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  1. 6021
    “…Both Tanshinone IIA and cisplatin inhibit non‐small‐cell lung cancer cell growth in a time‐ and dose‐dependent manner. When Tanshinone IIA was combined with cisplatin at a ratio of 20:1, they were observed to exert a synergistic inhibitory effect on non‐small‐cell lung cancer cells. …”
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    Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway
  2. 6022
    “…Interestingly, pAKT1-Ser(473) activity regulates both ciliary synthesis/assembly and disassembly in a MLN4924 dependent manner, whereas pAKT-Thr(308) determines the ciliary length in MLN4924-independent but VHL-dependent manner. …”
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    Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1
  3. 6023
    “…Further analysis revealed that a faction of circRNAs is differentially expressed (DE) in a developmental stage-specific manner. The host genes of DE circRNAs are markedly enriched to multiple signaling pathways associated with cumulus cell function and oocyte maturation. …”
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    Circular RNA profiling in the oocyte and cumulus cells reveals that circARMC4 is essential for porcine oocyte maturation
  4. 6024
    “…The results showed that cell proliferation and viability were inhibited in a dose- and time-dependent manner. The similar phenomenon was also found in vivo. …”
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    Osthole inhibits the progression of human gallbladder cancer cells through JAK/STAT3 signal pathway both in vitro and in vivo
  5. 6025
    “…BD was indicated to reduce cell viability in a dose- and time-dependent manner, whilst cell invasion and migration were also significantly inhibited in a dose-dependent manner. …”
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    The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells
  6. 6026
    por Fang, Qing, Jiang, Siyi, Li, Chengyuan
    Publicado 2019
    “…Evo also increased cytochrome C expression and ROS production in cytosol in a dose-dependent manner, which was abolished by MitoTEMPO cotreatment. …”
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    Evodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway
  7. 6027
    por Gyongyosi, Laszlo, Imre, Sandor
    Publicado 2020
    “…We prove that the local unitaries of an HRE quantum memory achieve the optimization of the readout procedure in an unsupervised manner without the use of any labeled data or training sequences. …”
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    Optimizing High-Efficiency Quantum Memory with Quantum Machine Learning for Near-Term Quantum Devices
  8. 6028
    “…PSR staining indicated that collagen was found throughout the ovarian stroma in an age‐dependent manner in Tinagl1(flox/flox) females, whereas those distributions were delayed to 14‐15 months in Tinagl1 (−/−) females. …”
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    Tubulointerstitial nephritis antigen‐like 1 deficiency alleviates age‐dependent depressed ovulation associated with ovarian collagen deposition in mice
  9. 6029
    “…As the kit succeeded in reducing nonspecific IgG binding to the ELISA plate, the predictive performance shown in the training study to discriminate aPAP patients from healthy subjects was perfect, providing a cut-off value of 1.65 U·mL(−1) in 78 patients with aPAP and 90 healthy subjects in an operator-blinded manner using logistic regression analysis. As in the validation study, serum samples from another 213 patients with aPAP were also blinded and evaluated in an operator-blinded manner against external 207 samples from patients with other types of PAP and patients exhibiting various ground-glass opacities on chest high-resolution computed tomography that require discrimination from PAP. …”
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    Validation of a new serum granulocyte–macrophage colony-stimulating factor autoantibody testing kit
  10. 6030
    “…In addition, acting through WNT3A secretion, LINC00662 activated Wnt/β‐catenin signaling in macrophages in a paracrine manner and further promoted M2 macrophage polarization. …”
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    Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling
  11. 6031
    “…Hematologic cancer cell lines (Raji, K562 and Jurkat) were treated with IFA in a dose-dependent manner and proliferation was measured by a cell proliferation assay. …”
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    Isoferulic acid inhibits human leukemia cell growth through induction of G2/M-phase arrest and inhibition of Akt/mTOR signaling
  12. 6032
    “…Furthermore, we show that Sox2 and fibronectin are co-expressed in proregenerative Schwann cells in vivo in a time-dependent manner during sciatic nerve regeneration. Taken together, our results provide new insights into the mechanisms by which Schwann cells regulate their own extracellular microenvironment in a Sox2-dependent manner to ensure the proper migration of neurons.…”
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    Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis
  13. 6033
    “…Here we show that Rif2 inhibits MRX association to DSBs in a manner dependent on Rap1, which binds to DSBs and promotes Rif2 association to them. …”
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    DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends
  14. 6034
    “…We found that TAP7f inhibited cell adhesion, migration and invasion in a dose-dependent manner. Additionally, we demonstrated that TAP7f downregulated integrin αvβ3 expression and Wnt/β-catenin pathway, a signaling cascade commonly related to tumor invasion and metastasis. …”
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    A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway
  15. 6035
    “…Perturbed NMD modulated keratinocyte homeostasis in an AREG-dependent but nonidentical manner, which highlighted the unique characteristics of NMD in keratinocytes. …”
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    Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG
  16. 6036
    “…In conclusion, both feature selection and classification are feasible in a distributed manner using radiomics data, which opens new possibility for training more reliable radiomics models.…”
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    Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer
  17. 6037
    “…One potential explanation for the differential cellular response to these drugs is in the manner by which cells process TOP2ccs. Cells are thought to remove TOP2ccs primarily by proteolytic degradation followed by DNA DSB repair. …”
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    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
  18. 6038
    “…Colony formation assays confirmed that cinobufagin exerted potent antitumor activity in a dose-dependent manner. We found that cinobufagin could induce cell apoptosis and upregulate the expression of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase (PARP), and cleaved caspase-9 in vivo and in vitro. …”
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    Study of Cinobufagin as a Promising Anticancer Agent in Uveal Melanoma Through Intrinsic Apoptosis Pathway
  19. 6039
    por Kim, Gi Dae
    Publicado 2020
    “…Treatment with HC (40 μg/mL) increased migration of ECs, and increased phosphorylation of extracellular signal-regulated kinases and p38 in a dose-dependent manner. Following HG treatment (30 mM), HC significantly decreased the number of senescence-associated β-galactosidase positive cells, which are the biomarkers for aging, in a dose-dependent manner. …”
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    Sirt1-Mediated Anti-Aging Effects of Houttuynia cordata Extract in a High Glucose-Induced Endothelial Cell-Aging Model
  20. 6040
    “…An empirical mode decomposition (EMD) is used, in a data-driven manner, to generate reference signals that can be incorporated into a constrained version of ICA (cICA), thereby eliminating the inherent ambiguities of ICA. …”
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    A Constrained ICA-EMD Model for Group Level fMRI Analysis
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