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  1. 5901
    “…Naip1-6(Δ/Δ) mice developed increased colorectal tumors, in an epithelial-intrinsic manner, in a model of colitis-associated cancer. Increased tumorigenesis, however, was not driven by an exacerbated inflammatory response. …”
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    Epithelial NAIPs protect against colonic tumorigenesis
  2. 5902
    “…ERVs are epigenetically silenced during development, yet the cellular factors recognizing ERVs in a sequence-specific manner remain elusive. Here we demonstrate that ZFP809, a member of the Krüppel-associated box zinc finger protein (KRAB-ZFP) family, initiates the silencing of ERVs in a sequence-specific manner via recruitment of heterochromatin-inducing complexes. …”
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    The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses
  3. 5903
    “…In this study, we found that paclitaxel causes acute pain in rodents in a dose-dependent manner. The paclitaxel-induced acute pain occurs within 2 hrs after a single intravenous injection of paclitaxel. …”
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    Paclitaxel induces acute pain via directly activating toll like receptor 4
  4. 5904
    “…Cell viability was significantly decreased by H(2)O(2) in a dose-dependent manner. Additionally, H(2)O(2) treatment increased Bax, decreased Bcl-2, and promoted PARP-1 cleavage in a dose-dependent manner. …”
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    Protective effect of butylated hydroxylanisole against hydrogen peroxide-induced apoptosis in primary cultured mouse hepatocytes
  5. 5905
    “…Delayed rearterialization caused temporary injury to bile canaliculi and intrahepatic bile duct in a time-dependent manner. Injury could be fully treated in succeeding months. …”
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    Delayed rearterialization unlikely leads to nonanastomotic stricture but causes temporary injury on bile duct after liver transplantation
  6. 5906
    “…SA also overcame As(V) induced oxidative stress and modulated the activities of antioxidant enzymes in a differential manner in shoots. As treatment hampered the translocation of Fe in the shoot which was compensated by the SA treatment. …”
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    Salicylic acid modulates arsenic toxicity by reducing its root to shoot translocation in rice (Oryza sativa L.)
  7. 5907
    “…The computer prediction was confirmed by an in vitro kinase assay in which EGCG inhibited RSK2 activity in a dose-dependent manner. Pull-down assay results showed that EGCG could bind with RSK2 at both kinase catalytic domains in vitro and ex vivo. …”
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    Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG)
  8. 5908
    “…Cell proliferation and apoptosis of human endometrial stromal cells (HESCs) and glandular cells (HEGCs) treated with LNG in a dose- and time-dependent manner. GJIC change and further total Cx43 and serine 368 and 255 phosphorylated Cx43 were measured. …”
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    Levonorgestrel Inhibits Human Endometrial Cell Proliferation through the Upregulation of Gap Junctional Intercellular Communication via the Nuclear Translocation of Ser255 Phosphorylated Cx43
  9. 5909
    “…Result of flow cytometry demonstrated that GE at a 25 μM concentration induces apoptosis significantly in a time-dependent manner. The percentage of apoptotic cells at different times were 44, 56, and 60%, respectively (P < 0.001). …”
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    Inhibitory Effect of Genistein on PLC/PRF5 Hepatocellular Carcinoma Cell Line
  10. 5910
    “…We focused on the implications of the manner in which this discretization is implemented. …”
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    The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis
  11. 5911
    por Furukawa, Kentaro, Hohmann, Stefan
    Publicado 2015
    “…Second, combinatorial integration of different genetic parts including the histidine kinases, a pathway activator and chemically regulated promoters enables control of yeast growth and/or gene expression in a two-input Boolean logic manner. Finally, we implemented a genetic ‘suicide attack’ system, in which engineered cells eliminate target cells and themselves in a specific and controllable manner. …”
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    A fungicide-responsive kinase as a tool for synthetic cell fate regulation
  12. 5912
    “…TNF-α production was reduced in a dose-dependent manner by treatment with wortmannin and PD98059, whereas it was increased by SP600125. …”
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    Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
  13. 5913
    “…In summary, epigenetic mapping of active enhancers presents a promising and unbiased approach for identification of novel disease genes in a cell type-selective manner.…”
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    Cell type-selective disease-association of genes under high regulatory load
  14. 5914
    “…Adenine also attenuated NF-κB targeting of gene expression in a dose-dependent manner and decreased monocyte adhesion to HUVECs following tumor necrosis factor (TNF-α) treatment. …”
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    Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells
  15. 5915
    “…P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of breast cancer cells. …”
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    PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion
  16. 5916
    “…The present study was designed to determine whether PEE can increase the susceptibility of high-fat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear model analysis. …”
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    Sex-specific increase in susceptibility to metabolic syndrome in adult offspring after prenatal ethanol exposure with post-weaning high-fat diet
  17. 5917
    “…Furthermore REST knockdown increases glucose consumption and lactate production in a HIF-1α- (but not HIF-2α-) dependent manner. Finally, REST promotes the resolution of HIF-1α protein expression in prolonged hypoxia. …”
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    REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia
  18. 5918
    “…Experimental results revealed that the flow of culture medium could be pneumatically driven in a flow-rate uniform manner. We used the system to successfully perform a perfusion 3-D cell culture of mesenchymal stem cells (MSCs) for up to 16 days. …”
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    Development of a pneumatically driven active cover lid for multi-well microplates for use in perfusion three-dimensional cell culture
  19. 5919
    “…On the TGF-β1-SF-CS and SF-CS scaffolds, the cell adhesion rate increased in a time-dependent manner. Scanning electron microscopy revealed that the cells grew actively and exhibited normal morphological features with multiple fissions, and granular and filamentous substrates were observed surrounding the cells. …”
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    In vitro culture of hFOB1.19 osteoblast cells on TGF-β1-SF-CS three-dimensional scaffolds
  20. 5920
    “…PK profile analysis showed that sera steady concentration could be reached in dose-proportional manner, except volume of distribution (V(d)) and clearance (CL), which reached peak values at 250 mg administration cohort. …”
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    A phase I dose-escalation study of a biosimilar trastuzumab in Chinese metastasis breast cancer patients
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