“…Additionally, treatment with eugenol was found to reduce intracellular ROS levels while increasing cellular resistance to H(2)O(2), in a manner that was dependent on Nrf2. In conclusion, data from the present study suggest that eugenol is a protective agent against oxidative stress that exerts its effects through a Nrf2-dependent pathway, rendering eugenol and its derivatives to be promising candidates for the future development of antioxidants.…”
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“…The radiosensitivity and proliferation viability were increased in a received dose-dependent manner. Compared with parental cells, DNA double-strand breaks (DSBs) in cell lines that received higher-dose irradiation were significantly reduced. …”
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“…While isorhamnetin and chrysoeriol enhanced autophagy in an mTOR signaling-dependent manner, the actions of 2,2′,4′-trihydroxychalcone and zerumbone were independent of mTOR signaling. …”
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“…In conclusion, synovial fluid EV protein content is altered in a sex-specific manner with OA, explaining the increased prevalence and severity of OA in women.…”
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“…We have determined that stiffer skin tissue promotes the M1 macrophage subtype in a TRPV4-dependent manner; soft tissue does not. These findings were further validated by our in vitro results which showed that stiff matrix (50 kPa) alone increased expression of macrophage M1 markers in a TRPV4-dependent manner, and this response was further augmented by the addition of soluble factors; neither of which occurred with soft matrix (1 kPa). …”
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“…Then, we apply a scheduled sampling strategy that gradually transfers the training phase from a teacher-guided manner toward a more self-teaching manner. Finally, the ordinary logarithm probability loss function is leveraged by sentence length so that the inclination of generating short sentences is alleviated. …”
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“…We show that our state classification subdivides the known behaviors of the school in a meaningful manner, leading to a finer description of the system’s behavior.…”
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“…The production of large quantities of food must be conducted in a sustainable and responsible manner for nature and humans. In this sense, the appropriate application of agricultural pesticides plays a fundamental role since pesticide application in a qualified manner reduces human and environmental risks as well as the costs of food production. …”
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“…The method is based on the sequential steps: fragmentation of genomic DNAs, in vitro circularization, cleavage of target sequence in a CRISPR guide RNA-specific manner, high-throughput sequencing of the linearized DNA fragments in an unbiased manner, and identification of viral insertion sites via sequence analysis. …”
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“…Here, we used BioID2 in an innovative manner to identify and map domain-specific protein interactions for the human Ku70 protein. …”
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“…CM-SD increased DPPH radical scavenging activity in a dose-dependent manner, and up to 30 μg/mL of CM-SD did not express cytotoxicity in C2C12 cells. …”
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“…Aconitine had a significant pain relieving effect, which was similar to carbamazepine, in a dose-dependent manner. Aconitine may be an alternative pharmacological agent for the control of trigeminal neuralgia pain.…”
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“…The strategy introduced here for high-throughput screening of nanocoatings derived from combinations of coating precursors enables the discovery of new functional materials for various applications in science and technology in a cost-effective miniaturized manner.…”
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“…However, the exact role of these proteins is hard to define since in a context-dependent manner they can function as both oncogenes and tumor suppressors. …”
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“…RESULTS: Nar significantly alleviated nerve injury and decreased brain tissue water content and brain infraction volume in CI/R injury rats in a concentration-dependent manner. Reduction of TNF-α, IL-8 as well as MDA content and elevation of IL-10 as well as SOD activity were confirmed to be caused by Nar treatment in a concentration-dependent manner. …”
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“…Under diabetic conditions, recombinant VEGF (rVEGF) stimulated MC viability and BDNF production in a dose-dependent manner. rBDNF also supported MC viability in a dose-dependent manner. …”
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“…Neighboring synapses on a dendritic branch can interact in a synergistic, cooperative manner via nonlinear voltage-dependent mechanisms, such as NMDA receptors. …”
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“…In TRPV1-expressed proximal tubular cells LLC-PK(1), oxalate could induce cell damage in a time- and dose-dependent manner; this was associated with increased arachidonate 12-lipoxygenase (ALOX12) expression and synthesis of endovanilloid 12(S)-hydroxyeicosatetraenoic acid for TRPV1 activation. …”
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“…SB203580, a p38 inhibitor, reduced MAYV replication in a dose-dependent manner in both HDFs and HeLa cells. Additionally, SB203580 significantly decreased viral E1 protein expression. …”
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“…The smoke and dust emission real-time monitoring subsystems are employed for the monitoring in an accurate manner. A dual-channel TCP/IP protocol is used between remote and local controlling modules for secure and speedy communication of the system. …”
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