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  1. 6341
    “…Binocular OCT has the potential to perform a comprehensive eye examination in an automated manner, and thus improve the efficiency and quality of eye care. …”
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    Human Factor and Usability Testing of a Binocular Optical Coherence Tomography System
  2. 6342
    “…Mic27 acts in an antagonistic manner to Mic60 as it promotes oligomerization of the F(1)F(O)-ATP synthase and partially restores CJ formation in cells lacking Mic60. …”
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    Cristae architecture is determined by an interplay of the MICOS complex and the F(1)F(O) ATP synthase via Mic27 and Mic10
  3. 6343
    “…Results: We found that VP inhibited the proliferation of NB4 cells in a concentration and time-dependent manner. FCM analysis showed that VP induced apoptosis in a concentration dependent manner and that VP treatment led to cell cycle arrest at G0/G1 phase. …”
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    Verteporfin Inhibits Cell Proliferation and Induces Apoptosis in Human Leukemia NB4 Cells without Light Activation
  4. 6344
    “…Our findings show for the first time that EtOH can suppress DPC differentiation and mineralization in a mTOR-dependent manner, indicating that EtOH may be involved in negatively regulating the dental pulp repair.…”
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    Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling
  5. 6345
    por Thévenod, Frank, Lee, Wing-Kee
    Publicado 2015
    “…In a context-dependent manner, autophagy can either be protective and hence contribute to survival, or promote death by non-apoptotic or apoptotic pathways. …”
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    Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity
  6. 6346
    “…RESULTS: Curcumin suppressed the growth of EJ cells in a time and concentration dependent manner. Immunoblot showed that curcumin increased expression levels of c-myc and inhibited the activation of PI3K/Akt pathway in a time-dependent manner in EJ cells. …”
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    Curcumin Induces Apoptosis in EJ Bladder Cancer Cells via Modulating C-Myc and PI3K/Akt Signaling Pathway
  7. 6347
    “…STM induces oxidative stress by promoting reactive oxygen species (ROS) generation, depleting intracellular glutathione (GSH), and inhibiting thioredoxin reductase (TrxR) activity in a dose-dependent manner. Further mechanistic study demonstrated that STM induces apoptosis by modulation of Bax/Bcl-2 expressions, disruption of mitochondrial membrane potential, activation of caspase-3, and cleavage of PARP in a dose-dependent manner. …”
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    Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress
  8. 6348
    “…ConclusionCIK cells can reverse the drug resistance of A549/DDP in a time-dependent manner by reducing GST-π expression to increase the accumulation of DDP. …”
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    Cytokine-Induced Killer Cells Modulates Resistance to Cisplatin in the A549/DDP Cell Line
  9. 6349
    “…Emodin pretreatment significantly inhibited cell viability and survival colony formation but increased cell apoptosis of irradiation exposed MG63R cells in a concentration dependent manner. Moreover, emodin pretreatment inhibited Shh and Bcl2 expressions as well as Gli1 nuclear translocation but increased C-caspase-3 expression of irradiation exposed MG63R cells in a concentration dependent manner. …”
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    Emodin Impairs Radioresistance of Human Osteosarcoma Cells by Suppressing Sonic Hedgehog Signaling
  10. 6350
    “…RESULTS: Administration of IFN-γ (125–1000 U) increased K17 expression in a dose-dependent manner, and 250 U/ml IFN-γ significantly elevated K17 expression. …”
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    Effect of Calcipotriol on IFN-γ-Induced Keratin 17 Expression in Immortalized Human Epidermal Keratinocyte Cells
  11. 6351
    “…TDP43 upregulated miR-195 in an SNHG12-dependent manner. We further revealed that SNHG12 and miR-195 were in an RNA-induced silencing complex (RISC). …”
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    Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells
  12. 6352
    “…Aspirin reduced cell proliferation in a dose- and time-dependent manner, and altered the cell cycle phase distribution of KKU-214 cells by increasing the proportion of cells in the G0/G1 phase and reducing the proportion in the S and G2/M phases. …”
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    Inhibitory Effect of Aspirin on Cholangiocarcinoma Cells
  13. 6353
    “…OBJECTIVE: Surgical treatment options should be discussed in cases of frozen shoulder, which is usually treated in a conservative manner. In this study, we evaluated the efficacy of manipulation and arthroscopic release in cases of frozen shoulder which resisted conservative treatment. …”
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    MID-LONG TERM RESULTS OF MANIPULATION AND ARTHROSCOPIC RELEASE IN FROZEN SHOULDER
  14. 6354
    “…Gliptins also act in a glucose-independent manner and show vasoregenerative effects. We have shown that gliptins can remarkably accelerate vascular healing after vascular injury. …”
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    Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling
  15. 6355
    “…Overall, we demonstrate that UNC‐120/SRF controls the pace of muscle aging in a cell‐autonomous manner downstream of the insulin/IGF1 receptor.…”
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    UNC‐120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans
  16. 6356
    “…RESULTS: Added Sema3A inhibited the gene expression of inflammatory cytokines upregulated by CTS in a dose-dependent manner. Addition of Sema3A suppressed the activation of AKT, ERK, and NF-κB in a dose-dependent manner. …”
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    Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress
  17. 6357
    “…The Hedgehog and Notch signaling pathways act upstream of Ato and Tll to coordinate neural precursor specification in a timely manner. The correct spatial placement of the boundary between Ato and Tll in turn is required to control the precise number of primary and secondary PR precursors. …”
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    Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode
  18. 6358
    “…RESULTS: In EPM, embelin and karanjin decrease the transfer latency time in dose dependent manner and escape latency time in MWM method. A significant (P < 0.01) reduction in amnesia with an anti-Alzheimer’s effect found when results of isolated compounds were compared with standard and vehicle control. …”
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    Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata (L.) pierre and embelin from Embelia ribes Burm.f.
  19. 6359
    por Lv, Tao, Zhang, Wenjing, Han, Xiaoli
    Publicado 2018
    “…Treatment with zerumbone markedly induced apoptosis in hepatoma HepG2 cells and suppressed their invasion and metastasis in a dose-dependent manner. Further investigation revealed that treatment with zerumbone led to the dose-dependent induction of apoptosis and cell cycle arrest at G(2)/M phase in cancer cells. …”
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    Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway
  20. 6360
    “…RESULTS: HGF/Met signaling in endometrial cancer cell lines was stimulated in an autocrine manner, and was essential for cell survival. Inhibiting the HGF/Met signaling with foretinib induced p53-dependent apoptosis in endometrial cancer cell lines in vitro. …”
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    Foretinib (GSK1363089) induces p53-dependent apoptosis in endometrial cancer
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