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  1. 6741
    “…This is in part due to a lack of drug discovery platforms capable of assessing complex human neuromuscular disease phenotypes in a scalable manner. A major obstacle has been generating scaffolds to stabilise mature contractile myofibers in a multi-well assay format amenable to high content image (HCI) analysis. …”
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    A scalable human iPSC-based neuromuscular disease model on suspended biobased elastomer nanofiber scaffolds
  2. 6742
    “…These data point to additional therapeutic approaches to combat C. difficile in a butyrate-directed manner.…”
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    Butyrate enhances Clostridioides difficile sporulation in vitro
  3. 6743
    “…Collectively, our data demonstrate that circ-β-TrCP-encoded β-TrCP protein isoform drives HER2-targeted therapy resistance in a NRF2-dependent manner, which provides potential therapeutic targets for overcoming trastuzumab resistance.…”
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    The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer
  4. 6744
    “…The fertilization rates decreased in a concentration-dependent manner, with significant reduction following treatment with TBT at 0.05 ppb. …”
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    Effects of Tributyltin-Contaminated Aquatic Environments and Remediated Water on Early Development of Sea Urchin (Hemisentrotus pulcherrimus)
  5. 6745
    “…B. glumae secretes oxalic acid as a “common good” in a QS‐dependent manner to combat toxic alkalinization of the growth medium during the stationary phase. …”
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    A membrane protein of the rice pathogen Burkholderia glumae required for oxalic acid secretion and quorum sensing
  6. 6746
    “…Here, we propose a microfluidic channel design for the size-based hydrodynamic enrichment of CTCs from blood in an epitope-independent and high-throughput manner. The microfluidic channel comprises a spiral-shaped part followed by a widening part, incorporating successive streamlined pillars, that improves the enrichment efficiency. …”
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    Analytical Validation of a Spiral Microfluidic Chip with Hydrofoil-Shaped Pillars for the Enrichment of Circulating Tumor Cells
  7. 6747
    “…They are often studied together and typically treated in the same manner using extension splints. However, evidence clearly shows that these are different injuries which present in the same manner. …”
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    Outcome Differences between Conservatively Treated Acute Bony and Tendinous Mallet Fingers
  8. 6748
    “…The models have revealed the manner in which the 2-epimerase anchors its UDP-sugar substrate as well as its UDP-sugar product into the active site. …”
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    Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis
  9. 6749
    “…The ZMYM2-TRIM28 complex forms in a SUMO-dependent manner and is associated with repressive chromatin. …”
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    ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes
  10. 6750
    “…The purified KIF1C IDR domain undergoes LLPS in vitro at near-endogenous nM concentrations in a salt-dependent manner. Deletion of the IDR abolished the ability of KIF1C to undergo LLPS and disrupted the distribution of mRNA cargoes to the cell periphery. …”
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    KIF1C, an RNA transporting kinesin-3, undergoes liquid-liquid phase separation through its C-terminal disordered domain
  11. 6751
    por Cho, Ye-Jin, Park, So-Hyun, Ryu, Kwon-Yul
    Publicado 2023
    “…Thus, it appears that mild oxidative stress, occurring in an Nrf2-independent manner, is required for the downregulation of Lcn2 expression. …”
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    Mild Oxidative Stress Induced by Sodium Arsenite Reduces Lipocalin-2 Expression Levels in Cortical Glial Cells
  12. 6752
    “…BACKGROUND: Early during COVID-19, British Columbia coordinated collaboration between academic researchers, public healthcare systems, and private sector partners to focus research resources on knowledge gaps in a timely manner, avoid duplication, and identify overlooked aspects. …”
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    COVID-19 and British Columbia’s volunteer search and rescue workers: risk recognition and risk mitigation
  13. 6753
    “…CONCLUSION: Suspicious deaths of married women brought for medico-legal autopsy must be dealt with due to precaution to determine the cause and manner of death. One must be vigilant that the suspicious death of a married female may be associated with dowry in the Indian scenario.…”
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    Pattern of suspicious deaths of married females brought for medico-legal autopsy at teaching institute of India
  14. 6754
    “…We hypothesized that F. graminearum treatment shifts the cultured transmitting silk microbiome (TSM) compared to healthy silks in a distance-dependent manner. Another objective of the study was to culture microbes for future application. …”
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    The Cultured Microbiome of Pollinated Maize Silks Shifts after Infection with Fusarium graminearum and Varies by Distance from the Site of Pathogen Inoculation
  15. 6755
    por Mak, Johnson
    Publicado 2005
    “…As plants and invertebrates lack the protein-based adaptive immunity that are found in jawed vertebrates, the ability of RNA silencing to shut down gene expression in a sequence-specific manner offers an explanation of how these organisms counteract pathogen invasions into host cells. …”
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    RNA interference: more than a research tool in the vertebrates' adaptive immunity
  16. 6756
    “…PD98059 (an inhibitor of Erk1/2 pathway) suppressed IL-1-induced COX-2 expression and PGE(2) production in a dose-dependent manner, and seemed to have an inhibitory effect on COX-2 activity. …”
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    Inhibitors of Mitogen-Activated Protein Kinases Downregulate COX-2 Expression in Human Chondrocytes
  17. 6757
    “…Consistent with our observation in L1s, DAF-16 also translocates to the cytoplasm in old adult worms in an age-1-dependent manner. CONCLUSION: DAF-16 is activated in the starved L1 diapause. …”
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    Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm
  18. 6758
    “…DDT, dieldrin, and toxaphene inhibited GJIC in a dose-responsive manner after 90 min treatments. Dieldrin suppressed GJIC within 30 min with no recovery after 24 hr. …”
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    Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures.
  19. 6759
    por Edgar, Alasdair J
    Publicado 2003
    “…BACKGROUND: Overlapping sense/antisense genes orientated in a tail-to-tail manner, often involving only the 3'UTRs, form the majority of gene pairs in mammalian genomes and can lead to the formation of double-stranded RNA that triggers the destruction of homologous mRNAs. …”
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    The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12
  20. 6760
    “…RESULTS: We propose a novel method to compare the protein structures in an accurate and efficient manner. Such a method can be used to not only reveal divergent evolution, but also identify circular permutations and further detect active-sites. …”
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    Revealing divergent evolution, identifying circular permutations and detecting active-sites by protein structure comparison
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