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  1. 6781
    “…RESULTS: Retinoic acid markedly inhibited proliferation of two cell lines (Capan-2 and Hs766T) in a concentration and time-dependent manner. Retinoic acid increased TGF-β2 mRNA content and secretion of the active and latent forms of TGF-β2 (measured by ELISA and bioassay). …”
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    On the role of transforming growth factor-β in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells
  2. 6782
    “…We show that the polyamines (spermine, spermidine, and putrescine) inhibit the MIC current, also in a voltage-independent manner, with a potency that parallels the number of charges. …”
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    Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels
  3. 6783
    “…Thus, M1 manipulates the host CD8(+) T cell response in a manner that facilitates latent infection in an immunocompetent setting, but promotes disease during a dysregulated immune response. …”
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    A gammaherpesvirus-secreted activator of Vβ4(+) CD8(+) T cells regulates chronic infection and immunopathology
  4. 6784
    “…In addition, we applied the idFBA framework in a similar manner to a representative module of the single-cell eukaryotic organism Saccharomyces cerevisiae. …”
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    Dynamic Analysis of Integrated Signaling, Metabolic, and Regulatory Networks
  5. 6785
    por Schmidt, Ruth, Baumann, Otto, Walz, Bernd
    Publicado 2008
    “…Intraluminal Ca(2+ )measurements in the ER of β-escin-permeabilized glands with mag-fura-2 revealed that cAMP augmented InsP(3)-induced Ca(2+ )release in a concentration-dependent manner. This indicated that cAMP sensitized the InsP(3 )receptor Ca(2+ )channel for InsP(3). …”
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    cAMP potentiates InsP(3)-induced Ca(2+ )release from the endoplasmic reticulum in blowfly salivary glands
  6. 6786
    “…The availability of systematic algorithms, like CUSP, should enable decision making in a domain superfamily-specific manner.…”
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    CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations
  7. 6787
    “…OBJECTIVE—Experimental infection of rats with human adenovirus type 36 (Ad-36) promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the pharmacologic effect of thiozolinediones. …”
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    Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36
  8. 6788
    “…Reward-modulated spike-timing-dependent plasticity (STDP) has recently emerged as a candidate for a learning rule that could explain how behaviorally relevant adaptive changes in complex networks of spiking neurons could be achieved in a self-organizing manner through local synaptic plasticity. However, the capabilities and limitations of this learning rule could so far only be tested through computer simulations. …”
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    A Learning Theory for Reward-Modulated Spike-Timing-Dependent Plasticity with Application to Biofeedback
  9. 6789
    “…In contrast, vps25 mutant clones in a wild-type background trigger hyperplastic overgrowth in a non-autonomous manner. In addition, vps25 mutant clones also promote apoptotic resistance in a non-autonomous manner. …”
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    Common and Distinct Genetic Properties of ESCRT-II Components in Drosophila
  10. 6790
    “…Patients: At both the primary care facilities and hospital level, controls were gathered in a prospective manner (n= 275). Cases were prospective and retrospective manner collected on (n=126). …”
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    Multivariate explanatory model for sporadic carcinoma of the colon in Dukes' stages I and IIa
  11. 6791
    “…During monocyte-to-macrophage differentiation, ERα is upregulated in a time-dependent manner. Previous studies by our group demonstrated that E2 treatment attenuates production of the chemokine CXCL8 in an ER-dependent manner. …”
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    Estradiol Regulates Expression of Estrogen Receptor ERα46 in Human Macrophages
  12. 6792
    “…However, the changes in clock gene expression did not correlate in a consistent manner with those of the output genes (i.e., genes involved in the functional output of an organ). …”
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    Effects of Nocturnal Light on (Clock) Gene Expression in Peripheral Organs: A Role for the Autonomic Innervation of the Liver
  13. 6793
    “…The apparent impossibility of transitions between codon sizes in a discontinuous manner during evolution has resulted in an unbending view that the genetic code was always triplet. …”
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    Codon Size Reduction as the Origin of the Triplet Genetic Code
  14. 6794
    “…New ideas can be assessed and criticized in a meaningful manner only if they are formulated precisely. This applies to simulation studies as well as to experiments and theories. …”
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    Towards Reproducible Descriptions of Neuronal Network Models
  15. 6795
    “…Here we describe the molecular mechanism of 9-aminoacridine (9AA) mediated HIV-1 inhibition. 9AA treatment resulted in inhibition of HIV LTR transcription in a specific manner that was highly dependent on the presence and location of the amino moiety. …”
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    9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription
  16. 6796
    “…Animals responded to a respiratory exposure to rCARDS toxin in a dose and activity-dependent manner by increasing the expression of the pro-inflammatory cytokines IL-1α, 1β, 6, 12, 17, TNF-α and IFN-γ. …”
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    Analysis of Pulmonary Inflammation and Function in the Mouse and Baboon after Exposure to Mycoplasma pneumoniae CARDS Toxin
  17. 6797
    “…Finally, evidence is provided that RIP140 can repress and be induced by other nuclear receptors in a manner that suggests potential participation in other NR oscillations. …”
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    Retinoic Acid Mediates Long-Paced Oscillations in Retinoid Receptor Activity: Evidence for a Potential Role for RIP140
  18. 6798
    por Kalitsis, Paul, Saffery, Richard
    Publicado 2009
    “…BACKGROUND: Many mammalian genes are arranged in a bidirectional manner, sharing a common promoter and regulatory elements. …”
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    Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes
  19. 6799
    “…In rice panicle development, new meristems are generated sequentially in an organized manner and acquire their identity in a time- and position-dependent manner. …”
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    PANICLE PHYTOMER2 (PAP2), encoding a SEPALLATA subfamily MADS-box protein, positively controls spikelet meristem identity in rice
  20. 6800
    por Park, Bo-yeon, Chung, Jayong
    Publicado 2009
    “…When we incubated cadmium with J774 mouse macrophage cells, FPN1 mRNA levels were significantly increased in a dose- and time-dependent manner. Furthermore, the cadmium-induced FPN1 mRNA expression was associated with increased levels of FPN1 protein. …”
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    Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species
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