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100561por Gao, Yanyun, Zens, Philipp, Su, Min, Gemperli, Camila Anna, Yang, Haitang, Deng, Haibin, Yang, Zhang, Xu, Duo, Hall, Sean R. R., Berezowska, Sabina, Dorn, Patrick, Peng, Ren-Wang, Schmid, Ralph Alexander, Wang, Wenxiang, Marti, Thomas Michael“…In the cell line A549, CDA and TYMP expression was further increased by chemotherapy in a time-dependent manner, which was also observed in the KRAS-addicted NSCLC cell lines H358 and H411. …”
Publicado 2021
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100562por Guo, Song, Huang, Shuyun, Jiang, Xi, Hu, Haiyang, Han, Dingding, Moreno, Carlos S., Fairbrother, Genevieve L., Hughes, David A., Stoneking, Mark, Khaitovich, Philipp“…The placenta is one of the few solid human tissues that can be collected in substantial numbers in a controlled manner, enabling quantitative analysis of transient biomolecules such as RNA transcripts. …”
Publicado 2021
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100563por Wang, Aiwei, Gao, Yang, Wang, Jingjing, Tong, Tomas K, Sun, Yan, Yu, Siyue, Zhao, Hong, Zou, Daozhi, Zhang, Ziheng, Qi, Yuling, Zuo, Nan, Bu, Danran, Zhang, Dexing, Xie, Yaojie, Baker, Julien S“…The intensity of the activities will increase in a progressive manner. Participants in the CG will receive no program during the study period, but the same PA program will be provided to them after the completion of the study. …”
Publicado 2021
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100564por Shi, Jian, Zhao, Lian, Duncan, Brittany, Su, Jie, Manzo, Jale, Liu, He, Zhu, Yuan-Shan“…These HCM and TGF-β1 effects were inhibited by a specific TGFβ receptor inhibitor, LY2157299, as well as by 17α-estradiol in a dose-dependent manner. Most intriguing, 17α-estradiol significantly inhibited the HCM and TGF-β1-induced PCa cell migration and invasion at very low nanomolar concentrations, presumably mediated through estrogen receptor β. …”
Publicado 2021
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100565por Hausken, Krist N, Noel, Sekoni D, Kim, Han Kyeol, Carroll, Rona Stephanie, Kaiser, Ursula B“…Reproduction is regulated by the gonadotropins, LH and FSH, which are synthesized and secreted by pituitary gonadotrophs in response to hypothalamic GnRH in a pulse frequency dependent manner. The gonadotroph decodes GnRH pulsatility via the GnRH receptor (GnRHR), which increases in expression and cell surface density before estrus and is responsible for downstream signaling cascades that differentially favor gonadotropin expression. …”
Publicado 2021
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100566por Michel, Pierre, Ngo, Nicolas, Pons, Jean-François, Delliaux, Stéphane, Giorgi, Roch“…This statistical approach known as feature selection can be performed through regression or classification, in a supervised or unsupervised manner. Several feature selection approaches using different mathematical concepts have been described in the literature. …”
Publicado 2021
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100567“…RESULTS: Our data indicated LncRNA SNHG15 upregulated c-Myc to facilitate BC progression by sponging miR-451 in a competing endogenous RNA (ceRNA)-dependent manner in vitro and in vivo. Specifically, LncRNA SNHG15 and c-Myc were upregulated, while miR-451 was downregulated in BC cells and clinical tissues, compared to their normal counterparts. …”
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100568por Seguella, Luisa, Pesce, Mirella, Capuano, Riccardo, Casano, Fabrizio, Pesce, Marcella, Corpetti, Chiara, Vincenzi, Martina, Maftei, Daniela, Lattanzi, Roberta, Del Re, Alessandro, Sarnelli, Giovanni, Gulbransen, Brian D., Esposito, Giuseppe“…Glial expression of GFAP and TLR4 increased in parallel in the duodenal myenteric plexuses, nodose ganglia, and hippocampus in a time-dependent manner. Glial changes were associated with a progressive decrease in BDNF, and DCX expression, fewer neuronal dendritic spines, and anxiogenic/depressive symptoms in HFD-treated mice. …”
Publicado 2021
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100569“…CCL21 induced the MALAT1 expression in a time- and dose-dependent manner. Functionally, MALAT1 targeted miR-202-3p but upregulated SRSF1 and activated mTOR. …”
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100570por Rattner, Rachel, Thapa, Shree Prasad, Dang, Tyler, Osman, Fatima, Selvaraj, Vijayanandraj, Maheshwari, Yogita, Pagliaccia, Deborah, Espindola, Andres S., Hajeri, Subhas, Chen, Jianchi, Coaker, Gitta, Vidalakis, Georgios, Yokomi, Raymond“…S. citri is transmitted in a persistent propagative manner by the beet leafhopper, Neoaliturus tenellus in North America and Circulifer haematoceps in the Mediterranean region. …”
Publicado 2021
