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101861por Safya, Hanaa, Mellouk, Amine, Legrand, Julie, Le Gall, Sylvain M., Benbijja, Mohcine, Kanellopoulos-Langevin, Colette, Kanellopoulos, Jean M., Bobé, Pierre“…Contrary to common assumption, P2X7R-mediated cellular activities in mouse Tconvs are not triggered in an all-or-none manner, but depend on their stage of activation/differentiation. …”
Publicado 2018
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101862por Zhao, Lu, Shi, Mengchen, Zhou, Lina, Sun, Hengchang, Zhang, Xiaona, He, Lei, Tang, Zeli, Wang, Caiqin, Wu, Yinjuan, Chen, Tingjin, Shang, Mei, Zhou, Xinyi, Lin, Zhipeng, Li, Xuerong, Yu, Xinbing, Huang, Yan“…IL-10 level increased in a time-dependent manner in LPS-treated BMDCs after incubation with CsTPs. …”
Publicado 2018
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101863por Dyck, Scott, Kataria, Hardeep, Alizadeh, Arsalan, Santhosh, Kallivalappil T., Lang, Bradley, Silver, Jerry, Karimi-Abdolrezaee, Soheila“…We delivered ILP and ISP treatment intrathecally to the injured spinal cord in a sustainable manner by osmotic mini-pumps for various time-points post-SCI. …”
Publicado 2018
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101864por Wang, Qian, Zang, Wenhua, Han, Li, Yang, Lei, Ye, Songshan, Ouyang, Jingfeng, Zhang, Chaoyun, Bi, Yuefeng, Zhang, Cuiyue, Bian, Hua“…CONCLUSION: This present study demonstrates that WYHZTL formula has anti-fibrosis effect in Bleomycin-induced SSc mouse model in a dosage-dependent manner, and the molecular mechanism may be related to the inhibition of Wnt/β-catenin signaling pathway. …”
Publicado 2018
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101865por Thomas, Elizabeth, Rossell, Susan, Tan, Eric, Carruthers, Sean, Sumner, Philip, Bozaoglu, Kiymet, Gurvich, Caroline“…Schizotypy is considered a suitable model for investigating schizophrenia as it mirrors the symptoms, albeit in a more subtle manner. As saccadic deficits are a cognitive hallmark of schizophrenia, it is believed that saccadic deficit may be associated with higher schizotypy. …”
Publicado 2018
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101866“…DISCUSSION: In summary, our results show that alpha7 nAChR positive modulators can affect midbrain dopaminergic neuronal activity in vivo in a state-dependent manner. Interestingly, alpha7 nAChR agonists counterbalanced the hyperdopaminergic state of MAM rats and this effect is partially mediated by their action in the vHipp. …”
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101867por Hietala, Jarmo“…The reduced CB1R in patients was also state-dependent as [18F]-FMPEP DVt correlated negatively with psychotic symptoms (BPRS) in a highly significant manner. DISCUSSION: Epidemiological studies have convincingly shown that cannabis use is associated with an increased risk of both psychotic symptoms and schizophrenia-like psychoses. …”
Publicado 2018
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101868por Das, Tushar, Dempster, Kara, Mackinley, Michael, Jeon, Peter, Gati, Joe, Theberge, Jean, Khan, Ali, Palaniyappan, Lena“…METHODS: We used ultra-high field (7 Tesla) MRI in 28 patients with FEP (satisfying criterion A of DSM-5 schizophrenia) and 18 controls, to estimate grey matter volume in a voxelwise manner. FEP and controls were matched for age, sex and parental socioeconomic status. …”
Publicado 2018
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101869por Chiramberro, Marcelo, Kieseppä, Tuula, Wegelius, Asko, Töhönen, Tuomo, Ilvonen, Jenna, Väisänen, Heli, Sarkkinen, Katja, Tikkala, Jenni, Leiponen, Marita, Ruppa, Markku, Hyytiäinen, Matias, Hynninen-Sundelin, Ira, Anttonen, Esa“…The doctor, nurses, a psychologist and an occupational therapist participated the group with different combinations and in a nonhierarchical manner. Psychoeducation was used to increase the knowledge and coping with the disorder. …”
Publicado 2018
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101870por Kinsella, Sinéad, Fichtner, Michael, Watters, Orla, König, Hans-Georg, Prehn, Jochen H. M.“…Furthermore, Smad6-facilitated recruitment of the de-ubiquitinase A20 to E3-ligases occurred in a bid-dependent manner. CONCLUSIONS: This study demonstrates that Bid promotes E3 ubiquitin ligase-mediated signaling downstream of TLR3 and TLR4 and provides further evidence for the potential of Bid inhibition as a therapeutic for the attenuation of the robust pro-inflammatory response culminating in TLR activation. …”
Publicado 2018
