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  1. 5381
    “…Acute appendicitis (AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. …”
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    Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy
  2. 5382
    “…In addition, ascites repressed the expression of miRNA-125b in a TGF-β-dependent manner. Mimic of miR-125b blocked ascites-induced cell migration. …”
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    Ascites promotes cell migration through the repression of miR-125b in ovarian cancer
  3. 5383
    “…Opioid stimulation of JNK also inactivates dopamine D2 receptors in a PRDX6-dependent manner. We show that the loss of this lipid modification distorts the receptor G-protein association, thereby preventing agonist-induced guanine nucleotide exchange. …”
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    Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
  4. 5384
    “…We propose a regulatory mechanism of Rab5 where monoubiquitination downregulates effector recruitment and GDP/GTP conversion in a site-specific manner.…”
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    Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion
  5. 5385
    “…Ablation of ERG expression results in endothelial-to-mesenchymal transition (EndMT) and spontaneous liver fibrogenesis in EC-specific constitutive hemi-deficient (Erg(cEC-Het)) and inducible homozygous deficient mice (Erg(iEC-KO)), in a SMAD3-dependent manner. Acute administration of the TNF-α inhibitor etanercept inhibits carbon tetrachloride (CCL(4))-induced fibrogenesis in an ERG-dependent manner in mice. …”
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    Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
  6. 5386
    “…These results constitute the first evidence that the transfer of experience profoundly affects the manner in which hippocampus encodes complex information.…”
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    Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus
  7. 5387
    “…The produced protons are characterized by high-energies (with a broad spectrum), are emitted in a very directional manner, and the process is associated to relaxed laser (no need for high-contrast) and target (no need for ultra-thin or expensive targets) constraints. …”
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    Acceleration of collimated 45 MeV protons by collisionless shocks driven in low-density, large-scale gradient plasmas by a 10(20) W/cm(2), 1 µm laser
  8. 5388
    “…RESULTS: According to MTT assay results, Evo significantly inhibited the cell proliferation in a time- and dose-dependent manner. Fluorescence microscopy and flow cytometry analyses revealed that Evo induced cell apoptosis in a concentration-dependent manner. …”
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    Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
  9. 5389
    “…Kmer-SSR, coupled with the filter options, accurately and intuitively identifies SSRs quickly and in a more user-friendly manner than any other SSR identification algorithm. …”
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    Kmer-SSR: a fast and exhaustive SSR search algorithm
  10. 5390
    “…This critical information has to be captured and encoded in a computable manner, which is currently far beyond the current capabilities of automatically constructed network. …”
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    Expert curation for building network-based dynamical models: a case study on atherosclerotic plaque formation
  11. 5391
    “…A screen for small molecule modulators for aggrephagy identified ERRα inverse agonist XCT 790, that cleared α-synuclein aggregates in an autophagy dependent, but mammalian target of rapamycin (MTOR) independent manner. XCT 790 modulates autophagosome formation in an ERRα dependent manner as validated by siRNA mediated knockdown and over expression approaches. …”
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    Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective
  12. 5392
    “…Therefore, Avp deletion appears to affect microbiota composition in a sexually differentiated manner.…”
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    Vasopressin deletion is associated with sex-specific shifts in the gut microbiome
  13. 5393
    “…The artificial ILM was peeled underwater in the same manner as in an actual operation.…”
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    A surgical simulator for peeling the inner limiting membrane during wet conditions
  14. 5394
    “…Moreover, under iron deprived conditions, expression of Fur-regulated Acinetobactin siderophore genes is only induced in the dark in a BlsA-dependent manner. Finally, growth under iron deficiency is supported in the dark rather than under blue light at moderate temperatures through BlsA. …”
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    BlsA integrates light and temperature signals into iron metabolism through Fur in the human pathogen Acinetobacter baumannii
  15. 5395
    “…If patients do not respond well to pharmacotherapy, which is prescribed in a step-wise manner, other treatment strategies should be considered to improve patients’ activities of daily living and QOL.…”
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    Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians
  16. 5396
    “…Mechanical threshold and paw withdrawal latency markedly increased in a dose-dependent manner in puerarin-treated rats, especially at 7 days after model establishment. …”
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    Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury
  17. 5397
    “…Considering the large number of adverts inundating the average consumer every day, the marketing industry is seeking methods to reach clients in a more subtle manner than traditional marketing messages. One such tool is product placement. …”
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    Is Product Placement Really Worse Than Traditional Commercials? Cognitive Load and Recalling of Advertised Brands
  18. 5398
    “…G2/M-specific depletion of human Cdt1 that localizes to kinetochores in an Ndc80 complex–dependent manner leads to abnormal kMT attachments and mitotic arrest. …”
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    Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism
  19. 5399
    por Manzetti, Sergio
    Publicado 2018
    “…The numerical solutions suggest that the change in kinetic energy from one transition to the next proceeds in an undular fashion, and not in a definite manner. This suggests that any sub-atomic particle which experiences a transition from one level to the next, does so by both gaining and losing energy in an undular manner before reaching an equilibrium with a new and stabilized kinetic energy. …”
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    Derivation and Numerical analysis of an Attenuation Operator for non-relativistic waves
  20. 5400
    “…RESULTS: Our data demonstrated that polydatin inhibited the proliferation of RCC cells but not normal renal epithelial cells in a time- and dose-dependent manner. Polydatin also triggered apoptosis in a caspase-dependent manner. …”
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    Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway
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