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5981por Brown, LaShardai N., Xing, Yazhi, Noble, Kenyaria V., Barth, Jeremy L., Panganiban, Clarisse H., Smythe, Nancy M., Bridges, Mary C., Zhu, Juhong, Lang, Hainan“…This relay of information requires HCs to be innervated by spiral ganglion neurons (SGNs) in an exclusive manner and SGNs to be ensheathed by myelinating and non-myelinating glial cells. …”
Publicado 2017
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5982por Guyon, Ludivine, Pirrotta, Marc, Duskova, Katerina, Granzhan, Anton, Teulade-Fichou, Marie-Paule, Monchaud, David“…The quest for chemicals able to operate at selected genomic loci in a spatiotemporally controlled manner is desirable to create manageable DNA damages. …”
Publicado 2018
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5983por Widmer, Giovanni, Ferrer, Lluís, Favrot, Claude, Paps, Judy, Huynh, Kevin, Olivry, Thierry“…The diversity and composition of cutaneous microbiota was not impacted in a detectable manner by any of the treatments. As observed for the bacterial microbiota, Malassezia populations were not affected by treatment. …”
Publicado 2018
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5984por Xia, Hongwei, Dai, Xinyu, Yu, Huangfei, Zhou, Sheng, Fan, Zhenghai, Wei, Guoqing, Tang, Qiulin, Gong, Qiyong, Bi, Feng“…Therefore, the EGFR-PI3K-PDK1 pathway could activate the YAP signaling, and the activated EGFR signaling could promote the HCC cell growth in a YAP-independent manner. Combined use of FDA-approved inhibitors to simultaneously target YAP and EGFR signaling presented several promising therapeutic approaches for HCC treatment.…”
Publicado 2018
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5985por Rahnasto-Rilla, Minna, Tyni, Jonna, Huovinen, Marjo, Jarho, Elina, Kulikowicz, Tomasz, Ravichandran, Sarangan, A. Bohr, Vilhelm, Ferrucci, Luigi, Lahtela-Kakkonen, Maija, Moaddel, Ruin“…Inhibitors likely bind in a manner that could disturb NAD(+) binding. The putative activator binding site was found next to a loop near the acetylated peptide substrate binding site. …”
Publicado 2018
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5986por Gu, Mian, Zhang, Jun, Li, Huanhuan, Meng, Daqian, Li, Ran, Dai, Xiaoli, Wang, Shichao, Liu, Wei, Qu, Hongye, xu, Guohua“…Furthermore, MYB1 affected the elongation of the primary root in a Pi-dependent manner and lateral roots in a Pi-independent manner. …”
Publicado 2017
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5987por Shan, Haiyan, Chu, Yang, Chang, Pan, Yang, Lijun, Wang, Yi, Zhu, Shaohua, Zhang, Mingyang, Tao, Luyang“…Expression of the endogenous H(2)S-producing enzymes, cystathionine-β-synthase and 3-mercaptopyruvate sulfurtransferase, decreased in a dose-dependent manner following NaN(3) treatment. Pretreatment with H(2)S markedly attenuated the NaN(3)-induced cell viability loss and autophagic cell death in a dose-dependent manner. …”
Publicado 2017
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5988por Yang, Libang, Herrera, Jeremy, Gilbertsen, Adam, Xia, Hong, Smith, Karen, Benyumov, Alexey, Bitterman, Peter B., Henke, Craig A.“…IL-8 functioned in an autocrine manner promoting IPF MPC self-renewal and the proliferation and motility of IPF MPC progeny. …”
Publicado 2018
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5989por Han, Ying‐Chao, Ma, Bin, Guo, Song, Yang, Mingjie, Li, Li‐Jun, Wang, Shan‐Jin, Tan, Jun“…Both OCN and Runx2 expression levels were significantly increased in a dose‐ and time‐dependent manner. Leptin activated ERK1/2 and STAT3 phosphorylation in a time‐dependent manner. …”
Publicado 2018
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5990por Hamasaki, Shinichi, Kobori, Takuro, Yamazaki, Yui, Kitaura, Atsuhiro, Niwa, Atsuko, Nishinaka, Takashi, Nishibori, Masahiro, Mori, Shuji, Nakao, Shinichi, Takahashi, Hideo“…Moreover, an SR-A antagonistic ligand, fucoidan, also attenuated the AGE-2- and AGE-3-evoked uptake in a concentration-dependent manner. These results indicated that SR-A stimulation, at least in part, plays a role in AGE uptake.…”
