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100621“…RESULTS: High glucose (HG) treatment reduced the expression of CASC2 in human glomerular mesangial cells (HMCs) in a time-dependent manner. CASC2 overexpression suppressed HG-induced proliferation, inflammation and fibrosis in HMCs. miR-135a-5p was validated as a target of CASC2, and CASC2 restrained HG-induced influences in HMCs partly by down-regulating miR-135a-5p. miR-135a-5p bound to the 3ʹ untranslated region (3ʹUTR) of TIMP3, and CASC2 positively regulated TIMP3 expression by sponging miR-135a-5p in HMCs. miR-135a-5p silencing inhibited HG-induced effects in HMCs partly by up-regulating its target TIMP3. …”
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100622“…IMPLICATIONS: Nicotine exposure alters intrauterine infection and inflammation in a dose-dependent manner, potentially impacting fetal development and programming. …”
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100623“…SEVO and ISO inhibited KCl-induced vasoconstriction in a concentration-dependent manner and were suppressed by LY294002 (10 µM) and Y27632 (1 µM). …”
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100624“…Benefits from all types of exercise seem to occur in an intensity-dependent manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-021-00846-y.…”
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100625“…In vitro, glucose could induce an increase in miR-504 and miR-935, whereas a decrease in MEK5 and MEF2C in a dose-dependent manner. Overexpression of miR-504 and miR-935 led to the decreased expression of MEK5 and MEF2C, decreased proliferation rate of Leydig cells, increased apoptotic rate, and decreased secretion of testosterone. …”
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100626por Blasi, Livio, Bordonaro, Roberto, Serretta, Vincenzo, Piazza, Dario, Firenze, Alberto, Gebbia, Vittorio“…Oncology care health professionals from various oncology subspecialties at oncology departments in multiple hospitals (academic and general hospitals as well as tertiary centers and community hospitals) are involved in a nonhierarchic manner. VMTB employs an innovative, virtual, cloud-based platform to share anonymized medical data that are discussed via a videoconferencing system both satisfying security criteria and compliance with the Health Insurance Portability and Accountability Act. …”
Publicado 2021
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100627por Proskocil, Becky J., Wai, Karol, Lebold, Katherine M., Norgard, Mason A., Michaelis, Katherine A., De La Torre, Ubaldo, Cook, Madeline, Marks, Daniel L., Fryer, Allison D., Jacoby, David B., Drake, Matthew G.“…In contrast, TLR7 antibodies labeled small- and medium-sized neurons in wild-type and TLR7 KO mice in a TLR7-independent manner. Influenza A infection caused significant weight loss and upregulation of TLR7 in the spleens, but not in vagal ganglia, in mice. …”
Publicado 2021
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100628por Kang, Xun, Sun, Tao, Zhang, Liang, Zhou, Chunyu, Xu, Zhongsheng, Du, Mengmeng, Xiao, Shilin, Liu, Yun, Gong, Mingfu, Zhang, Dong“…The NPs’ MR imaging implied that the T(2) can be shortened by Fe(3)O(4)-Au(shell) NPs in a concentration-dependent manner, and the Fe(3)O(4)-Au(shell) NPs coated with PEG at the molar ratio of 160 (PEG: NPs) showed the highest transverse relaxivity (r(2)) of 216 mM(−1)s(−1). …”
Publicado 2021
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100629por D’Amico, Elizabeth J., Dickerson, Daniel L., Rodriguez, Anthony, Brown, Ryan A., Kennedy, David P., Palimaru, Alina I., Johnson, Carrie, Smart, Rosanna, Klein, David J., Parker, Jennifer, McDonald, Keisha, Woodward, Michael J., Gudgell, Ninna“…BACKGROUND: Nonmedical use of prescription opioids (defined as taking opioid medications for hedonic effects or in a manner other than prescribed) and the use of heroin have emerged in recent years as major public health concerns in the United States. …”
Publicado 2021
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100630por Chen, Jinying, Wijesundara, Jessica G., Patterson, Angela, Cutrona, Sarah L., Aiello, Sandra, McManus, David D., McKee, M. Diane, Wang, Bo, Houston, Thomas K.“…Barriers include: (1) limitations of conducting symptom assessment by provider-initiated follow-up calls (I); (2) difficulty connecting patients and providers in a timely manner (R); (3) suboptimal coordination for transitional care among primary care and cardiology providers (R); and (4) lack of emphasis on post-discharge follow-up call reimbursement among cardiology clinics (EE). …”
Publicado 2021
