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  1. 101621
    “…To trace pre-existing Osx(+) and DMP1(+) lineage cells, tamoxifen (TMX: 100 mg/kg gavage) was given in a pulse manner (three doses, 4 weeks before injury), while to label pre-existing and newly-derived lineage Osx(+) and DMP1(+) cells, TMX was first given 2 weeks before injury and continuously (twice weekly) throughout healing. …”
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    Postnatal Osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury
  2. 101622
    “…These findings suggest that these services may have the greatest impact on reducing reincarceration risk when they are available in a timely manner in the days and weeks immediately following release.…”
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    Association of Mental Health Services Access and Reincarceration Among Adults Released From Prison in British Columbia, Canada
  3. 101623
    “…Cell viability assays documented that all melanoma cells were affected by low HPF concentrations (EC50% 2–4 µM) in a time-dependent manner. A Br-deoxy-uridine incorporation assay attested a significant reduction of cell proliferation accompanied by decreased expression of cyclin D1 and A2, CDK4 and of the Rb protein phosphorylation, as assessed by immunoblots. …”
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    Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism
  4. 101624
    “…With the reduction in TG and oxidized products in LDL and HDL, lipoproteins could have more anti-atherogenic properties through regular exercise in an intensity-dependent manner.…”
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    Enhancement of High-Density Lipoprotein (HDL) Quantity and Quality by Regular and Habitual Exercise in Middle-Aged Women with Improvements in Lipid and Apolipoprotein Profiles: Larger Particle Size and Higher Antioxidant Ability of HDL
  5. 101625
    “…Regarding the expression of ECM molecules, (1) upon DIF+, significant downregulation or upregulation of Col1 and Fn (3D), or Col4 and 6 (2D and 3D) were observed, and (2) in the presence of IGF-1 and/or M22, the mRNA expression of Col4 was significantly downregulated by M22 (2D and 3D), but the expression of Col1 was modulated in different manners by monotreatment (upregulation) or the combined treatment (downregulation) (3D). …”
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    Unexpected Crosslinking Effects of a Human Thyroid Stimulating Monoclonal Autoantibody, M22, with IGF1 on Adipogenesis in 3T3L-1 Cells
  6. 101626
    “…A common pathomechanistic pathway of PPCM includes increased oxidative stress and the subsequent generation of a cleaved prolactin fragment (16 kDa PRL), which promotes the onset of heart failure (HF) in a microRNA (miR)‐146a‐dependent manner. Inhibition of prolactin secretion with the dopamine D2 receptor (D2R) agonist bromocriptine combined with standard HF therapy supports cardiac recovery. …”
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    Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy
  7. 101627
    “…Dapagliflozin slowed the migration rate of HFrEF fibroblasts in a dose‐dependent manner and markedly decreased the expression of IL‐1β, IL‐6, MMP3, MMP9, GAL3, and FN1. …”
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    Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction
  8. 101628
    “…Neck imbalance indexes were obtained and measured following a standardized manner. Intra‐class correlation coefficient (ICC) analysis was performed for neck imbalance indexes to determine their intra‐observer and inter‐observer reliability, and correlation tests were performed for neck imbalance indexes with the radiographic parameters mentioned above. …”
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    Assessment of Neck Imbalance in Adolescent Idiopathic Scoliosis Patients: A Cross‐Section Study Based on Body Image of 115 Patients with Main or Double Thoracic Curve
  9. 101629
    “…These OSCs, when administered in a dose-dependent and combinatorial-based manner, can have an enhanced impact on epigenetic alterations, which may lead to the cancer prevention and therapy. …”
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    Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms
  10. 101630
    “…It was concluded that salbutamol showed better results however, spirulina also effectively reduced mild to moderate allergic symptoms in dose‐dependent manner. Nutraceutical and functional foods are considered helpful in mitigating oxidative stress‐mediated health problems. …”
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    Therapeutic efficacy of spirulina against ovalbumin and cigarette smoke‐induced asthma‐specific stress biomarkers in Sprague–Dawley rats
  11. 101631
