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  1. 6201
    “…Infusion of d-serine with l-glutamate through the microdialysis probe significantly increased acetylcholine levels in the submandibular glands in an N-methyl-d-aspartate receptor glycine site antagonist-sensitive manner. ABSTRACT: d-serine has been observed in submandibular gland tissue in rats, but its functions remain to be clarified. …”
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    d-Serine Increases Release of Acetylcholine in Rat Submandibular Glands
  2. 6202
    “…In summary, we anticipate that investigating the TGFβ signalling family in a sex-specific manner will contribute to further understand the underlying processes leading to PAH and likely HHT.…”
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    Sex-biased TGFβ signalling in pulmonary arterial hypertension
  3. 6203
    “…We have observed that the AHR protein levels increase in the presence of chloroquine (CQ), an autophagy inhibitor, in a dose-dependent manner. Treatment with 6-aminonicotinamide (6-AN), a chaperone-mediated autophagy (CMA) activator, decreases AHR protein levels in a concentration-dependent and time-dependent manner. …”
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    Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells
  4. 6204
    “…PVP significantly increased solubility in a media-, grade- and concentration-dependent manner, with the biggest change in fasted media. HPMC and chitosan significantly reduced solubility in both fasted and fed states in a media-, grade- and concentration-dependent manner. …”
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    Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol
  5. 6205
    “…The ICA/TA-NDs showed prolonged release of ICA from the NDs for up to 28 days in a sustained manner. ICA/TA-NDs inhibited the mRNA levels of pro-inflammatory elements, including matrix metalloproteinases-3 (MMP-3), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and increased the mRNA levels of anti-inflammatory factors (i.e., IL-4 and IL-10) in LPS-activated RAW 264.7 macrophages. …”
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    Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats
  6. 6206
    “…These results indicated that the USM from both SKK and SMC can alleviate lipid accumulation in hepatocytes in an AMPK-dependent manner. Therefore, USM from wheat bran may be useful as a therapeutic intervention for treating metabolic-dysfunction-associated fatty liver disease.…”
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    Unsaponifiable Matter from Wheat Bran Cultivated in Korea Inhibits Hepatic Lipogenesis by Activating AMPK Pathway
  7. 6207
    “…We found that these E3 ligases interact with cyclin D1, regulate cyclin D1 ubiquitination and proteasome degradation in a phosphorylation-dependent manner. These E3 ligases also control cell cycle progression and cell proliferation through regulation of cyclin D1 protein stability. …”
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    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
  8. 6208
    por Byrne, Robert H
    Publicado 2002
    “…In the present work, the speciation of the elements in seawater is summarized in a manner that highlights the significance of pH variations. …”
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    Inorganic speciation of dissolved elements in seawater: the influence of pH on concentration ratios
  9. 6209
    “…To our knowledge this is the first report for inducible STAT1 expression in a time- and dose-dependent manner.…”
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    A time- and dose-dependent STAT1 expression system
  10. 6210
    por Newcomb, Eldon H.
    Publicado 1967
    “…Suggestions are made concerning the function of the tubular complex, role of the ameboid plastid forms, and manner of accumulation of the storage protein in the plastids.…”
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    FINE STRUCTURE OF PROTEIN-STORING PLASTIDS IN BEAN ROOT TIPS
  11. 6211
    Publicado 1984
    “…In some myotubes of 21-d embryos, myofibrils were in lateral registry as precisely as in adult myofibers but desmin was still widely distributed around Z line in an irregular manner. Nevertheless, in many other myotubes of prenatal or neonatal chicks, desmin became confined to the level of Z line in a manner similar to that seen in adult myofibers, thus essentially completing its redistribution to the confined state of adult myofibers in coincidence with the time of hatching. …”
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    Distributions of vimentin and desmin in developing chick myotubes in vivo. I. Immunofluorescence study
  12. 6212
    por Traub, Erich
    Publicado 1938
    “…A high degree of immunity, characterized by protective antibodies in the serum, was produced in some guinea pigs by prolonged treatment with large doses of homologous vaccine, while sera of guinea pigs vaccinated in the ordinary manner contained no detectable neutralizing antibodies. …”
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    IMMUNIZATION OF GUINEA PIGS AGAINST LYMPHOCYTIC CHORIOMENINGITIS WITH FORMOLIZED TISSUE VACCINES
  13. 6213
    Publicado 1995
    “…Thus peptide-specific alloreactivity is reflected in homologous CDR3 sequences in a manner similar to that described for T cells that recognize nominal peptide/self-MHC complexes. …”
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    In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex
  14. 6214
    “…Thus, V655A channels can interact with PSD-95 in a manner that leads to channel immobilization, but not clustering. …”
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    Distinct Structural Requirements for Clustering and Immobilization of K(+) Channels by PSD-95
  15. 6215
    Publicado 1981
    “…External TEA blocks the delayed K+ current reversibly in a dose-dependent manner. The experimental results are well fitted with a Michaelis-Menten expression, assuming a one-to-one reaction between TEA and a receptor site, with an apparent dissociation constant of 6.0 mM. …”
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    Effects of tetraethylammonium on potassium currents in a molluscan neurons
  16. 6216
    Publicado 1991
    “…(c) D600 was found to reduce the gating current in a voltage- and use-dependent manner. D600 was also found to induce "extra" charge movement at negative potentials. …”
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    Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes
  17. 6217
    por Gómez-Lagunas, Froylán
    Publicado 2001
    “…The Shaker B K(+) conductance (G(K)) collapses (in a reversible manner) if the membrane is depolarized and then repolarized in, 0 K(+), Na(+)-containing solutions (Gómez-Lagunas, F. 1997. …”
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    Na(+) Interaction with the Pore of Shaker B K(+) Channels: Zero and Low K(+) Conditions
  18. 6218
    “…Phosphorylation of estrogen receptor-α (ERα) at specific residues in transcription activation function 1 (AF-1) can stimulate ERα activity in a ligand-independent manner. This has led to the proposal that AF-1 phosphorylation and the consequent increase in ERα activity could contribute to resistance to endocrine therapies in breast cancer patients. …”
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    Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity
  19. 6219
    “…In the absence of axonin-1 these processes still extend but no longer in a parallel manner to each other or to the pial surface of the cerebellum. …”
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    Axonin-1/TAG-1 is required for pathfinding of granule cell axons in the developing cerebellum
  20. 6220
    “…OBJECTIVE: The glycoprofile of pathological prion protein (PrP(res)) is widely used as a diagnosis marker in Creutzfeldt-Jakob disease (CJD) and is thought to vary in a strain-specific manner. However, that the same glycoprofile of PrP(res) always accumulates in the whole brain of one individual has been questioned. …”
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    Regulating Factors of PrP(res) Glycosylation in Creutzfeldt-Jakob Disease - Implications for the Dissemination and the Diagnosis of Human Prion Strains
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