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  1. 100161
    “…CONCLUSIONS: While numerous data gaps remain, these data show that significant carbapenem resistance is widespread in Africa and polymyxin resistance is also widely distributed, indicating the need to support robust AMR surveillance, antimicrobial stewardship and infection control in a manner that also addresses broader animal and environmental health dimensions. …”
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    Review and analysis of the overlapping threats of carbapenem and polymyxin resistant E. coli and Klebsiella in Africa
  2. 100162
    “…In the cohort study, serum autoantibody binding was examined in a blinded manner using tissue-based assays (TBAs) and dorsal root ganglia (DRG) neuronal cultures. …”
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    Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury
  3. 100163
    “…This is the first report which implicates the role of Ketorolac against RCC by acting as a small molecule secretagogue causing upregulation of Par-4 in autocrine and paracrine manner. Consequently, these findings suggest that Par-4 can serve as a valuable therapeutic target and a prognostic marker for the treatment of RCC.…”
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    Ketorolac modulates Rac-1/HIF-1α/DDX3/β-catenin signalling via a tumor suppressor prostate apoptosis response-4 (Par-4) in renal cell carcinoma
  4. 100164
    “…The surrogate is constructed in a computationally efficient manner as compared to methodologies using 2D B-scan image. …”
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    Buried object characterization by data-driven surrogates and regression-enabled hyperbolic signature extraction
  5. 100165
    “…Enforced expression of HSD11B1 in mouse melanomas limited the efficacy of PD-1 blockade, whereas small molecule HSD11B1 inhibitors improved responses in a CD8(+) T cell-dependent manner. Mechanistically, HSD11B1 inhibition in combination with PD-1 blockade augmented the production of interferon-γ by T cells. …”
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    Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
  6. 100166
    “…Moreover, the expression of sirtuin 1, 3, and 7 (SIRT1, SIRT3, and SIRT7) genes was increased (p < 0.05) in the liver of the HS groups that received Resv-Lipo NPs in a dose-dependent manner. Notably, the upregulation of proinflammatory cytokines in the HS group was restored in the HS groups that received Resv-Lipo NPs. …”
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    Impact of resveratrol-loaded liposomal nanocarriers on heat-stressed broiler chickens: Effects on performance, sirtuin expression, oxidative stress regulators, and muscle building factors
  7. 100167
    “…These unique features allow Ad-REIC to exert effective and selective cancer-preventative effects in the manner of an anticancer vaccine. However, the question of how the REIC/Dkk-3 protein leverages anticancer immunity has remained to be answered. …”
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    Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells
  8. 100168
    “…MiR-3180 suppressed HCC cell proliferation, migration, and invasion in an SCD1- and CD36-dependent manner in vitro. The mouse model demonstrated that miR-3180 inhibits HCC tumor growth and metastasis by inhibiting SCD1- and CD36-mediated de novo fatty acid synthesis and uptake. …”
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    MiR-3180 inhibits hepatocellular carcinoma growth and metastasis by targeting lipid synthesis and uptake
  9. 100169
    “…The C(max) and area under the plasma concentration–time curve increased in a dose-dependent manner, and the trough concentration reached steady state by week 16. …”
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    Efficacy and pharmacokinetics of ozoralizumab, an anti-TNFα NANOBODY(®) compound, in patients with rheumatoid arthritis: 52-week results from the OHZORA and NATSUZORA trials
  10. 100170
    “…Pathologists recorded tumor numbers and sizes in a standard manner. RESULTS: The inter- and intraobserver consistency of image quality features scoring was good to excellent (κ >0.75; P<0.001). …”
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    Image quality evaluation of diffusion-weighted imaging in bladder cancer: a comparison between integrated slice-specific dynamic shimming and single-shot echo-planar imaging
  11. 100171
    “…CONCLUSIONS: RPL21 promoted invasion and metastasis by regulating FA formation in a LAMP3-dependent manner during CRC progression. The interaction between RPL21 and LAMP3 may function as a potential therapeutic target against CRC. …”
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    RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation
  12. 100172
    “…CONCLUSIONS: An image-AI–based psoriasis severity assessment model has been proposed to automatically calculate PASI scores in an efficient, objective, and accurate manner. The SkinTeller app may be a promising alternative for dermatologists’ accurate assessment in the real world and chronic disease self-management in patients with psoriasis.…”
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    Artificial Intelligence–Based Psoriasis Severity Assessment: Real-world Study and Application
  13. 100173
    “…Data will be presented in a narrative and descriptive manner, summarizing key concepts, patient characteristics, and health outcomes of patients labelled as a “social admission” (and other synonymously used terms) and of those with nonacute and nonspecific complaints. …”
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    Older Adults, the “Social Admission,” and Nonspecific Complaints in the Emergency Department: Protocol for a Scoping Review
  14. 100174
    “…Future research will focus on scaling up the implementation and evaluation of PRO data collection in a contextually appropriate manner while obtaining input from providers and staff to ensure that the collected data are both applicable and actionable.…”
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    Patient-Reported Outcomes Collection at an Urban HIV Clinic Associated With a Historically Black Medical College in the Southern United States: Qualitative Interview Study Among Patients With HIV
  15. 100175
    “…CONCLUSIONS: Implementation research conducted in Benin, and indeed throughout sub-Saharan Africa, is often implemented in a top-down manner, with both implementation determinants and strategies derived in the global North. …”
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    Rapid ethnography and participatory techniques increase onchocerciasis mass drug administration treatment coverage in Benin: a difference-in-differences analysis
  16. 100176
    “…RESULTS: After 12 years of rotation, nutrient fluxes were affected in the soil in an inconsistent manner, with K, NO(3), Mg, Ca, P, and Fe fluxes variably impacted by rotation depending on the year and site of sampling. …”
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    Crop rotation significantly influences the composition of soil, rhizosphere, and root microbiota in canola (Brassica napus L.)
  17. 100177
    “…Conflicts between these values were discussed in terms of operational principles that were required for epitope compatibility to be implemented in an acceptable manner: the needs for Flexibility, Accountability, Transparent Communication and a Transition Plan. …”
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    Public values and guiding principles for implementing epitope compatibility in kidney transplantation allocation criteria: results from a Canadian online public deliberation
  18. 100178
    “…Using two interventions, we aim to support medical students in shifting towards challenge-oriented stress responses and improved communication performance: (1) stress arousal reappraisal (SAR), which guides individuals to reinterpret their stress arousal as an adaptive and beneficial response for task performance; (2) worked examples (WE), which demonstrate how to BBN in a step-by-step manner, offering structure and promoting skill acquisition. …”
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    From threat to challenge—Improving medical students’ stress response and communication skills performance through the combination of stress arousal reappraisal and preparatory worked example-based learning when breaking bad news to simulated patients: study protocol for a randomized controlled trial
  19. 100179
    “…Moreover, nuclear H(2)O(2) levels were IR-induced in a dose-dependent manner only under normoxia, and directly correlated with the DNA double-strand breaks. …”
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    Radio-resistance of hypoxic tumors: exploring the effects of oxygen and X-ray radiation on non-small lung cancer cell lines
  20. 100180
    “…Participants felt that the intervention helped them organize their knowledge in a structured manner and consciously link their practice elements to concepts in ML. …”
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    Assessing the impact of a knowledge translation intervention on physical therapists’ self-efficacy and implementation of motor learning practice
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