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  1. 7021
    “…CONCLUSION: The methanolic and aqueous extracts of Althaea root inhibited the tracheobronchial smooth muscle contractions of rats in a dose dependent manner, but B-adrenergic receptors do not appear to engage in this process. …”
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    Bronchodilatory and B-adrenergic effects of methanolic and aqueous extracts of Althaea root on isolated tracheobronchial smooth rat muscle
  2. 7022
    “…Interestingly, ET-1 and ET(A), but not ET(B), were expressed in a time-dependent manner in the heart. SIGNIFICANCE: Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner. …”
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    Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1
  3. 7023
    “…Correlatively, cell viability decreased in a dose-dependent manner when treated with ferulic acid. However, ferulic acid did not affect the LDH release from the cells. …”
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    Differential Effects of Methoxylated p-Coumaric Acids on Melanoma in B16/F10 Cells
  4. 7024
    “…Mechanical unloading reduced cardiomyocyte volume in a time-dependent manner. Ca(2+) release synchronicity was reduced at 8 weeks moderate unloading only. …”
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    Cardiomyocyte Ca(2+) handling and structure is regulated by degree and duration of mechanical load variation
  5. 7025
    “…RESULTS: Curcumin incubation significantly induced loss of MMP in SGC-7901 cells in a dose- dependent manner (P < 0.05); the cell apoptotic rate also dramatically increased after curcumin incubation in a dose-dependent manner (P < 0.05). …”
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    Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening
  6. 7026
    “…The DSFA generated by our method performs superior which indicates that our method is robust and has a potential for predicting the phosphorylation sites in a kinase specific manner.…”
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    A Grammar Inference Approach for Predicting Kinase Specific Phosphorylation Sites
  7. 7027
    “…Exosomes may serve as vesicles to communicate with neoplastic cells (autocrine and paracrine manner) and normal cells (paracrine and endocrine manner) and thereby suppress immune systems and regulate neoplastic growth, and metastasis. …”
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    Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer
  8. 7028
    “…This inhibitor also significantly inhibited human platelet secretion (dense and alpha granules), integrin IIb-IIIa, Akt and ERK phosphorylation, again, in a TPR-selective manner; no effects were observed in response to ADP receptor stimulation. …”
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    A Critical Role for the Transient Receptor Potential Channel Type 6 in Human Platelet Activation
  9. 7029
    “…The 3' flank profoundly affected expression in a position-dependent manner and a highly conserved sequence (HCS1) present in 5' exon 1c in a dehancer-like manner. …”
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    Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression
  10. 7030
    “…In the absence of stress, σ(S) is rapidly degraded by the AAA+ protease, ClpXP in a regulated manner that depends on the adaptor protein RssB. This two-component response regulator mediates the recognition of σ(S) and its delivery to ClpXP. …”
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    Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP
  11. 7031
    “…In the present study, ME inhibited PTP1B in a reversible competitive manner and displayed good selectivity against PTPs in vitro. …”
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    Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice
  12. 7032
    “…Electrophoretic mobility-shift assays (EMSA) show that PDTC increased binding of activating protein-1 (AP-1) in dose dependent-manner suggesting that the MAPkinase up-stream of AP-1 is involved. …”
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    A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937
  13. 7033
    “…In addition, PFDB prevented elevation of reduced glutathione, glutathione peroxidase, superoxide dismutase and catalase in the TAM-intoxicated rats in concentration-dependent manner and significantly (P < 0.05) reduced the lipid peroxidation in the liver tissue. …”
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    Hepatoprotection by active fractions from Desmostachya bipinnata stapf (L.) against tamoxifen-induced hepatotoxicity
  14. 7034
    “…RESULTS: GA not only suppressed cell proliferation, but also induced apoptosis of K562 cells in a dose-dependent manner. While it did not significantly inhibit cell proliferation of MNCs, it did induce apoptosis in a dose-dependent manner. …”
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    Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro
  15. 7035
    “…Bone regeneration involves a series of events in a coordinated manner, including recruitment of mesenchymal stem cells, induction of immune response, inflammatory activity and vascular ingrowth. …”
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    COX2 is involved in hypoxia-induced TNF-α expression in osteoblast
  16. 7036
    “…CONCLUSIONS: Our study shows an intriguing osteogenic potential of SAHA in a BMP-2-dependent manner and suggests that SAHA could be used at lower doses along with BMP-2 to treat osteoporosis.…”
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    A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2
  17. 7037
    “…S. aureus was shown to kill human monocytes in a LukAB dependent manner under both extracellular and intracellular ex vivo infection models. …”
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    Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular
  18. 7038
    “…Endogenous NIBP bound specifically to the phosphorylated IKK2 in a TNFα-dependent manner. NIBP knockdown transiently attenuated TNFα-stimulated phosphorylation of IKK2/p65 and degradation of IκBα. …”
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    Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling
  19. 7039
    “…The extract was observed to have reduced ROS in a dose-dependent manner in both HUVECs and HeLa cells. The stimulation of the CAT and SOD enzyme activities were observed to be dose-dependent as well. …”
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    Free radical scavenging ability of Aspalathus linearis in two in vitro models of diabetes and cancer
  20. 7040
    “…Since the imbalance between the levels of autophagy and energy demand may lead to cell death, we proposed that FC-induced autophagy is detrimental in a male specific manner and autophagy modulation affects injury severity in a sex-dependent manner. …”
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    Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy
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