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  1. 101121
    “…Detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), Wnt-5a mRNA in the OA-like chondrocytes were upregulated in a time-dependent manner, indicating that OA-like chondrocytes were successfully constructed. …”
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    Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes
  2. 101122
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    Impact of new traumatic or stressful life events on pre-existing PTSD in traumatized refugees: results of a longitudinal study
  3. 101123
    “…Interestingly, the cells were fully capable of producing the cytokine when stimulated in a T cell receptor (TCR)-independent manner but failed to do so in TCR-dependent stimulation. …”
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    Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India
  4. 101124
    “…CONCLUSION: It is the first demonstration that 3DG was capable of accumulating in intestinal tissue and thereby decreased secretion of GLP-1 and insulin in a similar manner. 3DG-treated rats developed impaired glucose regulation (IGR) with obviously pancreatic islet cell dysfunction. …”
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    Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats
  5. 101125
    “…Our novel findings describe how retinal neurons internalise Aβ to transiently impair MAP-2 in a hitherto unreported manner. MAP-2 dysfunction is reported in AMD retinas, and is thought to be involved in remodelling and plasticity of post-mitotic neurons. …”
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    The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)
  6. 101126
    “…The mice were euthanized in a timely manner, and the eyecups were dissected from enucleated eyes. …”
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    PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression
  7. 101127
    “…Cells that were prepared in a similar manner but maintained under atmospheric pressure served as a control. …”
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    AB276. SPR-03 In vitro evaluation of hydrostatic pressure on ATP release and Caspase-1 activation in rat urothelial cells
  8. 101128
    “…FAK inhibition reduced pS727-STAT3 within mitochondria and reduced mitochondrial function in a non-transcriptional manner, as shown by co-treatment with actinomycin. …”
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    Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3
  9. 101129
    “…The app includes self-help materials and exercises based on CBT for depression, presented in a tailored manner and incorporating gamification elements aimed at boosting motivation to use the app. …”
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    Using a smartphone app to reduce cognitive vulnerability and mild depressive symptoms: Study protocol of an exploratory randomized controlled trial
  10. 101130
    “…Then the related proteins of PTEN-PI3K pathway was proved not to be affected, but the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) was activated by a concentration- and time- dependent manner, meaning that it may be associated with AMPK. …”
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    Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
  11. 101131
    “…For instance, the administration of phosphorothioate (PS)-modified CpG ODNs can induce adverse systemic effects, such as splenomegaly, in a dose-dependent manner. Therefore, a reduced dose of CpG ODN might be crucial when used as vaccine adjuvant for clinical purposes. …”
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    Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice
  12. 101132
    “…However, the addition of co-mingling before weaning in combination with grouping familiar pigs together after weaning improved performance in an additive manner.…”
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    Intermittent suckling with or without co-mingling of non-littermate piglets before weaning improves piglet performance in the immediate post-weaning period when compared with conventional weaning
  13. 101133
    “…In vitro, ALA/SFC reduced lipid content in mouse 3T3-L1 adipocytes in a dose dependent manner, and enhanced glucose uptake in 3T3-L1 adipocytes by 70–90% and rat L6 myoblasts by 30% at 6 h. …”
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    5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function
  14. 101134
    “…We show that osteoprotegerin secretion is regulated by Interleukin-1beta in a p38- and p42/44-dependent manner. We also demonstrate that osteoprotegerin knockdown represses Interleukin-1beta expression, Interleukin-1beta-mediated breast cancer cell invasion and MMP3 expression. …”
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    Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells
  15. 101135
    “…The antioxidants inclusion also inhibited volatile flavoring compounds particularly aldehydes like hexanal and pentanal in a dose dependent manner (p ≤ 0.05). Lowest hexanal values reported in T(6) as 2488 ± 103 followed by T(4) (3701 ± 111) at the start of the trial whereas highest in T(0) (control) as 54,768 ± 431 that were increased to 9569 ± 607, 112,550 ± 897 and 359,826 ± 1285, correspondingly. …”
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    Oxidative stability and lipid oxidation flavoring volatiles in antioxidants treated chicken meat patties during storage
  16. 101136
    “…The activities of ascorbate peroxidase (APX) and glutathione S-transferase (GST) upregulated due to Cd treatment in dose-dependent manners, while glutathione reductase (GR) and glutathione peroxidase (GPX) increased only at 0.5 mM CdCl(2) and decreased at higher dose. …”
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    Hydrogen Peroxide Pretreatment Mitigates Cadmium-Induced Oxidative Stress in Brassica napus L.: An Intrinsic Study on Antioxidant Defense and Glyoxalase Systems
  17. 101137
    “…Here we describe our experience of implementing and sustaining an inpatient nutritional rehabilitation protocol designed to strategically prepare patients with EDs and their families for discharge to a home setting in an efficient and effective manner from a general adolescent medicine unit. We report outcomes at admission, discharge, and 4-weeks follow-up. …”
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    Outcomes of an inpatient medical nutritional rehabilitation protocol in children and adolescents with eating disorders
  18. 101138
    “…Because acquisition and maintenance of anti-malarial antibodies depend on parasite exposure, seroprevalence rates could be used as a reliable tool for assessing malaria endemicity and an adjunct measure for monitoring transmission in a rapid and cost-effective manner. METHODS: This systematic review synthesizes the existing literature on seroprevalence of malaria in the Brazilian Amazon Basin. …”
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    A systematic review on malaria sero-epidemiology studies in the Brazilian Amazon: insights into immunological markers for exposure and protection
  19. 101139
    “…Osteogenesis of diabetic PDCs was rescued by rhBMP-2/7 or rhBMP-2/7 + rhIGF-1 in both normal and high glucose cultures in a dose-dependent manner. Diabetic BMSCs, however, only responded to 300 ng/nl rhBMP-2/7 with/without 100 ng/ml rhIGF-1 in normal but not high glucose osteogenic culture. …”
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    Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue
  20. 101140
    “…RESULTS: PEG-SMRwt-Clu and PEG-SMRwt peptides inhibited the growth of both of MCF-7 (estrogen responsive, ER+) and MDA-MD-231 (estrogen non-responsive, ER-) human breast cancer cells in a dose and time-dependent manner, without inducing cytotoxic effects. The SMRwt peptide, combined with paclitaxel, induced G2/M phase cell cycle arrest on MCF-7 and MDA-MB-231 cells but did not promote apoptosis. …”
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    Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells
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