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  1. 6501
    “…Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. …”
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    Population Screening for Colorectal Cancer Means Getting FIT: The Past, Present, and Future of Colorectal Cancer Screening Using the Fecal Immunochemical Test for Hemoglobin (FIT)
  2. 6502
    “…The differential reactivity is exploited to introduce two orthogonal reactive handles onto the surface of a double cysteine mutant of superfolder green fluorescent protein in a regioselective manner. Subsequent elaboration with commonly used thiol and alkyne containing reagents affects site-selective protein dual labelling.…”
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    A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification
  3. 6503
    “…The biosensor is operated in a fully automated manner without attenuating the sensor sensitivity. …”
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    Biosensors: Label‐Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes (Adv. Sci. 5/2017)
  4. 6504
    “…Non‐oxidative, regioselective, and convergent access to densely functionalized oxazoles is realized in a functional‐group tolerant manner using alkynyl thioethers. Sulfur‐terminated alkynes provide access to reactivity previously requiring strong donor‐substituted alkynes such as ynamides. …”
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    Alkynyl Thioethers in Gold‐Catalyzed Annulations To Form Oxazoles
  5. 6505
    “…Echocardiography is helpful to diagnose myxoma in a timely manner and allows urgent surgical resection of the myxoma. …”
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    Giant left atrial myxoma causing acute ischemic stroke in a child
  6. 6506
    “…This article details the appropriate manner in which to tie this knot.…”
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    The West Point Knot: A Sliding-Locking Arthroscopic Knot
  7. 6507
    “…If not managed in a timely manner, it can lead to permanent vision loss. Rivaroxaban is a directly acting oral anticoagulant (DOAC) that inhibits factor Xa and is widely used for stroke prevention in patients with non-valvular atrial fibrillation (AFib).…”
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    Sudden Loss of Vision: An Insight into Rivaroxaban
  8. 6508
    “…The elimination of hydroxyl phosphonates yielded the desired tetrasubstituted olefins in a stereoselective manner. Thus, homofarnesenes of fire ant trail pheromones have been synthesized efficiently using this strategy.…”
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    Stereoselective Synthesis of Homofarnesenes: Establishment of an Efficient Method for the Stereoselective Preparation of Acyclic Tetrasubstituted Olefins
  9. 6509
    “…HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface.…”
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    Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
  10. 6510
    “…[Image: see text] A novel four-step bidirectional strategy has been used to synthesize the IJK fragment of the marine polyether natural product CTX3C from a simple monocyclic precursor in a concise and efficient manner. The four-step bidirectional sequence involves ring-closing metathesis, alcohol oxidation, enol carbonate formation, and palladium-mediated Tsuji–Trost allylation.…”
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    Bidirectional Synthesis of the IJK Fragment of Ciguatoxin CTX3C by Sequential Double Ring-Closing Metathesis and Tsuji–Trost Allylation
  11. 6511
    por Bruhn, Hans K.
    Publicado 2020
    “…Suggestions are offered for maintaining contact with patients, managing their expectations for care, and rendering care in a prudent and timely manner. By following these steps, professional liability risk (medical malpractice) can be mitigated.…”
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    Telemedicine: dos and don'ts to mitigate liability risk
  12. 6512
    “…Although every conference will have some local differences, there are common approaches to presenting your research in the best manner. This will differ depending on whether it is an oral or a poster presentation. …”
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    Conference presentations: A research primer for low- and middle-income countries
  13. 6513
    “…A wide range of 3-substituted benzothiophenes were synthesized from easily available o-silylaryl triflates and alkynyl sulfides in a one-step intermolecular manner. The synthesis of diverse multisubstituted benzothiophene derivatives involving a pentacyclic compound was achieved by virtue of the good functional group tolerance and versatile C2 functionalizations.…”
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    One-step synthesis of benzo[b]thiophenes by aryne reaction with alkynyl sulfides
  14. 6514
    “…The reactions proceed in a highly diastereoselective manner and afford 5-vinyl-1-pyrroline derivatives in 60–88% yields.…”
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    Tin(iv) chloride mediated (3 + 2) annulation of trans-2-aroyl-3-styrylcyclopropane-1,1-dicarboxylates with nitriles: diastereoselective access to 5-vinyl-1-pyrroline derivatives
  15. 6515
    “…An automated synthesis protocol is developed for the synthesis of block copolymers in a multi-step approach in a fully automated manner. For this purpose, an automated dialysis setup is combined with robot-based synthesis protocols. …”
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    Fully Automated Multi-Step Synthesis of Block Copolymers
  16. 6516
    “…The goal of these articles is to disseminate updated recommendations, in a timely manner, to better inform health practitioners and the public on the best available cancer care options.…”
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    Management and Care of Patients With Invasive Cervical Cancer: ASCO Resource-Stratified Guideline Rapid Recommendation Update
  17. 6517
    “…Vilsmeier–Haack formylation of ReO and Au meso-triarylcorroles over 16–18 hours affords moderate to good yields (47–65%) of the ReO-3-formyl and Au-3,17-diformyl derivatives in a highly regioselective manner. Formylation was found to effect substantial upshifts for redox potentials (especially the reduction potentials) as well as significant to dramatic redshifts for both the Soret and Q bands.…”
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    Regioselective formylation of rhenium-oxo and gold corroles: substituent effects on optical spectra and redox potentials
  18. 6518
    “…The reaction proceeded in a diastereoselective manner to afford four chiral stereocenters. The method also has advantages of wide substrate scope, readily available starting materials and operational simplicity through one pot reaction.…”
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    Tosylhydrazine-promoted self-conjugate reduction–Michael/aldol reaction of 3-phenacylideneoxindoles towards dispirocyclopentanebisoxindole derivatives
  19. 6519
    “…Through transition metal-catalyzed or transition metal-free transformations, diverse polycycles are prepared in an efficient, rapid, and step-economical manner.…”
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    Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles
  20. 6520
    “…By judiciously manipulating the structural variations of 1-alkenylbenzotriazoles, two characteristic polycyclic skeletons associated with monoterpene indole alkaloids were constructed through a diverted and controllable manner. The present work not only enriches the photochemistry of 1-alkenylbenzotriazoles, but also offers a unified approach to access skeletally diverse indole alkaloid scaffolds.…”
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    Natural Product-Oriented Photo-Induced Denitrogenative Annulations of 1-Alkenylbenzotriazoles
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