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  1. 6901
    “…Our data indicate that bortezomib activated autophagy in a dose- and time- dependent manner in HCC cell lines including Huh-7, Sk-Hep1, and Hep3B. …”
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    Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome
  2. 6902
    “…Of interest, the normal and LBS mutant forms of apo(a) bound to human umbilical vein endothelial cells in a similar manner, and the binding of neither was affected by lysine analogues. …”
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    Apolipoprotein(a) stimulates nuclear translocation of β-catenin: a novel pathogenic mechanism for lipoprotein(a)
  3. 6903
    “…RESULTS: The results indicated that A431 cell growth was inhibited following infection by RSV in a dose- and time-dependent manner. The most growth inhibitory effect of RSV was occurred at the MOI of 3, and 48 hour after infection. …”
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    The Oncolytic Effect of Respiratory Syncytial Virus (RSV) in Human Skin Cancer Cell Line, A431
  4. 6904
    “…Together, our data establish that NR5A2 can act in a non-redundant manner to regulate Lhb and Fshb transcription in vitro, but is dispensable in vivo.…”
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    NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo
  5. 6905
    “…SP-D agglutinated HIV and gp120 in a calcium dependent manner. SP-D inhibited the infectivity of HIV strains at both pH values of 7.4 and 5.0 in a concentration dependent manner. …”
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    Surfactant Protein D Modulates HIV Infection of Both T-Cells and Dendritic Cells
  6. 6906
    “…Moreover, we demonstrate that Stat5 promotes the initiation and maintenance of severe granulophilia in a cell autonomous manner. The results of this study show that the gain-of-function of Stat5 causes excessive granulopoiesis and prolonged survival of granulocytes in circulation. …”
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    Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung
  7. 6907
    “…SDF-1α augments E-selectin mediated ECFC adhesion and migration in a CXCR4-dependent manner.…”
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    E-Selectin Mediated Adhesion and Migration of Endothelial Colony Forming Cells Is Enhanced by SDF-1α/CXCR4
  8. 6908
    “…These results demonstrate that E2 modulates versican at the transcriptional and posttranscriptional levels in a time-dependent manner.…”
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    Estradiol induces transcriptional and posttranscriptional modifications in versican expression in the mouse uterus
  9. 6909
    “…Together, our data not only show that a rapid execution of PI-induced apoptosis requires JNK1 for upregulation of Noxa via an as yet unknown transcription factor, but also that JNK2 controls this event in an oppositional manner.…”
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    Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
  10. 6910
    “…The mitochondrial membrane potential (MMP) decreased obviously in a dose-dependent manner. The degree of DNA damage including the percentage of tail DNA, tail length and Olive tail moment (OTM) were markedly aggravated. …”
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    Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint
  11. 6911
    “…Thus, each hemisphere may not respond to manipulations of contextual predictability in an equivalent manner. This possibility was investigated by recording ERPs while presenting [in the left and right visual fields (VFs)] sentence-final words that varied over the full range of sentence-level predictability. …”
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    Two Sides of Meaning: The Scalp-Recorded N400 Reflects Distinct Contributions from the Cerebral Hemispheres
  12. 6912
    “…The inhibition of I(GABA) by resveratrol was in a reversible and concentration-dependent manner. The IC(50) of resveratrol was 28.9±2.8 µM in oocytes expressing GABA(C) receptor. …”
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    Resveratrol Inhibits GABA(C) ρ Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes
  13. 6913
    “…In addition, xyloketal B induced Akt and Erk1/2 phosphorylation in a concentration- and time-dependent manner. Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not. …”
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    Xyloketal B Exhibits Its Antioxidant Activity through Induction of HO-1 in Vascular Endothelial Cells and Zebrafish
  14. 6914
    “…With cell viability, colony formation, and flow cytometric apoptosis assays, we found that simvastatin potently suppressed cell growth of A498 and 786-O cells in a time- and dose- dependent manner. Consistently, the xenograft model performed in nude mice exhibited reduced tumor growth with simvastatin treatment. …”
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    Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT/mTOR, ERK and JAK2/STAT3 Pathway
  15. 6915
    “…RESULTS: In Krebs solution, while Dex caused an increase in the spontaneous contraction-forces in all pregnancy terms of rats in a significant dose-dependent manner, it led to a decrease in contraction-frequency in late-pregnancy term of rats. …”
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    Dexmedetomidine modifies uterine contractions in pregnancy terms of rats
  16. 6916
    por Zhang, Tao, Tan, Yan, Zhao, Rui, Liu, Zhaoyang
    Publicado 2013
    “…RESULTS: Oridonin inhibited cell growth in a time- and dose-dependent manner. The IC50 values at 48 and 72 hours were 78.3 and 31.62 µmol/l, respectively. …”
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    DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells
  17. 6917
    “…NAGly (0.3–30 μM) suppressed NCX currents in a URB597- and guanosine 5′-O-(2-thiodiphosphate) (GDPβS)-insensitive manner, [Ca(2+)](i) elevation evoked by Na(+) removal and the hyperpolarization to histamine. …”
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    N-arachidonoyl glycine suppresses Na(+)/Ca(2+) exchanger-mediated Ca(2+) entry into endothelial cells and activates BK(Ca) channels independently of GPCRs
  18. 6918
    “…The manner in which outputs are communicated is therefore of great significance to the overall success of such a scheme. …”
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    Multicellular Computing Using Conjugation for Wiring
  19. 6919
    “…Viremia titers and morbidity did not increase in a dose dependent manner; only two birds succumbed to infection and, interestingly, both were inoculated with the lowest dose of WNV. …”
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    West Nile Virus Infection in American Robins: New Insights on Dose Response
  20. 6920
    “…Insulin and leptin increase mTORC1 activity in a phosphoinositide-3-kinase (PI3K)- and protein kinase B (PKB)-dependent manner, compared to vehicle controls, whereas increasing AMPK activity inhibits mTORC1 activity and blocks the actions of the anorexigenic hormones. …”
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    Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
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