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  1. 5401
    “…We showed that Sch B inhibited the viability and proliferation of human gallbladder cancer cells in a dose-, time -dependent manner through MTT and colony formation assays, and decrease mitochondrial membrane potential (ΔΨm) at a dose-dependent manner through flow cytometry. …”
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    Schisandrin B Induces Apoptosis and Cell Cycle Arrest of Gallbladder Cancer Cells
  2. 5402
    “…Colloidal gels can be engineered to regulate the microstructural morphology and mechanics in an independent manner because colloidal gels are formed by the aggregation of particles into a self-similar 3D network. …”
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    Colloidal Gels with Tunable Mechanomorphology Regulate Endothelial Morphogenesis
  3. 5403
    “…RESULTS: CsA upregulated Nanog transcript in HGFs in a dose-dependent manner (P < 0.05). CsA was also shown to increase Nanog protein expression in HGFs in a dose-dependent manner (P < 0.05). …”
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    Upregulation of embryonic stem cell marker Nanog in human gingival fibroblasts stimulated with cyclosporine A: An in vitro study
  4. 5404
    “…Bromelain reduced growth and proliferation of 4T1 cell as a concentration-dependence manner significantly. The survival of 4T1 cancer cells was decreased after combined treatment in a number and size-dependent manner with regard to the control group (P < 0.05). …”
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    Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells
  5. 5405
    “…We find that TRX-1 dually regulates the formation of an endurance larval stage (dauer) by interacting with the insulin pathway in a redox-independent manner and the cGMP pathway in a redox-dependent manner. …”
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    Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1
  6. 5406
    “…A novel class of small non-coding RNAs called DNA damage response RNAs (DDRNAs) generated at DNA double-strand breaks (DSBs) in a DROSHA- and DICER-dependent manner has been shown to regulate the DNA damage response (DDR). …”
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    Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs
  7. 5407
    “…The results showed that LWDH significantly extended the lifespan of C. elegans in a dose-dependent manner. LWDH also conferred protection to nematodes against oxidative stress and reduced their fat storage. …”
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    Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
  8. 5408
    “…Altogether, these results suggest that E. ferox salisb extracts exert anti-cancer effects in a p53-dependent manner.…”
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    In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway
  9. 5409
    por Song, He, Ji, Xinhua
    Publicado 2019
    “…Here, we describe the structure of a D1D2 core in complex with a 23-base pair dsRNA at pre-unwound state, revealing that two DDXs recognize a 2-turn dsRNA, each DDX mainly recognizes a single RNA strand, and conformational changes induced by ATP binding unwinds the RNA duplex in a cooperative manner.…”
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    The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
  10. 5410
    “…The nanoporous interface enables sampling of the microenvironment above in a time-dependent and spatially-resolved manner. For demonstration, the diffusional flux through the PETE membrane was characterized to understand membrane performance, and exometabolites from a growing plant root were successfully profiled in a space- and time-resolved manner. …”
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    Label-free time- and space-resolved exometabolite sampling of growing plant roots through nanoporous interfaces
  11. 5411
    “…Exposure of cortical cultures to donepezil led to a decrease in amyloid β (Aβ) protein levels in a concentration- and time-dependent manner. This decrease was not affected by concomitant treatment with acetylcholine receptor antagonists. …”
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    Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons
  12. 5412
    “…SA administration reduced plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, as well as hepatic ROS levels, in a dose-dependent manner. Moreover, SA increased the activities of the hepatic antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. …”
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    Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes
  13. 5413
    “…The plasmid curing activity of FPL was also observed in ESBL-producing E. coli in a concentration-dependent manner, suggesting that they partially contribute to the inhibition of conjugative transfer. …”
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    Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes
  14. 5414
    “…The novel sub-mitochondrially targeted Ca(2+) biosensors proved to be suitable for Ca(2+) imaging with high spatial and temporal resolution in a multi-chromatic manner allowing simultaneous measurements. These informative biosensors will facilitate efforts to dissect the complex sub-mitochondrial Ca(2+) signaling under (patho)physiological conditions.…”
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    Development and Application of Sub-Mitochondrial Targeted Ca(2 +) Biosensors
  15. 5415
    “…Gcn5, a part of the SAGA complex, binds to MBF-regulated promoters through the MBF co-activator Rep2 in a cell cycle-dependent manner and in a reverse correlation to the binding of the MBF co-repressors, Nrm1 or Yox1. …”
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    Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave
  16. 5416
    “…Spray application of Serifel, a commercial formulation of MBI600, induced responses in a dose-dependent manner. Low dosage primed plant defense by activation of SA-responsive genes. …”
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    Bacillus amyloliquefaciens MBI600 differentially induces tomato defense signaling pathways depending on plant part and dose of application
  17. 5417
    “…In conclusion, we have shown that EVs originating from different biological sources can be isolated successfully in a cost-effective and user-friendly manner with the use of aqueous two-phase systems.…”
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    Optimized Isolation of Extracellular Vesicles From Various Organic Sources Using Aqueous Two-Phase System
  18. 5418
    “…Compared to nonconjugated PUFAs, conjugated isomers exhibited an increase in the dilatation of the aortic rings (P<0.001) in a dose-dependent manner (P<0.001). In addition, nonconjugated PUFAs produced nitric oxide (NO) in a dose-dependent manner, while conjugated PUFAs did not, suggesting that their dilatation mechanism is not totally dependent on NO.…”
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    Effect of the double bond conjugation on the vascular physiology and nitric oxide production of isomers of eicosapentaenoic and docosahexaenoic acids prepared from shark oil
  19. 5419
    “…Altogether, we developed a protocol to differentiate mouse ESCs in a manner that recapitulates embryonic kidney development and showed that precise gene regulation is essential for proper differentiation to occur.…”
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    Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers
  20. 5420
    “…Immunoreactive plasma ficolin α and recombinant ficolin α also bound PRRSV-coated wells in a GlcNAc-dependent manner. These studies indicate that porcine ficolin can bind and neutralize a common arterivirus that is a major pathogen of swine.…”
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    Porcine plasma ficolin binds and reduces infectivity of porcine reproductive and respiratory syndrome virus (PRRSV) in vitro
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