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  1. 6041
    “…However, there was no efficient method that can consider the two different types of graphs in an end-to-end manner. RESULTS: We give a new formulation of the chemical network prediction problem as a link prediction problem in a graph of graphs (GoG) which can represent the hierarchical structure consisting of compound graphs and an inter-compound graph. …”
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    Dual graph convolutional neural network for predicting chemical networks
  2. 6042
    “…Recent revolutionary advancements in sequencing technologies have made it possible to obtain mass quantities of genome-scale sequence data in a cost-effective manner and have drastically altered molecular biological studies. …”
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    TASUKE+: a web-based platform for exploring GWAS results and large-scale resequencing data
  3. 6043
    “…Gaze-contingent eyetracking paradigms provide a useful tool to analyze social agency in an experimentally controlled manner, but the current methods are lacking in terms of their ecological validity. …”
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    A naturalistic paradigm simulating gaze-based social interactions for the investigation of social agency
  4. 6044
    “…Thus, NO regulates sGC in a bimodal manner, acutely stimulating and chronically inhibiting, as part of self-limiting direct feedback that is cGMP independent. …”
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    Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
  5. 6045
    “…These tissues exhibited distinct BMP profiles that were regulated by the nutritional state in a tissue-specific manner. Insulin treatment was not sufficient to mimic refeeding-induced changes in tissue BMP levels, indicating that BMP metabolism is regulated by other hormonal or nutritional factors. …”
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    Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice
  6. 6046
    “…A recovery was achieved in all cases, although in a variable manner. CONCLUSIONS: Whether or not and in which manner the pharmacomodulation of the renin-angiotensin system may had affect the clinical course of the reported six COVID-19 patients affected by stroke has to be still clarified. …”
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    Targeting of renin-angiotensin system in COVID-19 patients affected by stroke: Emerging concerns about detrimental vs. benefit effect
  7. 6047
    “…Levodopa inhibited the development of LIM in a dose-dependent manner similar to its inhibition of FDM when administered via intravitreal injections or topical eye drops. …”
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    Levodopa inhibits the development of lens-induced myopia in chicks
  8. 6048
    “…Inflammatory symptoms and apoptotic injuries to experimental rats in a group that is treated with HPA treated are decreased in a dose-dependent manner after UVB exposure (300 mJ/cm(2)) for 15 min in vivo, compared to the vehicle control group. …”
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    Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In Vivo
  9. 6049
    “…CONCLUSION: Linking radiomics and biological correlates in a targeted manner could potentially improve the clinical management of ovarian cancer. …”
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    Integrative radiogenomics for virtual biopsy and treatment monitoring in ovarian cancer
  10. 6050
    “…Here we show that Aurora B and Bub1 at the centromere/kinetochore regulate both kinase activities one another in an inter-kinetochore distance-dependent manner, indicating a positive feedback loop. We further show that the centromeric pool of SET on Sgo2 depends on Bub1 kinase activity, and the centromeric localization of SET decreases in a distance-dependent manner, thereby inactivating Aurora B in metaphase. …”
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    SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres
  11. 6051
    “…In parallel, FA exposure promoted T cell differentiation into regulatory T cells in a dose-dependent manner supported by the expression of calcineurin and NFAT1. …”
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    Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway
  12. 6052
    “…Primary Siwi‐piRISC production occurs on the outer mitochondrial membrane in an Ago3‐independent manner, where Tudor domain‐containing Papi binds unloaded Siwi via its symmetrical dimethylarginines (sDMAs). …”
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    Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori
  13. 6053
    “…RESULTS: DSF inhibited cell growth of GBM U251 and LN229 cell lines in vitro in a concentration-dependent manner. Flow cytometry demonstrated that DSF caused G0-G1 growth arrest. …”
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    Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma
  14. 6054
    “…Calcium ionophore-induced EVs exert cytoprotection by inducing HO-1 in a TLR4-independent manner.…”
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    Calcium Ionophore-Induced Extracellular Vesicles Mediate Cytoprotection against Simulated Ischemia/Reperfusion Injury in Cardiomyocyte-Derived Cell Lines by Inducing Heme Oxygenase 1
  15. 6055
    “…As the number of infected patients decrease across Canada, elective surgeries are being restarted in a staged manner. Since Otolaryngologists – Head & Neck Surgeons manage surgical diseases of the upper aerodigestive tract where the highest viral load reside, it is imperative that these surgeries resume in a safe manner. …”
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    CSO (Canadian Society of Otolaryngology - Head & Neck Surgery) position paper on rhinologic and skull base surgery during the COVID-19 pandemic
  16. 6056
    “…CONCLUSIONS: These findings demonstrate that berberine is an effective method of increasing the sensitization of GBM cells to TMZ treatment in a manner that is dependent upon the ERK1/2-mediated induction of autophagy, thus making berberine a potentially viable therapeutic agent for GBM treatment.…”
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    Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma
  17. 6057
    “…Overall, our study showed that a vegetarian diet modulates aging-associated circulating miRNAs in a sex-dependent manner of differential expression for certain miRNAs, which may be related in a beneficial manner to the healthspan. …”
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    Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone
  18. 6058
    “…Thus, we were able to develop a gender score in a retrospective manner from already collected data that characterized participants in addition to biological sex. …”
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    Gender score development in the Berlin Aging Study II: a retrospective approach
  19. 6059
    “…Our results demonstrated that gene therapy via the canalostomy approach, which has been considered to be one of the more feasible delivery methods for human inner ear gene therapy, preserved auditory and vestibular functions in a dose-dependent manner in a mouse model of JLNS2.…”
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    Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2
  20. 6060
    “…This application can be implemented to screen for differences in symptom severity in plant–pathogen interactions, and to visualize and quantify in a more sensitive and objective manner the intensity of the plant response on perception of a given immunological pattern. …”
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    Red light imaging for programmed cell death visualization and quantification in plant–pathogen interactions
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