    “…RESULTS: The training component of the intervention was delivered in a manner that included creating ownership among health managers who became champions for other health care providers; joint training across cadres to have clear roles, responsibilities and division of labour; and generating critical reflections about how gender power dynamics influence women's experience of violence and their health. …”
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    Innovations in implementing a health systems response to violence against women in 3 tertiary hospitals of Maharashtra India: Improving provider capacity and facility readiness
  12. 101632
    “…In addition, BALF2 interacts with the nucleocapsid-associated protein BVRF1, suggesting that BALF2 may be transported into the cytoplasm with nucleocapsids in a nuclear egress complex (NEC)-dependent manner. A group of proteins involved in intracellular transport were identified to interact with BALF2 in a proteomic analysis. …”
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    Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release
  13. 101633
    “…Intra-VMN aromatase siRNA administration decreased baseline aromatase protein expression and tissue estradiol concentrations and either reversed or attenuated the hypoglycemic regulation of these profiles in a VMN segment-specific manner. Aromatase gene repression down-regulated protein biomarkers for gluco-stimulatory (nitric oxide; NO) and -inhibitory (gamma-aminobutyric acid; GABA) neurochemical transmitters. …”
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    Effects of Ventromedial Hypothalamic Nucleus (VMN) Aromatase Gene Knockdown on VMN Glycogen Metabolism and Glucoregulatory Neurotransmission
  14. 101634
    por Li, Fulei, Xue, Xiaofei
    Publicado 2023
    “…Furthermore, a risk-score model, which can be employed as a reliable prognostic factor in an independent manner for individuals suffering from liver cancer, was constructed based on 13 cell senescence-related lncRNAs (MIR99AHG, LINC01224, LINC01138, SLC25A30AS1, AC006369.2, SOCS2AS1, LINC01063, AC006037.2, USP2AS1, FGF14AS2, LINC01116, KIF25AS1, and AC002511.2). …”
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    Identification and Characterization of an Ageing-Associated 13-lncRNA Signature That Predicts Prognosis and Immunotherapy in Hepatocellular Carcinoma
  15. 101635
    “…We re‐analyzed these data in a uniform, coherent manner aiming to resolve and extend past findings. …”
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    Altered gene expression in excitatory neurons is associated with Alzheimer's disease and its higher incidence in women
  16. 101636
    “…Results: CBD and CBGA inhibited peak current amplitude in the low micromolar range in a concentration-dependent manner, while CBG, CBCA and CBC revealed only modest inhibition for this subset of sodium channels. …”
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    Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
  17. 101637
    “…Healthy lifestyle was associated with lower risk of PCC in a dose-dependent manner. Compared with women without any healthy lifestyle factors, those with 5 to 6 had 49% lower risk (RR, 0.51; 95% CI, 0.33-0.78) of PCC. …”
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    Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition
  18. 101638
    “…RESULT(S): FCGBP MS cells exhibited significant loss in MUC2 mucus barrier function as quantified by fluorescent beads penetration through the mucus layer in a temporal manner. FCGBP MS cells exhibited an altered glycomic profile with a notable increase in sialylated glycans as quantified by HPLC-MS. …”
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    A230 A MISSENSE MUTATION IN GOBLET CELL PROTEIN FCGBP ALTERS THE GLYCOMIC PROFILE AND FUNCTION OF THE COLONIC MUCUS BARRIER
  19. 101639
    “…In contrast, virus only begins to accumulate in the KC-non-depleted control minutes after infection in a randomized manner. Preliminary invasion results indicate that in both the KC-depleted and non-depleted animals, virus is most readily detectable in the blood within the first hour following viral administration. …”
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    A241 CHARACTERIZING KUPFFER CELL-VIRUS INTERACTIONS IMMEDIATELY FOLLOWING VIRAL INVASION AND IN ACUTE HEPATITIS IN THE WOODCHUCK HEPATITIS VIRUS MODEL OF HEPATITIS B VIRUS INFECTIONS
  20. 101640
    por Goossens, Willemijn Lutgart
    Publicado 2022
    “…A variety of radioisotopes is produced, depending on the composition of the construction material and the energy of the protons. In this manner, radioactive waste is created. To decide on the proper treatment for specific components, the radioisotopes generated in them must be identified and quantified. …”
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    A compact CZT γ-ray detector for nuclear applications in medicine
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