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  1. 6081
    “…We show here that doxycycline treatment in mice drastically reduces the accumulation of proteins destined for degradation by the proteasome in a CNS region-specific manner. This effect is associated with the activation of the ERα axis of the mitochondrial unfolded protein response (UPR(mt)), in both males and females. …”
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    Doxycycline promotes proteasome fitness in the central nervous system
  2. 6082
    “…Utilizing pro‐Collagen I, as a shared ER‐phagy substrate, we observe that FAM134A acts in a LIR‐independent manner and compensates for the loss of FAM134B and FAM134C, respectively. …”
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    Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control
  3. 6083
    “…Gross observation and histological findings showed that oral AS treatment could significantly inhibit HS formation in a dose dependent manner. Semi‐quantification of scar elevation index at days 7, 15, 30, and 60, and quantitative polymerase chain reaction at days 30 and 60 also provided the evidences of reduced scar thickness and inhibited fibrotic gene expressions of collagens I, III, TGF‐β1, interleukins 1β, 6 and 8, and enhanced gene expression of SMAD 7 and PPAR‐γ with a dose‐dependent manner. …”
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    Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model
  4. 6084
    “…Low-dose WEE1i-ATRi synergistically decreases viability and colony formation and increases replication fork collapse and double-strand breaks (DSBs) in a CCNE1 copy number (CN)-dependent manner. Only upon CCNE1 induction does WEE1i perturb DNA synthesis at S-phase entry, and addition of ATRi increases DSBs during DNA synthesis. …”
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    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
  5. 6085
    “…Our findings reveal that while the Su(H)/Hairless co-repressor complex similarly binds SPS and CSL sites in an additive manner, the Notch activation complex binds SPSs, but not CSL sites, in a cooperative manner. …”
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    Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor
  6. 6086
    “…This result revealed that COH-203-induced apoptosis in HL-60 cells may occur via the mitochondrial pathway in a caspase-dependent manner.…”
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    G(2)/M cell cycle arrest and apoptosis induced by COH-203 in human promyelocytic leukemia HL-60 cells
  7. 6087
    “…FINDINGS/RESULTS: Our results indicated that galectin-9 can considerably reduce the cell growth and colony formation ability of both Jurkat and KE-37 cell lines in a concentration-dependent manner. Besides, galectin-9 induced apoptosis in a concentration-dependent manner in ALL cells by a mechanism associated with Bax/Bcl-2 expression and activation of the caspase-3 activation. …”
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    Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines via caspase-3 activation
  8. 6088
    “…Doing so in an unbiased, systematic, and replicable manner requires significant effort. RESULTS: The open-source test bench “VPMBench” automates the evaluation of variant prioritization methods. …”
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    VPMBench: a test bench for variant prioritization methods
  9. 6089
    “…This limits the utility of all manner of immunotherapeutic agents, which have revolutionized the treatment of a number of cancers in recent years, but have failed to show similar benefit in GBM therapy. …”
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    Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications
  10. 6090
    “…In vivo, upregulation of MCL-1 occurs in an FGF-dependent manner during skin repair, which regulates healing dynamics. …”
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    Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
  11. 6091
    “…StainNet can learn the color mapping relationship from a whole dataset and adjust the color value in a pixel-to-pixel manner. The pixel-to-pixel manner restricts the network size and avoids artifacts in the style transformation. …”
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    StainNet: A Fast and Robust Stain Normalization Network
  12. 6092
    “…Strikingly, growth of these bacteria appeared to be rescued by barley plants in a genotype- and dosage-independent manner. In parallel, we discovered that host recruitment cues can interfere with the impact of gramine application in a host genotype-dependent manner. …”
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    Applications of the indole-alkaloid gramine modulate the assembly of individual members of the barley rhizosphere microbiota
  13. 6093
    por Liu, Ao, Kage, Frieda, Higgs, Henry N.
    Publicado 2021
    “…Actin filaments are also important in Drp1 recruitment and activation. The manner in which Mff and actin work together in Drp1 activation is unknown. …”
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    Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division
  14. 6094
    “…The assembly of proteins in a programmable manner provides insight into the creation of novel functional nanomaterials for practical applications. …”
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    Dendrimer‐Like Supramolecular Assembly of Proteins with a Tunable Size and Valency Through Stepwise Iterative Growth
  15. 6095
    “…PERM (150 mg/kg and 300 mg/kg body weight/day, o.v.) increased lipoperoxidation and carbonylated proteins in a dose-dependent manner in the brain regions. The activities of antioxidant enzymes glutathione peroxidase, reductase, S-transferase, catalase, and superoxide dismutase showed an increase in all the different brain areas, with dose-dependent effects in the cerebellum. …”
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    Exposure to Sub-Lethal Doses of Permethrin Is Associated with Neurotoxicity: Changes in Bioenergetics, Redox Markers, Neuroinflammation and Morphology
  16. 6096
    “…Instead, the lack of DOCK11 in B cells resulted in the impaired secondary immune responses in a B cell-extrinsic manner, which was recovered by the adoptive transfer of cognate T cells. …”
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    The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells
  17. 6097
    “…SIBs repress the transcriptional function of WRKY75 and negatively regulate ABA-induced leaf senescence in a WRKY75-dependent manner. In contrast, WRKY75 positively modulates ABA-mediated leaf senescence in a GLK-dependent manner. …”
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    Arabidopsis SIGMA FACTOR BINDING PROTEIN1 (SIB1) and SIB2 inhibit WRKY75 function in abscisic acid-mediated leaf senescence and seed germination
  18. 6098
    “…BACKGROUND: Endosurgery is a surgical subspecialty that has been widely used in production animals, because it enables good visualization of abdominal organs and the diagnosis and treatment of several conditions in a minimally invasive manner, while preserving the animal’s well-being and causing a lower impact on animal production. …”
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    Percutaneous ruminostomy guided by rumenoscopy: study in an experimental model in bovine fetus
  19. 6099
    “…In the tumor microenvironment, macrophages display highly diverse phenotypes and may perform antitumorigenic or protumorigenic functions in a context-dependent manner. Recent studies have shown that macrophages can be engineered to transport drug nanoparticles (NPs) to tumor sites in a targeted manner, thereby exerting significant anticancer effects. …”
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    Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy
  20. 6100
    “…In addition, acetate enhances the killing activity of macrophages towards Streptococcus pneumoniae in an NO-dependent manner. Mechanistically, acetate improves IL-1β production by bacteria-conditioned macrophages and the latter acts in an autocrine manner to promote NO production. …”
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    Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis
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