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  1. 5981
    “…This relay of information requires HCs to be innervated by spiral ganglion neurons (SGNs) in an exclusive manner and SGNs to be ensheathed by myelinating and non-myelinating glial cells. …”
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  2. 5982
    “…The quest for chemicals able to operate at selected genomic loci in a spatiotemporally controlled manner is desirable to create manageable DNA damages. …”
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  3. 5983
    “…The diversity and composition of cutaneous microbiota was not impacted in a detectable manner by any of the treatments. As observed for the bacterial microbiota, Malassezia populations were not affected by treatment. …”
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  4. 5984
    “…Therefore, the EGFR-PI3K-PDK1 pathway could activate the YAP signaling, and the activated EGFR signaling could promote the HCC cell growth in a YAP-independent manner. Combined use of FDA-approved inhibitors to simultaneously target YAP and EGFR signaling presented several promising therapeutic approaches for HCC treatment.…”
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  5. 5985
    “…Inhibitors likely bind in a manner that could disturb NAD(+) binding. The putative activator binding site was found next to a loop near the acetylated peptide substrate binding site. …”
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  6. 5986
  7. 5987
    “…Expression of the endogenous H(2)S-producing enzymes, cystathionine-β-synthase and 3-mercaptopyruvate sulfurtransferase, decreased in a dose-dependent manner following NaN(3) treatment. Pretreatment with H(2)S markedly attenuated the NaN(3)-induced cell viability loss and autophagic cell death in a dose-dependent manner. …”
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  8. 5988
    “…IL-8 functioned in an autocrine manner promoting IPF MPC self-renewal and the proliferation and motility of IPF MPC progeny. …”
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  9. 5989
    “…Both OCN and Runx2 expression levels were significantly increased in a dose‐ and time‐dependent manner. Leptin activated ERK1/2 and STAT3 phosphorylation in a time‐dependent manner. …”
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  10. 5990
    “…Moreover, an SR-A antagonistic ligand, fucoidan, also attenuated the AGE-2- and AGE-3-evoked uptake in a concentration-dependent manner. These results indicated that SR-A stimulation, at least in part, plays a role in AGE uptake.…”
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  11. 5991
    “…System-associated factors, physician-associated factors, and patient-associated factors interact in a complex manner that contributes to the reported disparities. …”
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  12. 5992
    “…CONCLUSIONS: HR occurs frequently at innate GT microsatellites in normal somatic cells and germ cells in a similar manner. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4758-y) contains supplementary material, which is available to authorized users.…”
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  13. 5993
    “…We show that the nanoparticles – liposomes composed of plant-derived lipids, penetrate the leaf and translocate in a bidirectional manner, distributing to other leaves and to the roots. …”
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  14. 5994
    por Gaudin, A., Tolar, M., Peters, O. A.
    Publicado 2018
    “…Similar to the onset phase of inflammation, its resolution is a process that unfolds in a manner that is coordinated and regulated by a panel of mediators. …”
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  15. 5995
    “…It is also indicated that propofol induces the cell death in a reactive oxygen species (ROS)-dependent manner. Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death. …”
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  16. 5996
    “…Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibroblasts in a dose- and time-denpendent manner. However, OA-GL21 had no significant effect on the proliferation of these two cells. …”
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  17. 5997
    “…Finally, we observed that berberine modulates the expression profile of genes involved in different pathways of tumorigenesis in a cell line-specific manner. These findings have valuable implications for understanding the complex functional interactions between berberine and specific cell types.…”
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  18. 5998
    “…Moreover, osteoblast/osteoclast co-culture demonstrated that SIRT6 regulated osteoclast mainly through osteoblast paracrine manner, rather than osteoclast-autonomous behavior. …”
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  19. 5999
  20. 6000
    por Dar, Daniel, Sorek, Rotem
    Publicado 2018
    “…Intrinsic terminators are composed of a stem-loop RNA structure followed by a uridine stretch and are known to terminate in a precise manner. In contrast, Rho-dependent terminators have more loosely defined characteristics and are thought to terminate in a diffuse manner. …”
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