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  1. 101361
    “…Oral administration of MPP leaf extract (200 mg/kg) significantly reduced serum uric acid level in hyperuricemic rats in time-dependent manner to the baseline level and it was as effective as allopurinol (5 mg/kg). …”
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    Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout
  2. 101362
    por Jackman, Joshua A., Cho, Nam-Joon
    Publicado 2012
    “…Specifically, its N-terminal amphipathic, α-helix (AH) can rupture lipid vesicles in a size-dependent manner. While this activity has a number of exciting biotechnology and biomedical applications, arguably the most promising one is in antiviral medicine. …”
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    Model Membrane Platforms for Biomedicine: Case Study on Antiviral Drug Development
  3. 101363
    “…CONCLUSION: The PNA-(RXR)(4)XB targeting the domain I of IRES suppressed extracellular levels of HPeV3 RNA in an in vitro model in a dose-dependent manner. Thus, PNA treatment may be a therapeutic candidate for HPeV3-infected patients. …”
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    Antiviral Activity of Peptide Nucleic Acid against Human Parechovirus Type 3
  4. 101364
    “…Although A. fumigatus is the main etiological agent of Aspergillus species-related infections, other species, such as A. nidulans, are prevalent in a condition-specific manner. A. nidulans is a predominant infective agent in patients suffering from chronic granulomatous disease (CGD). …”
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    Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans
  5. 101365
    “…Hepatocyte mono-cultures and hepatocyte—nonparenchymal cell co-cultures responded to heat stress in a similar manner, but the higher metabolic rate of co-cultured cells may have contributed to a better capability of inflamed liver cells for accommodation to stress conditions. …”
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    Effects of Acute Heat Stress on a Newly Established Chicken Hepatocyte—Nonparenchymal Cell Co-Culture Model
  6. 101366
    “…Cameroon is a lower-middle-income country, and based on data from high- and low-income countries, we hypothesized that more than 50% of participants would be using the checklist (penetration) in the correct manner (fidelity) 4 months postintervention. METHODS: A collaboration of 3 stakeholders (Ministry of Health, academic institution, and nongovernmental organization) used a prospective observational design. …”
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    Using the Knowledge to Action Framework to Describe a Nationwide Implementation of the WHO Surgical Safety Checklist in Cameroon
  7. 101367
    “…In avian influenza virus-infected patients, the host immune system is activated in an uncontrolled manner and is unable to control infection in a timely fashion. …”
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    Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue-Resident Memory T Cells during H5N1 Infection
  8. 101368
    “…Furthermore, the expression of IDO1 was induced by IFNγ in a dose‐dependent manner in PSCC cells. CONCLUSIONS: IFNγ‐induced IDO1 plays a crucial role in immunoediting and immunosuppression in PSCC. …”
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    Up‐regulation of indoleamine 2,3‐dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients
  9. 101369
    por Salganik, Matthew J., Lundberg, Ian, Kindel, Alexander T., Ahearn, Caitlin E., Al-Ghoneim, Khaled, Almaatouq, Abdullah, Altschul, Drew M., Brand, Jennie E., Carnegie, Nicole Bohme, Compton, Ryan James, Datta, Debanjan, Davidson, Thomas, Filippova, Anna, Gilroy, Connor, Goode, Brian J., Jahani, Eaman, Kashyap, Ridhi, Kirchner, Antje, McKay, Stephen, Morgan, Allison C., Pentland, Alex, Polimis, Kivan, Raes, Louis, Rigobon, Daniel E., Roberts, Claudia V., Stanescu, Diana M., Suhara, Yoshihiko, Usmani, Adaner, Wang, Erik H., Adem, Muna, Alhajri, Abdulla, AlShebli, Bedoor, Amin, Redwane, Amos, Ryan B., Argyle, Lisa P., Baer-Bositis, Livia, Büchi, Moritz, Chung, Bo-Ryehn, Eggert, William, Faletto, Gregory, Fan, Zhilin, Freese, Jeremy, Gadgil, Tejomay, Gagné, Josh, Gao, Yue, Halpern-Manners, Andrew, Hashim, Sonia P., Hausen, Sonia, He, Guanhua, Higuera, Kimberly, Hogan, Bernie, Horwitz, Ilana M., Hummel, Lisa M., Jain, Naman, Jin, Kun, Jurgens, David, Kaminski, Patrick, Karapetyan, Areg, Kim, E. H., Leizman, Ben, Liu, Naijia, Möser, Malte, Mack, Andrew E., Mahajan, Mayank, Mandell, Noah, Marahrens, Helge, Mercado-Garcia, Diana, Mocz, Viola, Mueller-Gastell, Katariina, Musse, Ahmed, Niu, Qiankun, Nowak, William, Omidvar, Hamidreza, Or, Andrew, Ouyang, Karen, Pinto, Katy M., Porter, Ethan, Porter, Kristin E., Qian, Crystal, Rauf, Tamkinat, Sargsyan, Anahit, Schaffner, Thomas, Schnabel, Landon, Schonfeld, Bryan, Sender, Ben, Tang, Jonathan D., Tsurkov, Emma, van Loon, Austin, Varol, Onur, Wang, Xiafei, Wang, Zhi, Wang, Julia, Wang, Flora, Weissman, Samantha, Whitaker, Kirstie, Wolters, Maria K., Woon, Wei Lee, Wu, James, Wu, Catherine, Yang, Kengran, Yin, Jingwen, Zhao, Bingyu, Zhu, Chenyun, Brooks-Gunn, Jeanne, Engelhardt, Barbara E., Hardt, Moritz, Knox, Dean, Levy, Karen, Narayanan, Arvind, Stewart, Brandon M., Watts, Duncan J., McLanahan, Sara
