Mostrando 641 - 660 Resultados de 103,171 Para Buscar '"Mannerism"', tiempo de consulta: 0.44s Limitar resultados
  1. 641
  2. 642
    “…Our results suggest MPA suppresses amyloid-beta degradation in an MMP-9-dependent manner, in vitro, and potentially compromises the clearance of amyloid-beta in vivo.…”
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    “…Conclusion: Fusobacterium increased significantly in IBS-D patients, and F. nucleatum was involved in the pathogenesis of IBS by causing microbial dysbiosis and exacerbating visceral hypersensitivity in a colonization-independent manner. Meanwhile, F. nucleatum was found to induce an increase in specific secretory IgA through FomA.…”
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    “…Collectively, our data provide cogent proofs that STRN translocates to the cytosol where it undergoes proteolytic cleavage in a caspase 3-dependent manner during apoptosis. Thus, this study projects the cleavage of STRN as a novel marker for apoptosis to serve pharmacological strategies targeting this particular form of cell death.…”
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  11. 651
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    “…We here demonstrate how HFD and estrogens modulate the colon microenvironment in a sex- and ER-specific manner.…”
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  15. 655
    “…Using established cellular HE models, we show that mitochondria rapidly undergo fragmentation in a reversible manner upon hyperammonemia. Further, in our analyses, within a timescale of minutes, mitochondrial respiration and glycolysis were hampered, which occurred in a pH-independent manner. …”
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    “…The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca(2+) signaling axis, providing clear arguments for a functional relationship with metabolic adaptations for cell survival. …”
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  19. 659
  20. 660
    “…To dissect the direct effect of PARP1 on mtDNA from the secondary perturbation of metabolism, we report here biochemical studies that recapitulated Pol γ PARylation observed in cells and showed that PARP1 regulates Pol γ activity during DNA repair in a metabolic cofactor NAD(+) (nicotinamide adenosine dinucleotide)-dependent manner. In the absence of NAD(+), PARP1 completely inhibits Pol γ, while increasing NAD(+) levels to a physiological concentration that enables Pol γ to resume maximum repair activity. …”
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