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101871por Facci, Laura, Barbierato, Massimo, Zusso, Morena, Skaper, Stephen D., Giusti, Pietro“…RESULTS: Apo-SAA stimulated, in a time-dependent manner, the expression of NLRP3, IL-1β, and TNF-α in cortical microglia, and produced a concentration-dependent increase in the intracellular content of IL-1β in these cells. …”
Publicado 2018
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101872“…NDRG1 mRNA was elevated in a dose-dependent manner of LXA4, whereas BOC-2 antagonized NDRG1 expression induced by LXA4. …”
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101873por Mertens, Tinne C. J., Hanmandlu, Ankit, Tu, Ly, Phan, Carole, Collum, Scott D., Chen, Ning-Yuan, Weng, Tingting, Davies, Jonathan, Liu, Chen, Eltzschig, Holger K., Jyothula, Soma S. K., Rajagopal, Keshava, Xia, Yang, Guha, Ashrith, Bruckner, Brian A., Blackburn, Michael R., Guignabert, Christophe, Karmouty-Quintana, Harry“…Increased expression of IL-6, HAS2 and Tgm2 was observed in PASMC in an ADORA2B-dependent manner. These mediators were also reduced in ADORA2B(f/f)- Tagln(cre) mice exposed to HX-SU or BLM. …”
Publicado 2018
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101874por He, Junyu, Christakos, George, Wu, Jiaping, Cazelles, Bernard, Qian, Quan, Mu, Di, Wang, Yong, Yin, Wenwu, Zhang, Wenyi“…Lastly, another finding of this work is that geographic factors affect the climate-HFRS association in an interrelated manner through local climate or by means of HFRS infections. …”
Publicado 2018
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101875por Marjonen, Heidi, Auvinen, Pauliina, Kahila, Hanna, Tšuiko, Olga, Kõks, Sulev, Tiirats, Airi, Viltrop, Triin, Tuuri, Timo, Söderström-Anttila, Viveca, Suikkari, Anne-Maria, Salumets, Andres, Tiitinen, Aila, Kaminen-Ahola, Nina“…CONCLUSIONS: The observed DNA methylation changes together with the phenotypic findings suggest that rs10732516 polymorphism associates with the effects of ART in a parent-of-origin manner. Therefore, this polymorphism should be considered when the effects of environmental factors on embryonic development are studied. …”
Publicado 2018
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101876por Conti, Sefora, Vexler, Akiva, Edry-Botzer, Liat, Kalich-Philosoph, Lital, Corn, Benjamin W., Shtraus, Natan, Meir, Yaron, Hagoel, Lior, Shtabsky, Alexander, Marmor, Sylvia, Earon, Gideon, Lev-Ari, Shahar“…AKBA treatment was found to inhibit the survival of all four tested cell lines in a dose dependent manner. The combined treatment resulted in a more significant inhibitory effect compared to the effect of treatment with radiation alone. …”
Publicado 2018
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101877por Ru, Jiang-ying, Chen, Li-xin, Hu, Fang-yong, Shi, Dai, Xu, Rao, Du, Jian-wei, Niu, Yun-fei“…A better understanding of prognostic factors could potentially reduce the risk of re-nonunion happening and allow patients to maximize their recovery in the most expeditious manner. Our study aims to identify risk factors in the development of re-nonunion after primary revision inclusive of exchanging reamed nailing (ERN) and augmentative compression plating (ACP) with IMN in situ for femoral shaft nonunion subsequent to failed IMN. …”
Publicado 2018
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101878por Zelmer, Jennifer, van Hoof, Krystle, Notarianni, MaryAnn, van Mierlo, Trevor, Schellenberg, Megan, Tannenbaum, Cara“…This study describes an attempt by Canadian stakeholders to develop an e-mental health assessment framework that responds to the unique needs of people living in Canada in an evidence-based manner. OBJECTIVE: The objective of our study was to achieve consensus from a broad group of Canadian stakeholders on guiding principles and criteria for a framework to assess e-mental health apps in Canada. …”
Publicado 2018
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101879“…It downregulated the phosphorylation of NF-κB (p65), IκBα, and IKKα/β and restored the degradation of IκBα, and attenuated the expression of Akt, JNK, ERK, and p38 MAPKs phosphorylation in a dose-dependent manner. P. amarus extract also downregulated the expression of upstream signaling molecules, TLR4 and MyD88, which play major role in activation of NF-κB, MAPK and PI3K-Akt signaling pathways. …”
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101880por Li, Bingbing, Zhu, Yuling, Sun, Qing, Yu, Chunfang, Chen, Lian, Tian, Yali, Yan, Jie“…The results indicated that DCA inhibited human PASMC proliferation in a dose-dependent manner. DCA at 10 mM promoted apoptosis and the upregulation of activated caspase-3 in PASMCs pre-treated with 20 ng/ml PDGF-homeodimer BB (BB). …”
Publicado 2018
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