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101221por Palmer, Jennifer A., Mor, Vincent, Volandes, Angelo E., McCreedy, Ellen, Loomer, Lacey, Carter, Phoebe, Dvorchak, Faye, Mitchell, Susan L.“…This report’s objectives were to apply PRECIS-2 in a novel manner during the actual conduct of the PROVEN trial to assess how dynamic adaptations shifted implementation to either a more explanatory or a more pragmatic approach. …”
Publicado 2018
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101222por Zhou, Ya-Lan, Yao, Qiu-Mei, Zhou, Jiao, Chang, Yan, Li, Jin-Lan, Wang, Ya-Zhe, Wu, Hong-Ping, Chen, Yu-Hong, Liu, Yan-Rong, Huang, Xiao-Jun, Ruan, Guo-Rui“…In vitro treatment with SG611-PDCD5 in combination with low-dose daunorubicin elicited more potent anti-proliferative and proapoptotic effects in leukemic cells in a dose-dependent manner. The Chou-Talalay analysis revealed synergistic anti-proliferative effects in all of the above cell lines. …”
Publicado 2018
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101223“…Overall, this study along with available information in the literature indicated that a multifaceted relationship exists between PHB and sex steroids, which may work in a cell/tissue type- and sex-specific manner.…”
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101224por Li, Xiaoying, Hong, Xin, Gao, Xianshu, Gu, Xiaobin, Xiong, Wei, Zhao, Jing, Yu, Hongliang, Cui, Ming, Xie, Mu, Bai, Yun, Sun, Shaoqian“…MeJ could inhibit the 11-ketoprostaglandin reductase activity of AKR1C3 in a dose-dependent manner in KY170R cells. Incubation of KY170R cells with 200 µmol/L of MeJ for 24 h reduced the expression of PGF2 by roughly 30% (P<0.05). …”
Publicado 2018
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101225por Wu, Gang-Yong, Wu, Ting, Xu, Bai-Da, Shi, Yi-Cheng, Cheng, Zhi-Yuan, Zhang, Xiao, Wang, Xiao, Zong, Gang-Jun“…Injection of recombinant PTH significantly increased PTH expression and reduced BNP expression in dose-dependent manners (P<0.05). These findings demonstrated that PTH can improve cardiac function in rats with ADR-induced CM, suggesting a potential therapeutic application for PTH in non-ischemic CM.…”
Publicado 2018
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101226por Martins, Gisele M., Teixeira, Marília B. C. G., Silva, Marcos V., Neofiti-Papi, Bianca, Miranda-Rodrigues, Manuela, Brum, Patricia C., Gouveia, Cecilia H. A.“…Later, we found that mice with single-gene inactivation of α2C-AR (α2C-AR(−/−)) present low bone mass in the femur and HBM in the vertebra, but that both skeletal sites are resistant to TH-induce osteopenia, showing that the SNS actions occur in a skeletal site-dependent manner, and that thyrotoxicosis depends on α2C-AR signaling to promote bone loss. …”
Publicado 2018
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101227por Alam, Md. Kausar, Brabant, Michelle, Viswas, Raja Solomon, Barreto, Kris, Fonge, Humphrey, Ronald Geyer, C.“…Use of the SpyTag/SpyCatcher protein ligase system allows Tri-scFvs to be rapidly constructed in a simple, modular manner, which can be easily applied to scFvs or other antibody fragments targeting other antigens.…”
Publicado 2018
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101228por Zhang, Jia-Qiang, Yang, Quan-Yong, Xue, Fu-Shan, Zhang, Wei, Yang, Gui-Zhen, Liao, Xu, Meng, Fan-Min“…METHODS: Forty children aged 3 to 12 year, scheduled for elective congenital heart disease repair surgery with CPB, were randomized into 2 groups of equal size to receive the following treatments in a double-blind manner: placebo (control group) and thyroid tablet 0.4 mg/kg (trial group) taken orally once a day for 4 days before surgery. …”
Publicado 2018
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101229
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101230“…RESULTS: EET significantly inhibited the proliferation of HepG2 and SMMC-7721 cells in a concentration- and time-dependent manner (P<0.05). After treatment with 0, 50, 100, 150, 200, and 250 μg/mL EET for 24 h, HepG2 the proliferation rates were 100.00%±0.00%, 90.33%±1.76%, 67.67%±0.88%, 47.33%±0.88%, 37.00%±0.00%, and 30.33%±0.67%, respectively, and 100.00%±0.00%, 18.25%±1.05%, 19.99%±0.59%, 23.42%±0.46%, 29.70%±0.79%, and 29.8%±0.41% for SMMC-7721 cells, respectively. …”
