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  1. 6601
    “…This case report presents the MRI findings of aplasia of the anterior cruciate ligament with associated hypoplasia of the posterior cruciate ligament (Manner type 2). Radiographically the presence of a shallow femoral notch and hypoplastic tibial spines (the so-called “dromedar” sign) can aid in the diagnosis. …”
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    Absent Anterior Cruciate Ligament
  2. 6602
    por Infante, Juan C.
    Publicado 2018
    “…This perspective examines both affinity-based and nanoparticle-based strategies for delivery of neurotrophic factors (NFs) to the spinal cord in an effective, safe, and tunable manner.…”
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    Nanoparticle-Based Systems for Delivery of Protein Therapeutics to the Spinal Cord
  3. 6603
    “…As reported previously, our mechanistic studies including oxygen-18 labelling experiments indicate that the rearrangement of the alkoxycarbonyloxy group proceeds in [1,3]-manner. In this article, we discuss the overall picture of the cobalt-catalysed [1,3]-rearrangement reaction including details of the reaction conditions and substrate scope.…”
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    Cationic cobalt-catalyzed [1,3]-rearrangement of N-alkoxycarbonyloxyanilines
  4. 6604
    “…We report the unexpected formation of a 1-azadiene dimer from 4,6-diphenyl-3,6-dihydro-2H-1,3-thiazine-2-thiones under prolonged microwave irradiation. In this manner, thiazine-2-thiones act as “masked” 1-azadiene equivalents, which makes them useful synthetic tools to access complex heterocyclic frameworks. …”
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    Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions
  5. 6605
    “…They allow users to edit, convert, and validate PDB files, from the command-line, in a simple but efficient manner. The pdb-tools are implemented in Python, without any external dependencies, and are freely available under the open-source Apache License at https://github.com/haddocking/pdb-tools/ and on PyPI.…”
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    pdb-tools: a swiss army knife for molecular structures
  6. 6606
    “…We propose a strategy and present a simple tool to facilitate scientific data reproducibility by making available, in a distributed manner, all data and procedures presented in scientific papers, together with metadata to render them searchable and discoverable. …”
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    Qresp, a tool for curating, discovering and exploring reproducible scientific papers
  7. 6607
    “…In article number 1801380, Jiyun Kim, Sunghoon Kwon, and co‐workers report a method to generate a large‐scale heterogeneous drug‐releasing‐microarray via a “pipetting‐free” manner by self‐assembly of encoded drug‐laden microparticles on the array of microwells. …”
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    High‐Throughput Screening: One‐Step Generation of a Drug‐Releasing Hydrogel Microarray‐On‐A‐Chip for Large‐Scale Sequential Drug Combination Screening (Adv. Sci. 3/2019)
  8. 6608
    “…We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function.…”
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    Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function
  9. 6609
    “…This method allowed carbon-carbon bond formation of “non-activated” aziridine via aziridinium ion ring-opening in regio- and stereo-selective manner for the first time. This newly developed reaction was applied for an efficient synthesis of alkaloid with the representative example of conine and epiquinamide.…”
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    Alkylative Ring-Opening of Bicyclic Aziridinium Ion and Its Application for Alkaloid Synthesis
  10. 6610
    “…Herein, we described an electrochemical strategy to perform the bioconjugation of tyrosine residues with phenothiazine derivatives in a rapid and simple manner. In this electrochemical system, various polypeptides and proteins were successfully labelled with excellent site- and chemo-selectivity, and metals, oxidants or additives were also avoided.…”
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    Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules
  11. 6611
    “…Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.…”
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    Butler enables rapid cloud-based analysis of thousands of human genomes
  12. 6612
    “…Over the past decade, mass spectrometry has become the basis for proteomics, especially for protein identification, performed in a high-throughput manner. This development was also very fruitful for exploring the complex systems associated with protease functions, as briefly reviewed here. …”
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    Mass spectrometry for monitoring protease reactions
  13. 6613
    por Arul, G. Suren
    Publicado 2016
    “…Most childhood tumors will first present to a physician; some tumors will present in an atypical manner and may mimic a surgical condition. The diagnosis may be missed if the surgeon is not aware of the possibility of cancer. …”
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    Surgical Complications of Childhood Tumors
  14. 6614
    por Paterson, Grace
    Publicado 2020
    “…The account is used to examine two important subclasses of anonymized speech: speech using pseudonyms, and speech anonymized in a specifically communicative manner. Several pragmatic and ethical issues with anonymized speech are considered.…”
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    Sincerely, Anonymous
  15. 6615
    “…Key is the use of Pd catalysis, which allows the addition of aromatic and aliphatic thiocyanates in an intra- and intermolecular manner. Substrates with several alkyne units underwent further carbopalladation steps after the initial thiopalladation step, thus generating in a cascade-like fashion an oligoene unit with sulphur at one terminus and the cyano group at the other.…”
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    From 1,2-difunctionalisation to cyanide-transfer cascades – Pd-catalysed cyanosulfenylation of internal (oligo)alkynes
  16. 6616
    “…Unactivated secondary and tertiary C–H bonds at β, γ, and δ positions can be functionalized in a predictable manner.…”
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    Photo-induced copper-catalyzed alkynylation and amination of remote unactivated C(sp(3))-H bonds
  17. 6617
    por Dinnebier, Robert, Scardi, Paolo
    Publicado 2021
    “…Common distribution functions, the concept of convolution in real and Fourier space, instrumental aberrations, and microstructural effects are visualized in an interactive manner and explained in detail. This paper is the first part of a series dealing with the mathematical description of powder diffraction patterns for teaching and education purposes.…”
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    X-ray powder diffraction in education. Part I. Bragg peak profiles
  18. 6618
    “…This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.…”
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    SO(2)F(2)-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)
  19. 6619
    “…The method was also applied to Suzuki–Miyaura cross-coupling reaction in a one-pot two-step sequential manner, providing a facile and convenient access to the direct synthesis of biaryl compounds from aryl chlorides.…”
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    Room-temperature borylation and one-pot two-step borylation/Suzuki–Miyaura cross-coupling reaction of aryl chlorides
  20. 6620
    por Chen, Xu, Marek, Ilan
    Publicado 2022
    “…The substitution occurs at the most substituted quaternary carbon center in a stereoinvertive manner, which may be attributed to the existence of a bicyclobutonium species.…”
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    Stereoinvertive Nucleophilic Substitution at Quaternary Carbon Stereocenters of Cyclopropyl Ketones and Ethers
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