Publicado 2018
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5991“…System-associated factors, physician-associated factors, and patient-associated factors interact in a complex manner that contributes to the reported disparities. …”
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5992“…CONCLUSIONS: HR occurs frequently at innate GT microsatellites in normal somatic cells and germ cells in a similar manner. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4758-y) contains supplementary material, which is available to authorized users.…”
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5993por Karny, Avishai, Zinger, Assaf, Kajal, Ashima, Shainsky-Roitman, Janna, Schroeder, Avi“…We show that the nanoparticles – liposomes composed of plant-derived lipids, penetrate the leaf and translocate in a bidirectional manner, distributing to other leaves and to the roots. …”
Publicado 2018
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5994“…Similar to the onset phase of inflammation, its resolution is a process that unfolds in a manner that is coordinated and regulated by a panel of mediators. …”
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5995por Sumi, Chisato, Okamoto, Akihisa, Tanaka, Hiromasa, Kusunoki, Munenori, Shoji, Tomohiro, Uba, Takeo, Adachi, Takehiko, Iwai, Teppei, Nishi, Kenichiro, Harada, Hiroshi, Bono, Hidemasa, Matsuo, Yoshiyuki, Hirota, Kiichi“…It is also indicated that propofol induces the cell death in a reactive oxygen species (ROS)-dependent manner. Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death. …”
Publicado 2018
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5996por Bian, Wenxin, Meng, Buliang, Li, Xiaojie, Wang, Siyuan, Cao, Xiaoqing, Liu, Naixin, Yang, Meifeng, Tang, Jing, Wang, Ying, Yang, Xinwang“…Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibroblasts in a dose- and time-denpendent manner. However, OA-GL21 had no significant effect on the proliferation of these two cells. …”
Publicado 2018
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5997por Agnarelli, Alessandro, Natali, Marco, Garcia-Gil, Mercedes, Pesi, Rossana, Tozzi, Maria Grazia, Ippolito, Chiara, Bernardini, Nunzia, Vignali, Robert, Batistoni, Renata, Bianucci, Anna Maria, Marracci, Silvia“…Finally, we observed that berberine modulates the expression profile of genes involved in different pathways of tumorigenesis in a cell line-specific manner. These findings have valuable implications for understanding the complex functional interactions between berberine and specific cell types.…”
Publicado 2018
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5998por Zhang, Demao, Jing, Junjun, Lou, Feng, Li, Ruimin, Ping, Yilin, Yu, Fanyuan, Wu, Fanzi, Yang, Xiao, Xu, Ruoshi, Li, Feifei, Wang, Ke, Bai, Mingru, Pi, Caixia, Xie, Jing, Zheng, Liwei, Ye, Ling, Zhou, Xuedong“…Moreover, osteoblast/osteoclast co-culture demonstrated that SIRT6 regulated osteoclast mainly through osteoblast paracrine manner, rather than osteoclast-autonomous behavior. …”
Publicado 2018
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5999por Alfieri, Mariaevelina, Vaccaro, Maria Carmela, Cappetta, Elisa, Ambrosone, Alfredo, De Tommasi, Nunziatina, Leone, Antonietta“…The content of total abietane diterpenes was enhanced in all overexpressing lines, although in a variable manner due to a negative pleiotropic effect on HR growth. …”
Publicado 2018
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6000“…Intrinsic terminators are composed of a stem-loop RNA structure followed by a uridine stretch and are known to terminate in a precise manner. In contrast, Rho-dependent terminators have more loosely defined characteristics and are thought to terminate in a diffuse manner. …”
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