    Publicado 2020
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    Measuring the predictability of life outcomes with a scientific mass collaboration
  10. 101370
    por Sohail, Ayesha, Nutini, Alessandro
    Publicado 2020
    “…CONCLUSIONS: From the analysis, I is concluded that control strategy via delay is a promising technique and the role of Hill function formalism in control strategies can be better interpreted in an inexpensive manner with the aid of a theoretical framework.…”
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    Forecasting the timeframe of 2019-nCoV and human cells interaction with reverse engineering
  11. 101371
    “…We hypothesized that mutations in previously identified genes or genes from the same pathways are the cause of POI in a recessive or dominant manner. Subjects included 294 women diagnosed with POI (amenorrhea with an elevated FSH level). …”
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    OR31-06 Candidate Gene Variants in a Large Cohort of Women with Primary Ovarian Insufficiency
  12. 101372
    “…Neurofibromatosis type 1 (NF1) is an inheritable in an autosomal dominant manner tumor predisposition syndrome and is caused by loss-of-function mutations in the tumor suppressor NF1 gene (neurofibromin 1). …”
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    MON-072 A 2 -Year Old Girl with Turner Syndrome and Neurofibromatosis Type 1
  13. 101373
    “…Chronic stress in adult rats blunts HPT axis response to voluntary exercise in a sex-dependent manner (Front Endocrinol 10(418):1-13, 2019). As adolescents show sex-dependent responses to stress, we sought to evaluate the effect of chronic stress at this period in the response of HPT axis to voluntary exercise in adulthood. …”
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    SAT-451 Chronic Stress During Adolescence of Rats Shows Sex Dimorphism in the Thyroid Axis Response to Voluntary Exercise in Adulthood
  14. 101374
    “…Conclusion PPL may present in a similar manner as pituitary apoplexy. Absence of typical imaging characteristics of apoplexy in patients with rapid symptom progression and CN involvement should alert clinicians to consider alternative diagnosis including aggressive neoplastic, inflammatory and infective lesions.…”
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    MON-237 Primary Pituitary Lymphoma - an Unusual Guest in the Sella!
  15. 101375
    “…As many of these interventions may be discussed in early adolescence, it is of the utmost importance that information is presented in an understandable and developmentally appropriate manner.…”
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    MON-075 Autonomy and Self-Determination in a Patient with XY Gonadal Dysgenesis
  16. 101376
    “…This work is part of on-going innovation to enhance the pick-up rate for these cases whilst addressing the increased endocrine workload in a cost-effective manner. 1. Barzon L, Sonino N, Fallo F, Palu G, Boscaro M. …”
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    SAT-174 Adrenal Incidentalomas: Prevalence and Referral Patterns in a UK University Hospital Using Real-Life Data
  17. 101377
    “…The expression of hepatic Cd36, Cidea, Cidec, and Fabp4 was increased by TZD in a Pparg-dependent manner in HF-fed mice. Altogether, this data suggest that hepatocyte Pparg expression may offset the antisteatogenic actions of TZD in mice with severe obesity. …”
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    OR14-05 Hepatocyte Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Offsets the Anti-Steatogenic Effects of Thiazolidinediones in Obese Male Mice
  18. 101378
    “…Preliminary results suggest that exposure canine osteosarcoma (COS) cells to conditioned media from KTaR-1 cells leads to increases in sp7 expression in an E2-dependent manner, such that 24h E2-deprivation of these neurons stimulates secretion of osteogenic factors. …”
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    SUN-263 In Vitro Modeling of Brain-Bone Communication: Factors Secreted from Immortalized Female Kisspeptin Neurons Modulate Gene Expression in Osteoblasts
  19. 101379
    “…Recent reports have shown that PPARδ activation is tuned, in part, through an interaction with fatty acid binding protein 5 (FABP5) in a polyunsaturated Fatty acids (PUFAs) dependent manner. This enhancement is thought to occur due to ligand transfer, however, FABP5 only binds a subset of reported PPARδ ligands. …”
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    SAT-LB124 Phosphatidylcholine Transfer Protein Interacts With PPARδ to Modulate Activity
  20. 101380
    “…[Conclusion] The changes in adiponectin and leptin secretion by pioglitazone are via PPARγ activation, while those by telmisartan and irbesartan may occur in PPARγ-independent manner.…”
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    MON-596 Effects of Angiotensin Type 1 Receptor Blockers (ARBs) on the Expression and Secretion of Adiponectin and Leptin in Human White Adipocytes
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