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100571por Ehsan, Muhammad, Hu, Rui-Si, Hou, Jun-Ling, Elsheikha, Hany M., Li, Xiao-Dong, Liang, Pan-Hong, Zhu, Xing-Quan“…Additionally, rFg-CaBP4-treated monocytes exhibited a marked increase in the expression of the major histocompatibility complex (MHC) class-II molecule (MHC-II) and a decrease in MHC-I expression, in a dose-dependent manner. CONCLUSIONS: These findings provide additional evidence that calcium-binding EF-hand proteins play roles in host-parasite interaction. …”
Publicado 2021
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100572por Xi, Yang, Xu, Qian, Huang, Qin, Ma, Shengchao, Wang, Yushi, Han, Chunchun, Zhang, Rongping, Wang, Jiwen, Liu, Hehe, Li, Liang“…The phenotypic effect of these two mutations suggested that they can regulate the size of black spots in a dose-dependent manner, and Chr4: 10,180,939 T > C was the major allele locus. …”
Publicado 2021
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100573por Klemm, Philipp, Kleyer, Arnd, Tascilar, Koray, Schuster, Louis, Meinderink, Timo, Steiger, Florian, Lange, Uwe, Müller-Ladner, Ulf, Knitza, Johannes, Sewerin, Philipp, Mucke, Johanna, Pfeil, Alexander, Schett, Georg, Hartmann, Fabian, Hueber, Axel J, Simon, David“…New didactic approaches using innovative technologies such as virtual reality (VR) apps could be helpful to demonstrate disease manifestations as well as joint pathologies in a more comprehensive manner. However, the potential of using a VR education concept in IA has not yet been evaluated. …”
Publicado 2021
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100574por Richardson, Rachael T., Thompson, Alex C., Wise, Andrew K., Ajay, Elise A., Gunewardene, Niliksha, O’Leary, Stephen J., Stoddart, Paul R., Fallon, James B.“…Inferior colliculus responses to optical stimuli were detected in a cochleotopic manner in all mice with ChR2-H134R expression. There was a significant correlation between lower activation thresholds in mice and higher proportions of transduced neurons. …”
Publicado 2021
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100575por Khojaly, Ramy, Mac Niocaill, Ruairí, Shahab, Muhammad, Nagle, Matthew, Taylor, Colm, Rowan, Fiachra E., Cleary, May“…To our knowledge, immediate weight-bearing (IWB) following ORIF of all types of unstable ankle fractures has not been investigated in a controlled prospective manner in recent decades. This pragmatic randomised-controlled multicentre trial will investigate immediate weight-bearing following ORIF of all ankle fracture patterns in the usual care condition. …”
Publicado 2021
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100576por Al Refaey, Heba R., Newairy, Al-Sayeda A., Wahby, Mayssaa M., Albanese, Chris, Elkewedi, Mohamed, Choudhry, Muhammad Umer, Sultan, Ahmed S.“…RESULTS: MH treatment showed a proliferative inhibitory effect on tested cells in a dose-dependent manner with IC(50) concentration of (6.92 ± 0.005%) and (18.62 ± 0.07%) for HepG2 and Hep3B cells, respectively, and induced dramatic morphological changes of Hep-G2 cells, which considered as characteristics feature of apoptosis induction after 48 h of treatment. …”
Publicado 2021
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100577por Zhang, Na, Wu, Xinrui, Tian, Mengyuan, Wang, Xiaolei, Ding, Jian, Tian, Yong, Liang, Chengcai, Zeng, Zhi, Xiang, Hua, Tan, Hongzhuan“…Structured questionnaires were administered, and physical examinations were performed in the same manner for cases and controls. Univariate and multivariate logistic regression analyses with adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were used to examine the association between risk factors and ischaemic stroke. …”
Publicado 2021
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100578“…CONCLUSION: While norepinephrine and dobutamine improved cardiac index equally, it was obtained in different manners. Dobutamine significantly improved the right ventricular function and the arterio-ventricular coupling. …”
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100579“…BACKGROUND: The US national surveys and data from legal adult use cannabis states show increases in the prevalence of cannabis use among older adults, though little is known about their manner of cannabis consumption. Here, we examine cannabis use frequency, routes of cannabis administration, and co-use with alcohol, focusing on adults aged 50–64 and ≥65. …”
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100580por Kitamoto, Takumi, Saegusa, Ryuichi, Tashiro, Takuma, Sakurai, Tomomi, Yokote, Koutaro, Tokuyama, Takahiko“…Therefore, WBV training can be proposed as comprehensive therapy in a safe manner and potentially has a positive effect on health-related quality of life in elderly patients with T2DM. …”
Publicado 2021
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