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100631por Carstensen, Saskia, Gress, Christina, Erpenbeck, Veit J., Kazani, Shamsah D., Hohlfeld, Jens M., Sandham, David A., Müller, Meike“…CONCLUSION: Prostaglandin D(2) metabolites initiate ILC2 migration and IL-5 and IL-13 cytokine secretion in a DP(2) dependent manner. Our data indicate that metabolites may be important for in vivo eosinophil activation and ILC2 migration and to a lesser extent for ILC2 cytokine secretion. …”
Publicado 2021
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100632por Xiang, Menglong, Wang, Zhi, Zou, Peng, Ling, Xi, Zhang, Guowei, Zhou, Ziyuan, Cao, Jia, Ao, Lin“…The levels of global DNA methylation were significantly decreased by DEB treatment in a dose-dependent manner within each 5-MTHF concentration in TK-6 cells (ANOVA, P < 0.01), and were significantly increased by 5-MTHF supplementation within each DEB concentration (ANOVA, P < 0.01). …”
Publicado 2021
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100633“…SPION-labelled/pretreated MSCs regulate macrophage polarization in a manner dependent on MSC-expressed TRAF1 protein. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-021-02593-2.…”
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100634por Spaccaferri, Guillaume, Calba, Clémentine, Vilain, Pascal, Garras, Loïc, Durand, Cécile, Pilorget, Corinne, Atiki, Nahida, Bernillon, Pascale, Bosc, Laëtitia, Fougère, Erica, Hanon, Jean-Baptiste, Henry, Valérie, Huchet-Kervella, Caroline, Martel, Mélanie, Pontiès, Valérie, Mouly, Damien, Rolland du Roscoat, Enguerrand, Le Vu, Stéphane, Desenclos, Jean-Claude, Laporte, Anne, Rolland, Patrick“…This surveillance system identified the most affected communities in a timely manner. A level of criticality was defined for each cluster to take into consideration the risk of spreading within and outside the community of occurrence, and the health impact within the community. …”
Publicado 2021
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100635por Saiz, Maria Laura, De Diego, Marta L., López-García, Darío, Corte-Iglesias, Viviana, Baragaño Raneros, Aroa, Astola, Ivan, Asensi, Victor, López-Larrea, Carlos, Suarez-Alvarez, Beatriz“…Moreover, the addition of VPA 1 h post-infection with SARS-CoV-2 reduces the production of infectious viruses in a dose-dependent manner without significantly modifying the genomic and subgenomic messenger RNAs (gRNA and sg mRNAs) or protein levels of N protein. …”
Publicado 2021
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100636por Xie, Shucai, Jiang, Xili, Doycheva, Desislava Met, Shi, Hui, Jin, Peng, Gao, Ling, Liu, Rui, Xiao, Jie, Hu, Xiao, Tang, Jiping, Zhang, Lina, Zhang, John H.“…RESULTS: The expression of GPR39 and pathway-related proteins, SIRT1, PGC-1α and Nrf2 were increased in a time-dependent manner, peaking at 24 h or 48-h post-HIE. Intranasal administration of TC-G 1008 reduced the percent infarcted area and improved short-term and long-term neurological deficits. …”
Publicado 2021
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100637por Barakat, Sarah, Touyz, Stephen, Maloney, Danielle, Russell, Janice, Hay, Phillipa, Cunich, Michelle, Lymer, Sharyn, Kim, Marcellinus, Madden, Sloane, Miskovic-Wheatley, Jane, Maguire, Sarah“…Further research is required into innovative digital modes of treatment delivery with the capacity to service mental health needs in an accessible and affordable manner. Self-help programs may also appeal to individuals who are more reluctant to engage in traditional face-to-face treatment formats. …”
Publicado 2021
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100638por Xie, Xiaoyu, Lv, Huanran, Liu, Chenxi, Su, Xiaonan, Yu, Zhen, Song, Shouyang, Bian, Hongjun, Tian, Miaomiao, Qin, Chengyong, Qi, Jianni, Zhu, Qiang“…Furthermore, HBeAg promoted the proliferation, motility, and contraction of hepatic stellate cells (HSCs) in a macrophage-dependent manner, but not alone. PI3K-AKT-mTOR and p38 MAPK signaling pathway were responsible for motility phenotype of HSCs, while the Smad-dependent TGF-β signaling pathway for proliferation and contraction of them. …”
Publicado 2021
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100639por Wang, Gang, Si, Tianmei, Imperato, Joseph S., Yang, LiLi, Zou, Kelly H., Jin, Ying Olive, Pappadopulos, Elizabeth A., Yan, Lei, Li, Jim Z., Yu, Wei“…Patients achieving stable daily dose of sertraline in an efficient and timely manner were more likely to remain persistent throughout 1‐year follow‐up.…”
Publicado 2021
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100640“…In terms of equity the article particularly raises issues with the manner in which support was made available only to some consumers (e.g. on-grid, off-grid, regulated, or non-regulated, post-paid or pre-paid), or only for specific fuels, and not others. …”
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