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  1. 5721
    “…Using different optical biosensors to measure the activation of PTH1R and its downstream signaling, we describe here that RAMP2 acts as a specific allosteric modulator of PTH1R, shifting PTH1R to a unique preactivated state that permits faster activation in a ligand-specific manner. Moreover, RAMP2 modulates PTH1R downstream signaling in an agonist-dependent manner, most notably increasing the PTH-mediated Gi3 signaling sensitivity. …”
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    Functional modulation of PTH1R activation and signaling by RAMP2
  2. 5722
    “…Because the presence of matrix metalloproteinases and matricellular growth factors (TGF) is associated with severe LRTI, we studied the effect of RSV on ECM remodeling and found that RSV enhances the deposition of fibronectin-rich ECM by small airway epithelial cells in a manner highly dependent on the inositol requiring kinase (IRE1α)–XBP1 arm of the UPR. …”
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    The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection
  3. 5723
    “…Misfolded glycosylphosphatidylinositol-anchored prion protein (PrP) is primarily degraded in lysosomes but is often rapidly removed from the cell surface before endocytosis in a preemptive manner. However, this mechanism is poorly understood. …”
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    Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein
  4. 5724
    “…They also modulated the gut microbiota composition in a strain-dependent manner, thus decreasing Gram-negative bacteria and increasing health-promoting taxa and short-chain fatty acid levels, particularly butyric acid. …”
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    Potential Health-Promoting Effects of Two Candidate Probiotics Isolated from Infant Feces Using an Immune-Based Screening Strategy
  5. 5725
    “…This work will open new possibilities for fabrication of inexpensive non-noble metal materials in highly controlled manner for applications as bifunctional ORR/OER electrocatalysis.…”
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    Atomic layer deposition of Co(3)O(4) nanocrystals on N-doped electrospun carbon nanofibers for oxygen reduction and oxygen evolution reactions
  6. 5726
    “…Nomilin suppressed protein expression of TYR, TRP-1, TRP-2, and microphthalmia-associated transcription factor (MITF) in a concentration-dependent manner. Nomilin significantly reduced the levels of p-CREB and p-PKA at the protein level and decreased the levels of skin-whitening-related factors MITF, tyrosinase, TRP-1, and TRP-2 at the mRNA level in a concentration-dependent manner. …”
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    Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway
  7. 5727
    “…This paper provides the current state of knowledge, in an evidence-oriented manner, that the nervous system is able to participate in the carcinogenesis process by inducing biochemical, physiological, and cellular modifications involved in the hallmarks of cancer. …”
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    The Nervous System as a Regulator of Cancer Hallmarks: Insights into Therapeutic Implications
  8. 5728
    “…Furthermore, CI-1040 significantly inhibits tumor growth in different NB 3D spheroidal tumor models in a dose-dependent manner and by directly inhibiting spheroidal tumor cells. …”
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    Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth
  9. 5729
    “…In addition, C-reactive protein as a marker of systemic stress response was significantly reduced postoperatively in patients who were operated on in a robotic-assisted manner. Consequently, robotic-assisted surgery could be performed in a cost-effective manner. …”
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    Robotic-Assisted versus Laparoscopic Left Hemicolectomy—Postoperative Inflammation Status, Short-Term Outcome and Cost Effectiveness
  10. 5730
    “…The level of pollutants emitted in the city is variable, and it depends on the type and nature of the source and the manner of land development. For this reason, the purpose of the article is an attempt at a spatial (inner) diversification of a city in terms of air quality, using a study of perception and semantic differentials (SD). …”
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    Verification of the Perception of the Local Community concerning Air Quality Using ADMS-Roads Modeling
  11. 5731
    “…The present results indicate that LPA in serum has an AJC organization–promoting activity in a manner dependent on or independent of AJ proteins.…”
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    Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization
  12. 5732
    “…We found that Cd decreased cell viability in a concentration-dependent manner, with a median lethal concentration (LC(50)) of 11 µM. …”
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    Mechanisms of Cd-Induced Cytotoxicity in Normal Human Skin Keratinocytes: Implication for Human Health
  13. 5733
    “…As gastric gland carcinoma cell line MKN-45 was the research subject, mechanical force loading conditions could trigger apoptosis of the cells in a stimulation duration time-dependent manner. Cell apoptotic rates were positively related to the duration time. …”
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    Mechanobiology Platform Realized Using Photomechanical Mxene Nanocomposites: Bilayer Photoactuator Design and In Vitro Mechanical Forces Stimulation
  14. 5734
    “…Expression of astrocytic core homeostatic genes was also altered in a brain region-specific manner and correlated with neuronal activity, indicating that astrocytes may compensate or exacerbate neuronal dysfunction. …”
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    Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice
  15. 5735
    “…It had been reported that yeast Pus1 is a multiple-site-specific enzyme that synthesizes Ψ34 and Ψ36 in tRNA(Ile)(UAU) in an intron-dependent manner. Unexpectedly, our biochemical experiments showed that the C. merolae ortholog of Pus1 pseudouridylated an intronless tRNA(Ile)(UAU) and that the modification position was determined to be 55 which is the target of Pus4 but not Pus1 in yeast. …”
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    Intron-Dependent or Independent Pseudouridylation of Precursor tRNA Containing Atypical Introns in Cyanidioschyzon merolae
  16. 5736
    “…Planispine A was found to inhibit cancer cell proliferation in a dose-dependent manner and to sensitize the cancer cells to cisplatin-augmented apoptotic cell death, in a caspase-dependent manner. …”
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    Planispine A Sensitized Cancer Cells to Cisplatin by Inhibiting the Fanconi Anemia Pathway
  17. 5737
    “…Therefore, we strongly recommend bicaval anastomoses, ideally in a modified manner.…”
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    Optimizing Anastomoses Technique in Orthotopic Heart Transplantation: Comparison of Biatrial, Bicaval and Modified Bicaval Technique
  18. 5738
    “…These multifunctional nanosystems have shown to convert NIR radiation into heat and release charged drugs in a remote-controlled manner. Then, the biocompatibility and synergistic effects of a chemo-phototherapy combination, as well the receptor-mediated internalization, were evaluated by an in vitro test on HepG2, HuH7, and NHDF. …”
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    Galactosylated Polymer/Gold Nanorods Nanocomposites for Sustained and Pulsed Chemo-Photothermal Treatments of Hepatocarcinoma
  19. 5739
    “…The activities of superoxide dismutase and glutathione were also found to decrease in a dose-dependent manner. The percentage of apoptotic cells was found to increase in a dose-dependent manner in MCF-7 cells. …”
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    In Vitro Anticancer Activity of Methanolic Extract of Justicia adhatoda Leaves with Special Emphasis on Human Breast Cancer Cell Line
  20. 5740
    “…The most common nonclinical complaints included bedside manner (65%) and limited time with providers (19%). …”
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    Analysis of Negative Reviews of Orthopedic Oncology Surgeons: An Investigation of Reviews from Healthgrades, Vitals, and Google
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