“…However, most existing contextual dissimilarity/similarity learning algorithms work in an unsupervised manner, which does not utilize the information of the known class labels of proteins in the database. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Homozygous variant genotypes of rs2981582 were strongly related to lymph node negative breast cancer (OR = 3.33, P = 6 × 10(−7)) and the minor allele of rs2981582 was associated with increased risk of ER+ tumors (OR = 1.57, P = 0.02; OR = 2.15, P = 0.001, for heterozygous and homozygous variant genotypes, respectively) and increased risk of distant metastasis development (OR = 2.30, P = 4 × 10(−3); OR = 3.57, P = 6 × 10(−5), for heterozygous and homozygous variant genotypes, respectively) in a dose dependent manner. The association for rs8051542 was stronger for high-grade SBR tumors (OR = 2.54, P = 2 × 10(−4)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pretreating small DRG sensory neurons with CCL2 also increased the density of TTX-resistant Na(+) currents with a concentration-dependent manner (EC(50) value = 0.7 ± 0.06 nM). The Na(v)1.8 mRNA level was significantly increased in DRG neurons pretreated with CCL2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, this work suggests p38K and ERK1/2 pathways may regulate gene expression in a complementary manner to fine tune the IL-1β-mediated astrocyte inflammatory response. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Almost three-quarters (71%) supported continuation of the program in an unqualified manner. The physicians with the most positive attitudes to the program were over age 44, independent contract physicians, and either board-certified in internal medicine or without any board-certification (i.e., residents or general practitioners). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the V(T) of [(11) C]N-methyl-SSR504734 was found to decrease after pretreatment of SSR504734 in a dose-dependent manner. GlyT1 occupancy was calculated to be 45% and 73% at 1.5 and 4.5 mg/kg of SSR504734, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…More integrated working between care homes and primary health services has the potential to improve quality of care in a cost- effective manner, but strategic decisions to create more formal arrangements are required to bring this about. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although many putative predictors of treatment response have been reported, most were identified through retrospective analyses of existing datasets and very few have been replicated in a manner that can impact clinical practice. One major confound in previous studies examining predictors of treatment response is the patient’s treatment history, which may affect both the predictor of interest and treatment outcomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the impact of the deletion of certain RPs affected biofilm formation in a manner that was dependent on temperature and/or oxygen concentration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Data were retrieved in a systematic manner and analyzed using Review Manager and STATA Statistical Software. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Following single intranasal dosing, BCQB was rapidly absorbed with a median time to maximum concentration (t(max)) of 8 minutes for 45, 90, and 180 mg dose groups; the plasma concentration of BCQB decreased in a biphasic manner with the mean half-life (t(1/2)) of 8.5 hours; the maximum concentration (C(max)) and area under the plasma concentration-time curve (AUC) of BCQB increased linearly across the examined dose range of 45–180 μg. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: These findings demonstrate a novel allele of the paired box gene 6 (Pax6) that affects lens development in a semidominant manner leading to a classical small-eye phenotype. …”
Enlace del recurso
Enlace del recurso

“…Another striking example was recently documented using Pseudomonas aeruginosa which is able to target and kill bacteria in a T6SS-dependent manner, therefore promoting the establishment of bacteria in specific microbial niches and competitive environment(8,9,10). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Because services are not centrally coordinated, they are provided in a manner that is inconsistent and incoherent. Since the first children’s hospice opened in 1982, the epidemiology of life-limiting conditions has changed with more children living longer, and many requiring transfer to adult services. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: It is observed that CC is better indicator of cores than CR, implying that Salmonellosis manifests itself in a highly localized manner. Thus, use of MiSTIC is promising & provides a way for identifying disease “hot-spots”. …”
Enlace del recurso

“…RESULTS: EESP treatment reduced tumor volume and tumor weight but had no effect on body weight change in CRC mice; decreased HT-29 cell viability in a dose-dependent manner, suggesting that EESP displays therapeutic efficacy against colon cancer growth in vivo and in vitro, without apparent toxicity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The mechanism of action of DAP involves interactions with the cell membrane in a calcium-dependent manner, mainly at the level of the bacterial septum. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In cultured human aortic ECs (HAECs), L5 upregulated CRP expression in a dose- and time-dependent manner up to 2.5-fold (P<0.01), whereas the least electronegative subfraction, L1, had no effect. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our study shows that the expression of paralogous genes encoding RPs was regulated in a stress-specific manner in Arabidopsis roots, presumably resulting in an altered composition of ribosomes and biased translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: These data suggest that dopaminergic tone regulates ion channel density in a concentration and time dependent manner. The D1R- PKA axis, along with Erk and mTOR are necessary for the persistent increase in LP I(A) induced by high affinity D1Rs.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso