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  1. 6441
    “…Results showed that MDZ suppressed the amplitude of delayed-rectifier K(+) current (I(K(DR))) in concentration-, time-, and state-dependent manners. The IC(50) for MDZ-mediated reduction of I(K(DR)) density was 5.87 μM. …”
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    Midazolam’s Effects on Delayed-Rectifier K(+) Current and Intermediate-Conductance Ca(2+)-Activated K(+) Channel in Jurkat T-lymphocytes
  2. 6442
    “…The results showed that, asiaticoside stimulated the infected macrophages by stimulating increased production of TNF-α, IL-12 p40 and NO as well as increased expression of iNOS in a dose-dependent manner. In contrast the viability of the cells and the production of IL-1β and were reduced also in a dose-dependent manner when compared to untreated cells. …”
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    Immunomodulatory Effects of Asiaticoside Against Shigella flexneri-Infected Macrophages
  3. 6443
    “…In conclusion, the TCMacro method presented in this study provides a simple and robust method that is able to measure the relative tail coiling activities in zebrafish embryos in a high-throughput manner.…”
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    TCMacro: A Simple and Robust ImageJ-Based Method for Automated Measurement of Tail Coiling Activity in Zebrafish
  4. 6444
    “…Although GLO1 is ubiquitously expressed, protein levels and activities are regulated in a tissue-dependent manner. We provide a comparative analysis of GLO1 protein in different tissues. …”
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    The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy
  5. 6445
    “…We find that de novo mutations are generated in a replication-independent manner, typically on the genomic strand, and highly dependent on mutagenic mechanisms specific to the host cellular environment. …”
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    Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process
  6. 6446
    “…We report the bottom-up synthesis of a hierarchical metal-phenolic mesocrystal where self-assembly proceeds on different length scales in a spatiotemporally controlled manner. Phenolic-based coordination complexes organize into supramolecular threads that assemble into tertiary nanoscale filaments, lastly packing into quaternary mesocrystals. …”
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    Superstructured mesocrystals through multiple inherent molecular interactions for highly reversible sodium ion batteries
  7. 6447
    “…Results indicate that cefazolin, ceftazidime, polymyxin B, and vancomycin activate the Rcs system to varying degrees in an RcsB-dependent manner, whereas ciprofloxacin and tobramycin activated the promoter fusions, but in an Rcs-independent manner. …”
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    Antibiotics Used in Empiric Treatment of Ocular Infections Trigger the Bacterial Rcs Stress Response System Independent of Antibiotic Susceptibility
  8. 6448
    “…All preanalytical and analytical steps were carried out in a highly standardized manner at a single certified testing center. SARS-CoV-2 specific PCR analysis revealed in these samples a positivity rate of 0.43%. …”
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    Evolution of SARS-CoV-2 Key Mutations in Vienna Detected by Large Scale Screening Program
  9. 6449
    por Gaur, Aaditya Vikram, Agarwal, Rakhi
    Publicado 2021
    “…Feeding behavior was depleted due to inhibition in pharyngeal pumping varying from 11.05% - 45.67% in a time-dependent manner. Results of locomotion assay also show time-varying increase in reversals (4.9%–34.03%) and omega bends (26.23%–62.17%) with reduction in turn counts (29.07%- 42.2%) and peristaltic speed (31.38%–42.22%) amongst exposed groups as to control. …”
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    Risperidone induced alterations in feeding and locomotion behavior of Caenorhabditis elegans
  10. 6450
    “…Moreover, robots have to move in a human-aware manner—that is, robots have to navigate in such a way that people feel safe and comfortable. …”
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    Social Robot Navigation Tasks: Combining Machine Learning Techniques and Social Force Model
  11. 6451
    “…Secondly, we propose a diffusion control stratedy to the update UAV-UAV force, which optimizes FV in a distributed manner. In this diffusion strategy, each UAV optimizes the local parameter by exchanging information with neighbor UAVs, which achieve global load balancing in a distributed manner. …”
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    Joint UAVs’ Load Balancing and UEs’ Data Rate Fairness Optimization by Diffusion UAV Deployment Algorithm in Multi-UAV Networks
  12. 6452
    “…After PMA treatment, M. cochinchinensis extracts were added to cultured media in a dose-dependent manner. Melanin contents and MTS were used to determine the amount of melanin in live cells. …”
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    Preventive Effect of M. cochinchinensis on Melanogenesis via Tyrosinase Activity Inhibition and p-PKC Signaling in Melan-A Cell
  13. 6453
    “…Nisin-biogel sub-MICs decreased bacterial growth in a strain- and dose-dependent manner, decreased agrI, atl and clfA expression, and increased spA, coa, icaA and icaD expression. …”
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    Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in Staphylococcus aureus Isolates from Diabetic Foot Infections
  14. 6454
    “…In contrast, low concentrations of PBCA enhanced bulk autophagic cargo flux in a Vps34-, ULK1/2- and ATG13-dependent manner, yet interestingly, without an accompanying increase in LC3 lipidation or flux. …”
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    Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
  15. 6455
    “…In the present study, GCN2 was found to interact with NRF2 and decrease NRF2 expression in a KEAP1-dependent manner. Activation of GCN2 by halofuginone treatment or leucine deprivation decreased NRF2 expression in hepatocytes by increasing GSK-3β activity. …”
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    Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation
  16. 6456
    “…We found that WUD inhibited the proliferation of HT-29 and HCT116 cells in a time- and dose-dependent manner and induced intracellular ROS generation. The inhibitory effect of WUD on the proliferation of HT-29 and HCT116 cells could be attenuated by NAC (a ROS scavenger) in a dose-dependent manner. …”
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    Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation
  17. 6457
    “…In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. …”
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    Drug release study of the chitosan-based nanoparticles
  18. 6458
    por Xiao, Xinyi, Xiao, Hanbin
    Publicado 2021
    “…However, the current robotic additive process heavily relies on manual geometric reasoning that identifies additive features, related building orientations, tool approach direction, trajectory generation, and sequencing all features in a non-collision manner. In addition, multi-directional material accumulation cannot ensure the nozzle always stays above the building geometry. …”
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    Autonomous Robotic Feature-Based Freeform Fabrication Approach
  19. 6459
    por Şimşek, Hakan, Yangın, Elifnaz
    Publicado 2022
    “…Therefore, the aim of this study is to construct a support system based on fuzzy logic for experts to help detect of COVID-19 infection risk in a timely and accurate manner and to get a numerical output on symptoms of the virus from every person. …”
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    An alternative approach to determination of Covid-19 personal risk index by using fuzzy logic
  20. 6460
    “…High-dose nitrite exposure caused infertility in a time-dependent manner, and two-round exposure induced higher infertility than that one-round exposure (p<0.01). …”
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    Nitrite exposure may induce infertility in mice
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