“…We hypothesize that bound water will be diminished in the cartilage of ACLD knees and, after surgery, will continue to adapt in a manner that reflects altered cartilage loading. This abstract presents initial observations on a cross-section of healthy, ACLD and ACLR knees. …”
Enlace del recurso
Enlace del recurso

“…Importantly, the protein level of p-p38 was downregulated in a concentration-dependent manner in HS-derived fibroblasts with ADSC-CM treatment, which further decreased the expression of p-p38 after the application of its inhibitor, SB203580. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using Kaplan-Meier estimators to investigate time to death/default, we showed a sharp drop in death/default-free survival probability at time zero, yet survival probability decreased in a nearly linear manner after this initial period of high default. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was found that serum concentrations of eltoprazine increased in a dose-proportional manner. Following levodopa challenge, 5 mg eltoprazine caused a significant reduction of l-DOPA-induced dyskinesias on area under the curves of Clinical Dyskinesia Rating Scale [–1.02(1.49); P = 0.004] and Rush Dyskinesia Rating Scale [–0.15(0.23); P = 0.003]; and maximum Clinical Dyskinesia Rating Scale score [–1.14(1.59); P = 0.005]. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Rapid, accurate detection kits need to be developed to help us find and treat NoV-associated diarrhea in clinical settings in a timely manner.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: To recruit around 200 older adults with type 2 diabetes into a community-based lifestyle intervention trial in a timely manner, it is important to ensure that an adequate budget is allocated to recruitment as targeted mail-outs and state/local print media were the most costly but effective strategies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gene and protein expression levels are regulated in cell-ECM interaction dependent manner as well. The rate of unsuccessful clinical trials, based on cell culture research models lacking the ECM microenvironment, indicates the need for alternative models and determines the shift to three-dimensional (3D) laminin rich ECM models, better simulating tissue organization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This will ensure that all users receive the full health benefits from these technological advances, in a manner that protects health information privacy, and that users engage with organizations and providers they trust.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further, higher proportion of respondents from PD was highly satisfied with the current set of provisions and manners of functioning of the sample health units. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Both tanshinone IIA and adriamycin could inhibit the growth of A549, PC9, and HLF cells in a dose- and time-dependent manner, while the proliferative inhibition effect of tanshinone IIA on cells was much weaker than that of adriamycin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All cell lines maintained their spheroid shape, except SHSY-5, which behaved in an unpredictable manner when exposed to toxic concentrations of DXR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, IL-12 enhances IL-7Rα expression in a T-bet independent manner in myelin-specific Th1 cells. Meanwhile, IL-6, the cytokine inducing highly encephalitogenic Th17 differentiation, suppresses PD-1 while upregulating IL-7Rα, skewing IL-7Rα/PD-1 balance towards IL-7Rα, and promoting enhanced effector function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An inducible Cre/loxP technique was used to express a genetically-encoded Ca(2+) biosensor (GCaMP3) in a cell-specific manner. Calcium transients were imaged from the IAS of mice expressing GCaMP3 in ICC (Kit-GCaMP3) and smooth muscle cells (SMC; smMHC-GCaMP3) with an Olympus DSU. …”
Enlace del recurso
Enlace del recurso

“…METHODS: This review was conducted in a similar manner to a systematic review by using a stepwise approach that included (1) a search strategy; (2) eligibility assessment; (3) app selection process through an initial screening of all retrieved apps and full app review of the included apps; (4) data extraction using a predefined set of features considered important or desirable in medication reminder apps; (5) analysis by classifying the apps as basic and advanced medication reminder apps and scoring and ranking them; and (6) a quality assessment by using the Mobile App Rating Scale (MARS), a reliable tool to assess mobile health apps. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…C1q appeared to interact with DC-SIGN or DC-SIGNR in a manner similar to IgG. Mutational analysis using single amino acid substitutions within the globular head modules showed that Tyr(B175) and Lys(B136) were critical for the C1q–DC-SIGN/DC-SIGNR interaction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Prior to use in a prospective manner, the models will undergo extensive evaluation using a variety of techniques such as diagnostic plots, bootstrap analysis and cross-validation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In subsequent in vitro study, the related pathway was blocked by anti-RAGE antibody, NADPH oxidase inhibitor DPI, p38MAPK inhibitor SB203580, and anti-cbfa1 antibody in a step-wise manner to observe changes in calcium deposition and molecular signals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SUMMARY ANSWER: Many combinations of numerator and denominator are in use, and are often employed in a manner that compromises the validity of the study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The cell viabilities of the Wog-MNPs-Fe(3)O(4) group (28.64–68.36%) were significantly lower than those of the wogonin group (35.53–97.28%) in a dose-dependent manner in 48 h (P < 0.001). The apoptotic rate of K562/A02 cells was significantly improved in 50 μmol/L Wog-MNPs-Fe(3)O(4) group (34.28%) compared with that in 50 μmol/L wogonin group (23.46%; P < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso