“…Notably, RvD1 impaired CAF-derived COMP in a paracrine manner by targeting FPR2/ROS/FOXM1 signaling to ultimately abrogate FOXM1 recruitment to the COMP promoter. …”
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“…Compared with traditional methods for coding receipt data, MTurk can produce excellent-quality data in a lower-cost, more time-efficient manner.…”
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“…CONCLUSION: The expansion of universal health coverage in Haiti is evolving in a ‘pro-rich’ manner. Realizing Haiti’s right to health will require a course-correction supported by national policies that protect the poor wealth quintiles from catastrophic health expenditures. …”
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“…Testosterone regulates erythropoiesis, increasing hemoglobin and hematocrit in a dose dependent manner. There is currently no data on the effect of TT on HbA1c accuracy in transmen with diabetes. …”
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“…While obesity is considered to be protective against fracture, existing literature suggests that obesity affects fracture risk in a site-specific manner. In particular, higher risk of fracture has been observed at the lower leg/ankle and upper arm/shoulder, while lower risk of fracture has been observed at the hip, wrist, and spine. …”
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“…We hypothesized that in utero HIV/ART exposure may condition fetal development in a manner that predisposes to obesity and reactive airway disease (RAD) later in life. …”
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“…Tilt table results and resting PR intervals were taken from their electronic medical records and the pts were then categorized in the same manner as the first data set. Results: In the second group of 447 pts (n=447), 28.6% (n= 128) are categorized as having orthostatic intolerance, 51.6% (n=231) are categorized as mild POTS, and 19.6% (n=88) are categorized as severe POTS. …”
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“…Furthermore, cinacalcet rectifies the hypercalcemia of Gna11 null mice, thus indicating that this CaSR-targeted compound may modulate parathyroid gland function in a Gα(11)-independent manner.…”
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“…In related studies, we have observed that AZP-3404, both alone and in an additive manner with insulin, stimulates glucose transport in mouse C2C12 differentiated myotubes through activation of AMP-activated protein kinase (AMPK). …”
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“…Finally, we showed that T3 exposure induces a 50% increase in 11βHSD2 mRNA levels in KC3AC1 cells, in a dose-dependent and time-dependent manner (as early as 6 h) (p<0.01). This induction was abrogated by Actinomycin D or DRB, two inhibitors of transcription, underlining a transcriptional regulatory mechanism. …”
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“…BACKGROUND: Glucagon-like peptide-1 (GLP-1) functions to increase insulin production in a glucose-dependent manner. Endogenous GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase 4 (DPP4), and GLP-1 receptor agonists and DPP4 inhibitors (DPP4Is) are now used in the treatment of diabetes. …”
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“…IME inhibited the proliferation and migration of MG63 and U2OS cells in a concentration-dependent manner and decreased the expression of ITGAV. MTT and Transwell assays showed that 25 μmol/L IME and 5 μmol/L DDP exhibited similar inhibitory effects on the proliferation and migration of OS cells. …”
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“…Our results demonstrated that RCAN1.4 over-expression alleviates, whereas its knockdown exacerbates, TGF-β1-induced liver fibrosis in vitro in a CaN/NFAT3 signaling-dependent manner. Conclusions: RCAN1.4 could alleviate liver fibrosis through inhibition of CaN/NFAT3 signaling, and the anti-fibrosis function of RCAN1.4 could be blocked by DNA methylation mediated by DNMT1 and DNMT3b. …”
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“…The signal of the PPARE reporter increased in a dose-dependent manner with rosiglitazone (PPARg agonist) in KAIMRC1, MCF7, and MDA-MB231 when the proliferator-activated receptors gamma (PPARg)/RXRa receptors were cotransfected. …”
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“…RESULTS: In CCH rats, treatment with 40 and 80 mg/kg NBP decreased the Evans blue content in brain tissue (9.0 ± 0.9 μg/g vs. 12.3 ± 1.9 μg/g, P = 0.005; 6.7 ± 0.6 μg/g vs. 12.3 ± 1.9 μg/g, P < 0.01), increased the expression of claudin-5 (0.79 ± 0.08 vs. 0.41 ± 0.06, P < 0.01; 0.97 ± 0.07 vs. 0.41 ± 0.06, P < 0.01), and elevated the ZO-1 protein level (P < 0.05) in brain microvascular segments in a dose-dependent manner in comparison with the corresponding values in the model group. …”
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“…By clustering six receptor chains in a spatially well-defined manner, HERA-GITRL induces potent agonistic activity without being dependent on additional FcγR-mediated crosslinking. …”
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“…It is unclear, if neuro-axonal damage occurs only in an attack-dependent manner or also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes in eyes without new optic neuritis (ON) in MOG-IgG-seropositive patients. …”
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“…In these first main-group metal–prehnitene complexes, the distorted η(6) arene π-bonding to the tin atoms of the Sn(2)Cl(2) (2+) moieties in the centre of [{1,2,3,4-(CH(3))(4)C(6)H(2)}(2)Sn(2)Cl(2)][MCl(4)](2) repeating units (site symmetry [Image: see text]) is characterized by: (i) a significant ring slippage of ca 0.4 Å indicated by the dispersion of Sn—C distances [1: 2.881 (2)–3.216 (2) Å; 2: 2.891 (3)–3.214 (3) Å]; (ii) the non-methyl-substituted arene C atoms positioned closest to the Sn(II) central atom; (iii) a pronounced tilt of the plane of the arene ligand against the plane of the central (Sn(2)Cl(2))(2+) four-membered ring species [1: 15.59 (11)°, 2: 15.69 (9)°]; (iv) metal–arene bonding of medium strength as illustrated by application of the bond-valence method in an indirect manner, defining the π-arene bonding inter­action of the Sn(II) central atoms as s(Sn(II)—arene) = 2 − Σs(Sn(II)—Cl), that gives s(Sn(II)—arene) = 0.37 and 0.38 valence units for the aluminate and the gallate, respectively, indicating that comparatively strong main-group metal–arene bonding is present and in line with the expectation that [AlCl(4)](−) is the slightly weaker coordinating anion as compared to [GaCl(4)](−).…”
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“…Bicarbonate levels increase calcium accumulation in rat aortic wall in a dose-response manner (pH = 7.4). Moreover, citrate prevents calcium accumulation, with a mean inhibitor concentration (IC(50)) value of 733 µmol/L. …”
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“…These results clearly indicated that exogenous application of MeJA with T. harzianum inducing JA- and/or SA-dependent defense signaling after pathogen challenge may increase the resistance to spot blotch by stimulating enzymatic activities and the accumulation of phenolic compounds in a cooperative manner. This study apparently provides the evidence of biochemical cross-talk and physiological responses in wheat following MeJA and biocontrol agent treatment during the bio-trophic infection.…”
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