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  1. 5881
    “…Single administration of HD0471953 showed improved glycemic control with a dose-dependent manner in OGTT with normal mice, and the insulin and GLP-1 were also increased. …”
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    In Vivo Efficacy of HD0471953: A Novel GPR119 Agonist for the Treatment of Type 2 Diabetes Mellitus
  2. 5882
    “…RESULTS: Treatment with HGF increased c-Met phosphorylation in a dose-dependent manner, as well as increasing cell proliferation. …”
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    Hepatocyte Growth Factor/c-Met Signaling in Regulating Urokinase Plasminogen Activator in Human Stomach Cancer: A Potential Therapeutic Target for Human Stomach Cancer
  3. 5883
    “…A dendrogram based on hierarchical clustering analysis of the FT-IR spectral data on ginseng leaves showed that leaf samples were initially segregated into three groups in a cultivation age-dependent manner. Then, within the same cultivation age group, leaf samples were clustered into four subgroups in a cultivar-dependent manner. …”
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    Discrimination of cultivation ages and cultivars of ginseng leaves using Fourier transform infrared spectroscopy combined with multivariate analysis
  4. 5884
    “…Estragole blocked the generation of action potentials in cells with or without inflexions on their descendant (repolarization) phase (N(inf) and N(0) neurons, respectively) in a concentration-dependent manner. The resting potentials and input resistances of N(inf) and N(0) cells were not altered by estragole (2, 4, and 6 mM). …”
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    Estragole blocks neuronal excitability by direct inhibition of Na(+) channels
  5. 5885
    “…CONCLUSIONS: Different speech sounds evoked different P1-N1-P2 patterns in the place and the manner of articulation in terms of interamplitude, but not of the latency and interlatency although further studies should be followed.…”
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    The Cortical Evoked Response Elicited by Nine Plosives in Normal Hearing Listeners
  6. 5886
    “…Previous pharmacological experiments in our laboratory suggested that AVP regulates play in a sex- and brain region-specific manner in juvenile rats. Here we investigate the role of specific AVP systems in the emergence of social play. …”
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    Sexually dimorphic role for vasopressin in the development of social play
  7. 5887
    “…Alternative pre-messenger RNA splicing remodels the human transcriptome in a spatiotemporal manner during normal development and differentiation. …”
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    A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis
  8. 5888
    “…Perilla oil delayed the FeCl(3)-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. …”
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    Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation
  9. 5889
    “…Our results demonstrate that nitric oxide has a beneficial effect on MIN-6 cells in a concentration-dependent manner.…”
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    Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix
  10. 5890
    “…Furthermore, p50(Nesp1) was required for miRNA-mediated silencing and interacted with core miRISC silencers Ago2 and Rck/p54 in an RNA-dependent manner and with GW182 in a microtubule-dependent manner. …”
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    Mammalian microtubule P-body dynamics are mediated by nesprin-1
  11. 5891
    “…Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP and protein kinase A signaling, up-regulated beta cell intermediary metabolism may also play a role in incretin-stimulated insulin secretion. …”
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    Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans
  12. 5892
    “…Furthermore, glabridin induced apoptosis of HL-60 cells through caspases-3, -8, and -9 activations and PARP cleavage in dose- and time-dependent manner. Moreover, western blot analysis also showed that glabridin increase phosphorylation of ERK1/2, p38 MAPK and JNK1/2 in dose- and time-dependent manner. …”
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    Glabridin Mediate Caspases Activation and Induces Apoptosis through JNK1/2 and p38 MAPK Pathway in Human Promyelocytic Leukemia Cells
  13. 5893
    “…Colorectal tumorigenesis is ascribed to the activity of Wnt signaling pathway in a ligand-independent manner mainly through APC and CTNNB1 gene mutations and in a ligand-dependent manner through low expression of Wnt inhibitors such as WNT inhibitory factor 1 (WIF1) and secreted frizzled related protein 1 (SFRP1). …”
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    Coexpression of SFRP1 and WIF1 as a Prognostic Predictor of Favorable Outcomes in Patients with Colorectal Carcinoma
  14. 5894
    por Gupta, Varun, Warner, Jonathan R.
    Publicado 2014
    “…Of the 376 introns in the RP genes, a single one is alternatively spliced in a tissue-specific manner.…”
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    Ribosome-omics of the human ribosome
  15. 5895
    “…It also prevented the increase in claudin-1 in a concentration dependent manner up to 1 µM. TLR2 stimulation led to an increase in phosphorylation of atypical PKC ζ, which was prevented by the pseudosubstrate inhibitor in a concentration dependent manner. …”
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    Toll-like receptor 2 regulates the barrier function of human bronchial epithelial monolayers through atypical protein kinase C zeta, and an increase in expression of claudin-1
  16. 5896
    “…Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent manner. Remarkably, the gas1Δ mutation induces nuclear localization of Msn2/4 and stimulates the expression of PNC1, a gene encoding a nicotinamidase that functions as a Sir2 activator. …”
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    The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae
  17. 5897
    “…The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually. …”
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    Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea
  18. 5898
    “…It was found that CTD inhibited the proliferation of the human gastric cancer SGC-7901 and BGC-823 cells in a dose- and time-dependent manner in vitro. CTD also induced G(2)/M phase arrest and cellular apoptosis in a dose-dependent manner. …”
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    Cantharidin induces G(2)/M phase arrest and apoptosis in human gastric cancer SGC-7901 and BGC-823 cells
  19. 5899
    “…We propose a model where the silencing proteins AGO4, IDN2 and DRM2 bind to lncRNA in a stepwise manner, resulting in DNA methylation of RdDM target loci.…”
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    RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA
  20. 5900
    “…CONCLUSION: This study demonstrated that BUM into Fengbu (GV16) increased the rCBF in a dose-dependent manner in the normal state; furthermore, it improved the stability of the rCBF in the ischemic state upon reperfusion. …”
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    Calculus Bovis-Fel Uris-Moschus Pharmacopuncture’s Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats
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