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  1. 5701
    “…Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology. …”
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    The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type
  2. 5702
    “…The ability to measure changes in neuronal activity in a quantifiable and precise manner is of fundamental importance to understand neuron development and function. …”
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    Secreted Reporter Assay Enables Quantitative and Longitudinal Monitoring of Neuronal Activity
  3. 5703
    “…These results demonstrate that this device can be used to monitor the effect of antithrombotic drugs on time to occlude, and, for the first time, delivers this essential data in an unbiased and objective manner.…”
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    An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs
  4. 5704
    “…PRDM12 is expressed in a spatio-temporal manner in neuronal systems where it exerts multiple functions. …”
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    PRDM12 in Health and Diseases
  5. 5705
    “…Besides, as the dose increases, the magnitude of change shows a dose-dependent manner. Propofol exerts a negative chronotropic action on sinoatrial node pacemaker cells. …”
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    The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
  6. 5706
    “…The detection of caspase-3 marker was evident in a dose-dependent manner in all the irradiated groups, more noticeably in the taste bud cells. …”
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    Effects of dose-dependent response to gamma radiation on circumvallate papilla by expression of caspase-3 in vivo
  7. 5707
    “…To summarize, we demonstrated that Orai3 regulates cell migration through a Ca(2+)-dependent modulation of calpain activity and, in a Ca(2+)-independent manner, the actin cytoskeleton architecture via FAK.…”
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    Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms
  8. 5708
    “…CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E(2) was also reduced by CE in a dose-dependent manner. …”
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    Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE(2) Production
  9. 5709
    “…Thus, ISO suppresses cardiomyocyte glycolytic metabolism and survival by stimulating mitochondrial ROS in a p53-dependent manner. Furthermore, curcumin can efficiently rescue cardiomyocytes from these adverse effects.…”
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    Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
  10. 5710
    “…Transcription factors (TFs) bind DNA in a sequence-specific manner and are generally cell type-specific factors and/or developmental master regulators. …”
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    An RNA Polymerase III General Transcription Factor Engages in Cell Type-Specific Chromatin Looping
  11. 5711
    “…Taken together, these results suggest that the N-glycan moieties of NEGR1 are closely involved in the folding, trafficking, and homodimer formation of NEGR1 protein in a site-specific manner.…”
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    The Role of N-Glycosylation in the Intracellular Trafficking and Functionality of Neuronal Growth Regulator 1
  12. 5712
    “…In addition, niclosamide suppressed paclitaxel-induced mitochondrial dysfunction in human SH-SY5Y cells in a PINK1-dependent manner. These results suggest that niclosamide alleviates thermal hyperalgesia by attenuating paclitaxel-induced mitochondrial dysfunction. …”
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    The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy
  13. 5713
    “…Introduction The electromagnetic field (EMF) of the human brain generated by the movement of ions in the brain can be measured in a novel manner. The measurement can be completed through the skull, in a non-contact, non-invasive, continuous manner using a lightweight helmet. …”
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    Measuring the Electromagnetic Field of the Human Brain at a Distance Using a Shielded Electromagnetic Field Channel
  14. 5714
    “…AptMincle can specifically reduce trehalose-6,6-dibehenate (TDB)-induced Syk and P65 phosphorylation in vitro in a manner comparable to that of the commercially available neutralizing antibody in vitro. …”
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    Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease
  15. 5715
    “…To address this knowledge gap, here, we delineated a minimal TOPBP1 that can activate ATR at DNA double-strand breaks in a regulated manner. We named this minimal TOPBP1 “Junior” and we show that Junior is composed of just three regions: BRCT0-2, the AAD, and BRCT7&8. …”
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    Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks
  16. 5716
    “…Large convex bodies concentrate light 10–25 times in a shape-dependent manner by refraction, and small silica bodies concentrate light in a shape-insensitive, but wavelength-dependent, manner by diffraction (red light: approx. 2.3 times; blue light: approx. 1.5 times). …”
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    Size always matters, shape matters only for the big: potential optical effects of silica bodies in Selaginella
  17. 5717
    “…Membrane fusion during the entry of herpesviruses is carried out by the viral fusogen gB that is activated by its partner protein gH in some manner. The fusogenic activity of gB is controlled by its cytoplasmic (or intraviral) domain (gB(CTD)) and, according to the current model, the gB(CTD) is a trimeric, inhibitory clamp that restrains gB in the prefusion conformation. …”
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    A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion
  18. 5718
    “…These results demonstrate the utility of our approach to determine peptide-MHC binding interactions in a manner that can supplement and potentially enhance current algorithm-based approaches.…”
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    A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding
  19. 5719
    “…As a next step, to verify whether the MSCs protect against brain injury in a paracrine manner, this study was designed to estimate the efficacy of MSC-derived extracellular vesicles (MSC-EVs) in E. coli meningitis in newborn rats. …”
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    Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Attenuate Brain Injury in Escherichia coli Meningitis in Newborn Rats
  20. 5720
    “…Taken together, this study offers a robust methodology for Tetrahymena locomotion tracking in a high-throughput manner for the first time.…”
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    Establishing a High-Throughput Locomotion Tracking Method for Multiple Biological Assessments in Tetrahymena
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