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  1. 6541
    “…[Image: see text] We report an enantioselective synthesis of cyclic ketones with full substitutions at the α-positions in a highly diastereoselective manner. Our method is achieved by subjecting substrate motifs in 2-allyloxyenones to chiral organomagnesium reagents, which trigger the Claisen rearrangement upon direct 1,2-carbonyl addition. …”
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    Directing the Stereoselectivity of the Claisen Rearrangement to Form Cyclic Ketones with Full Substitution at the α-Positions
  2. 6542
    por Stearn, Allen E.
    Publicado 1926
    “…Other pairs of ampholytes are shown to act in an analogous manner.…”
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    AMPHOTERIC BEHAVIOR OF COMPLEX SYSTEMS : II. TITRATION OF SULFANILIC ACID-GLYCINE MIXTURES.
  3. 6543
    “…Aortic dissection is an uncommon but potentially lethal illness that can present in an occult manner making the initial diagnosis difficult. Aggressive medical management is mandatory, as well as urgent diagnostic testing and cardiothoracic consultation.…”
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    Dissection of the ascending thoracic aorta as a complication of percutaneous coronary intervention
  4. 6544
    “…Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner.…”
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    Regulation of cellular proliferation, differentiation and cell death by activated Raf
  5. 6545
    “…A critical step in gene therapy is the efficient transfer of genes in a cell-type and tissue specific manner. To better understand the mechanism of AAV6 transduction we used CGA combined with pathway visualization software to identify a positive correlation between AAV6 transduction and EGFR expression. …”
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    Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
  6. 6546
    por Ma, De-Yun, Deng, Guo-Hua, Song, Wen-Dong
    Publicado 2007
    “…The carboxyl­ate group binds in a monodentate manner so that the geometry is best described as tetra­hedral. …”
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    Diaqua­bis(4-methyl­benzoato-κO)zinc(II)
  7. 6547
    “…The compounds were prepared in a brief and efficient manner from thiophene-2-carbaldehyde using a ring-closing metathesis with Grubbs I or Grubbs II catalyst as the key step. …”
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    Synthesis by Ring-Closing Metathesis and Cytotoxic Evaluation of Novel Thienylmacrolactones
  8. 6548
    por Fauci, Anthony S.
    Publicado 2012
    “…The potential benefits and risks of these experiments must be discussed and understood by multiple stakeholders, including the general public, and all decisions regarding such research must be made in a transparent manner.…”
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    Research on Highly Pathogenic H5N1 Influenza Virus: The Way Forward
  9. 6549
    “…Glenoid hypoplasia is a relatively rare alteration that in most cases involves the pectoral girdle in a bilateral and symmetrical manner. In general, glenoid hypoplasia is associated with skeletal changes such as hypoplasia of the humeral head or changes in the morphology of the acromion and of the coracoid. …”
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    Unilateral Glenoid Hypoplasia: A Case Report and Review of the Literature
  10. 6550
    por Tang, Melissa LF, Gasser, Stephan
    Publicado 2013
    “…We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhanced immune recognition by stimulating the expression of the DNAM-1 ligand CD155.…”
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    ATM activation mediates anticancer immunosurveillance by natural killer and T cells
  11. 6551
    “…Occupational therapy applies in a targeted manner activities as therapeutic measure. Aim is a high quality of life in everyday life – also without drugs. …”
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    The effectiveness of occupational therapy for persons with moderate and severe dementia
  12. 6552
    por Frendéus, Björn
    Publicado 2013
    “…We have recently provided in vivo proof-of-concept for a “function-first” target and drug discovery platform in which antibodies against a multitude of tumor-associated antigens are screened for biological effects in a target-unbiased manner.…”
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    Function-first antibody discovery: Embracing the unpredictable biology of antibodies
  13. 6553
    “…Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain to be elucidated. …”
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    Midline crossing and Slit responsiveness of commissural axons require USP33
  14. 6554
    por Bhaumik, Soumyadeep
    Publicado 2012
    “…The article briefly discusses the current status of polio control across the globe, and various challenges associated with it in a nation-wise manner.…”
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    Polio eradication: Current status and challenges
  15. 6555
    por Dumit, Joseph
    Publicado 2014
    “…Examples from Lettvin et. al. are used to demonstrate that one can experimentally play with neurons and generate surprising results. In this manner, brains are not confused with persons, rather, persons are understood to do things with their brains.…”
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    Plastic neuroscience: studying what the brain cares about
  16. 6556
    “…Approaching the application in a timely and structured manner, seeking advice from current and previous award-holders and members of review panels, and obtaining preliminary data are key ingredients to success.…”
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    Strategies to secure surgical research funding: fellowships and grants
  17. 6557
    “…This novel protocol is relatively easy to implement and could contribute to overcome the challenge of obtaining various shaped iron oxides in economical and sustainable manner.…”
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    Facile and Sustainable Synthesis of Shaped Iron Oxide Nanoparticles: Effect of Iron Precursor Salts on the Shapes of Iron Oxides
  18. 6558
    “…We highlight the ability to avoid the need for sclerostomies by preventing intraoperative shallowing of the anterior chamber and the use of tight scleral sutures which should be adjusted postsurgery to gradually reach the target intraocular pressure in a step-wise manner.…”
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    Surgical management of glaucoma secondary to idiopathic elevated episcleral venous pressure
  19. 6559
    por Rau, Thomas, Kamaya, Aya
    Publicado 2015
    “…The patient subsequently underwent autologous followed by nonmyeloablative allogenic bone marrow transplant and relapsed after six years in an unusual manner with extensive extramedullary disease with bilateral perirenal involvement. …”
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    Relapsed Extramedullary Multiple Myeloma Presenting as Bilateral Solid Perirenal Masses
  20. 6560
    por Lush, Denzil
    Publicado 1993
    “…This paper briefly examines the underlying philosophy of advance directives, and the manner in which they have evolved in the United States. …”
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    Advance Directives and Living Wills
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