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101231por Jang, Jihoon, Oh, Hakjin, Nam, Daleum, Seol, Wongi, Seo, Mi Kyoung, Park, Sung Woo, Kim, Hyung Gun, Seo, Hyemyung, Son, Ilhong, Ho, Dong Hwan“…Rotenone treatment of differentiated SH-SY5Y (dSY5Y) cells increased LRKK2 levels and kinase activity, including phospho-S935-LRRK2, phospho-S1292-LRRK2, and the phospho-moesin/moesin ratio, in a dose-dependent manner. Neuronal toxicity and the elevation of cleaved poly (ADP-ribose) polymerase, NCL, and Hsp70 were increased by rotenone. …”
Publicado 2018
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101232AB025. The effects and mechanisms of magnetic nanomaterials in prostate cancer diagnosis and therapypor Zhang, Li“…Fe(3)O(4) NCs could induce the medium temperature elevated in a time- and dose-dependent manner under 808 nm NIR irradiation. Besides, Fe(3)O(4) NCs could induce complete autophagic flux in PC3 cells, which effect could be inhibited by 3-MA or CQ administration. …”
Publicado 2018
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101233por Bi, Yi-ming, Wu, Yu-ting, Chen, Ling, Tan, Zhang-bin, Fan, Hui-jie, Xie, Ling-peng, Zhang, Wen-tong, Chen, Hong-mei, Li, Jun, Liu, Bin, Zhou, Ying-chun“…RESULTS: The results showed that TBHP resulted in an increase in cardiomyocyte apoptosis, whereas 3,5-diCQA treatment protected cells from TBHP-induced apoptosis in a dose-dependent manner. Moreover, 3,5-diCQA decreased expressions of Bax and caspase-3 but increased the phosphorylation levels of PI3K and Akt in TBHP-treated cells, which are the key molecules mediating cell survival, whereas phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphorylation was unchanged. …”
Publicado 2018
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101234“…Moreover, matrix metalloproteinase (MMP)-9 activity was modulated by caspase-1, in a P2Y(2)R-dependent manner in the MDA-MB-231 and RT-R-MDA-MB-231 cells. …”
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101235por Dietrich, Georg, Krebs, Jonathan, Fette, Georg, Ertl, Maximilian, Kaspar, Mathias, Störk, Stefan, Puppe, Frank“…Objectives: The goal of our work is to provide an ad hoc IE service that allows users to query text data ad hoc in a manner similar to querying structured data in a CDW. …”
Publicado 2018
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101236por Fradet, Laurent, Temmar, Rabia, Couture, Frédéric, Belzile, Mathieu, Fortier, Pierre-Hugues, Day, Robert“…PACE4 isoforms have also been suggested to play a role in other cancers, including thyroid cancer, but have never been investigated in a detailed manner. Our objective is to compare the histochemical distribution of the two major PACE4 isoforms in benign and malignant thyroid nodules, in order to determine their potential usefulness as discriminatory biomarkers. …”
Publicado 2018
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101237“…Over 2000 differentially expressed genes (DEGs) were determined by normalized ratio of Reads Per Kilobase of transcript per million mapped reads (RPKM) among the transgenic and non-transgenic fish in a tissue specific manner, and there were 82 DEGs in common among the three tissues. …”
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101238por Varga, Karolina, Hollósi, Anna, Pászty, Katalin, Hegedűs, Luca, Szakács, Gergely, Tímár, József, Papp, Béla, Enyedi, Ágnes, Padányi, Rita“…CONCLUSIONS: Our results suggest that the expression of Ca(2+) pumps is highly regulated in breast cancer cells in a subtype specific manner. Our results suggest that hormonal imbalances, epigenetic modifications and impaired protein trafficking could interfere with the expression and cellular function of PMCA4b in the course of breast cancer progression. …”
Publicado 2018
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101239“…We found that in AGS and SGC7901 cell, BBR inhibited cell proliferation in a time- and dose-dependent manner through downregulating C-myc. BBR also induced G(0)-G(1) phase arrest with the decreased expression of cyclin D1. …”
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101240por Stavenschi, Elena, Corrigan, Michele A., Johnson, Gillian P., Riffault, Mathieu, Hoey, David A.“…RESULTS: CHP elicited a positive, but variable, early osteogenic response in hBMSCs in a magnitude- and frequency-dependent manner, that is gene specific. COX2 expression elicited magnitude-dependent effects which were not present for RUNX2 or OPN mRNA expression. …”
Publicado 2018
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