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  1. 100041
    “…RESULTS: MPEE significantly suppressed the migration and growth of BEL-7404, HepG2 and H22 cells in a dose- and time-dependent manner through induction of apoptosis characterized by chromosomal condensation and cell cycle arrest at G0/G1 and G2/M phases. …”
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    Marchantia polymorpha L. ethanol extract induces apoptosis in hepatocellular carcinoma cells via intrinsic- and endoplasmic reticulum stress-associated pathways
  2. 100042
    “…Prosthesis-based standard fluoroscopy was performed in a timely manner after each operation, and the rate of residual cement extrusion of the two groups was estimated using T-tests and a multivariate regression analysis. …”
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    Hybrid Oxford unicompartmental knee arthroplasty has lower residual cement extrusion than cemented arthroplasty in treating end-stage unicompartmental knee osteoarthritis
  3. 100043
    “…If combined information is available in a timely manner, this would improve outbreak detection, generate further insight into mumps transmission, and guide necessary control measures. …”
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    Outbreaks of mumps genotype G viruses in the Netherlands between October 2019 and March 2020: clusters associated with multiple introductions
  4. 100044
    “…Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear. …”
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    Exploring sensory phenotypes in autism spectrum disorder
  5. 100045
    “…Studies that conduct pre-statistical harmonization of behavioral instruments rarely document their methods in a structured, reproducible manner. This is a crucial step which entails careful review, documentation and scrutiny of source data to ensure sufficient comparability between items prior to data pooling. …”
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    Pre-statistical harmonization of behavrioal instruments across eight surveys and trials
  6. 100046
    “…Drag-based kinematic models of CMEs are developed to interpret CME propagation in the heliosphere and are applied to predict their arrival times at 1 AU in an efficient manner. Several advanced MHD models have been developed to simulate realistic CME events from the initiation on the Sun until their arrival at 1 AU. …”
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    Earth-affecting solar transients: a review of progresses in solar cycle 24
  7. 100047
    “…Ten out of the 19 genes, validated in a real-world consecutive cohort, were specific of COVID-19 cancer patients independently from different cancer types and stages of the diseases, and useful to stratify patients in a COVID-19 disease severity-manner. We also unveil a transcriptional network involving gene regulators of both inflammation response and proliferation in PBMCs of COVID-19 cancer patients.…”
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    Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients
  8. 100048
    por van Vliet, Nicolien A., Bos, Maxime M., Thesing, Carisha S., Chaker, Layal, Pietzner, Maik, Houtman, Evelyn, Neville, Matt J., Li-Gao, Ruifang, Trompet, Stella, Mustafa, Rima, Ahmadizar, Fariba, Beekman, Marian, Bot, Mariska, Budde, Kathrin, Christodoulides, Constantinos, Dehghan, Abbas, Delles, Christian, Elliott, Paul, Evangelou, Marina, Gao, He, Ghanbari, Mohsen, van Herwaarden, Antonius E., Ikram, M. Arfan, Jaeger, Martin, Jukema, J. Wouter, Karaman, Ibrahim, Karpe, Fredrik, Kloppenburg, Margreet, Meessen, Jennifer M. T. A., Meulenbelt, Ingrid, Milaneschi, Yuri, Mooijaart, Simon P., Mook-Kanamori, Dennis O., Netea, Mihai G., Netea-Maier, Romana T., Peeters, Robin P., Penninx, Brenda W. J. H., Sattar, Naveed, Slagboom, P. Eline, Suchiman, H. Eka D., Völzke, Henry, Willems van Dijk, Ko, Noordam, Raymond, van Heemst, Diana
    Publicado 2021
    “…Associations between TSH and fT4 and metabolic profile were investigated in a two-stage manner: associations between TSH and fT4 and the full panel of 161 metabolomic markers were first assessed hypothesis-free, then directional consistency was assessed through Mendelian randomization, another metabolic profile platform, and in individuals with biochemically defined thyroid dysfunction. …”
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    Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling
  9. 100049
    “…Thus, a fully automated system to select L3 slice and segment muscle in an end-to-end manner is demanded. We aimed to develop a deep learning model (DLM) to select the L3 slice with consideration of anatomic variations and to segment cross-sectional areas (CSAs) of abdominal muscle and fat. …”
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    Development of a fully automatic deep learning system for L3 selection and body composition assessment on computed tomography
  10. 100050
    “…BACKGROUND: Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly identified factor with anti-inflammatory actions. …”
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    Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE(−/−) mice fed high fat diet
  11. 100051
    “…RESULTS: The prevalence of asthma was 2 per 1000 in the whole population; however, the prevalence differs by age groups in a significant manner. Age, sex, educational status, place of residence, cooking fuel, source of drinking water, household size and garbage disposal facility were significantly associated with asthma prevalence in India. …”
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    Understanding socio-economic inequalities in the prevalence of asthma in India: an evidence from national sample survey 2017–18
  12. 100052
    “…A longitudinal study will be required to validate the new proposed anticholinergic and sedative burden catalog in an evidence-based manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40266-021-00895-x.…”
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    Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models
  13. 100053
    “…CONCLUSIONS AND RELEVANCE: Administration of vilobelimab in patients with severe sepsis and septic shock selectively neutralizes C5a in a dose-dependent manner without blocking formation of the membrane attack complex and without resulting in detected safety issues. …”
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    Efficacy and Safety of Vilobelimab (IFX-1), a Novel Monoclonal Anti-C5a Antibody, in Patients With Early Severe Sepsis or Septic Shock—A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase IIa Trial (SCIENS Study)
  14. 100054
    “…Finally, the histopathological assessment revealed significantly enhanced intracellular localization of mucoinflammatory proteins including MUC5B and FIZZ1 in ozone-exposed mice in a cell-specific manner indicating the cellular sources of the proteins that are ferried in the exosomes upon ozone-induced lung injury. …”
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    Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease
  15. 100055
    “…ROR2 overexpression induced a BRCAness-like phenotype in a cell-context specific manner and rendered cells resistant to PARP inhibition. …”
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    WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer
  16. 100056
    “…Further investigation of the gut microbiomes of CVD patients in a targeted manner may elucidate microbial mechanisms with diagnostic and therapeutic implications. …”
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    Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease
  17. 100057
    “…Binary logistic regression analysis was used to assess the independent predictors of thyroid nodules in a multivariate manner. RESULTS: The 1172 subjects were remained after PSM, and differences of demographic background between subjects with and without thyroid nodules were eliminated. …”
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    Adjusted association between type 2 immunity and low risk thyroid nodules: a retrospective cohort study
  18. 100058
    “…Vitamin A activated general pathways of retinol response in a SCD genotype-dependant manner, which affected the monounsaturated fatty acid content, particularly in SCD-CC pigs. …”
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    Transcriptome shifts triggered by vitamin A and SCD genotype interaction in Duroc pigs
  19. 100059
    “…CONCLUSIONS: A smart watch can deliver access to brief wellness interventions in the field in a manner that is both feasible and acceptable to LEOs. …”
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    Acceptability of a real-time notification of stress and access to self-help therapies among law enforcement officers
  20. 100060
    “…CONCLUSIONS: Our integrated in vitro, in silico, and in vivo study revealed that AgNPs exerted toxicity in dose-, cell/organ type- and particle type-dependent manners. More importantly, a single injection of lethal-dose AgNPs (i.e., SCS and SAS) could incur severe damage to pancreas and raise blood glucose levels at the early phase of exposure. …”
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    Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo
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