression of antioxidant-related genes. …”
Publicado 2020
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5258“…Alzheimer’s disease (AD) is a disease characterized by cerebral neuronal degeneration and loss in a progressive manner. Amyloid beta (Aβ) in the brain is toxic to neurons, being a main risk factor for initiation and continuation of cognitive deterioration in AD. …”
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5259“…This process of designing in a participatory manner with the sakis resulted in an interactive system that was shown to be viable, non-invasive, highly interactive, and easy to use in a zoo habitat. …”
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5260por Kuzmich, Sofya, Skotnicka, Dorota, Szadkowski, Dobromir, Klos, Philipp, Pérez‐Burgos, María, Schander, Eugenia, Schumacher, Dominik, Søgaard-Andersen, Lotte“…In contrast, PixA acts in a Frz-independent manner to regulate motility. Taking our results together with previous observations, we conclude that PilZ domain proteins and c-di-GMP act in multiple independent pathways to regulate motility and development in M. xanthus.…”
Publicado 2021
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