“…In both primary fibroblast lines, R1881 treatment increased AR levels in a dose dependent manner, indicating that the treatment was effective. …”
Enlace del recurso
Enlace del recurso

“…Because of persistent ketonemia with low normal BG levels, patient was questioning about her dietary habits and revealed to maintain severe carbohydrate-restricted pre-conception eating manners. After repeated consultations by specialists for eating disorder, patient agreed to increase her carbohydrate intake to 120 gr per day. …”
Enlace del recurso
Enlace del recurso

“…The unconjugated antagonist inhibited the proliferation of Ba/F3-GHR cells in a dose-dependent manner with a half maximal inhibitory concentration (IC(50)) of 10.1 ± 2.5 nM. …”
Enlace del recurso
Enlace del recurso

“…As anticipated, the gel cross-linked with l-Pep-NC was degraded in 7–45 days upon exposure to metalloproteases in a concentration-dependent manner, while the gel cross-linked with the d-Pep-NC remained intact even after 2 months. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on this, the chronological age can be predicted by the epigenetic clock in a highly consistent manner. The aims of this research were to determine the effect chronological and biological age on current SI and secondly, to determine the effect of the variation of cellular blood cell composition on current SI. …”
Enlace del recurso
Enlace del recurso

“…We propose that sustaining and switching attention may represent two poles of irregularities across the autism and schizotypal spectra, which appear to converge in a compensatory manner in the comorbid group. Our findings highlight the importance of investigating the concurrent effect of ASD and SPD at both the symptom and diagnostic levels, and the potential benefit of this research approach to understanding the underlying mechanisms of seemingly overlapping phenotypes.…”
Enlace del recurso
Enlace del recurso

“…The “expressive deficits” factor was defined as the sum of the six following items of the PANSS: N1 (blunted affect), N3 (poor rapport), N6 (lack of spontaneity and flow of conversation), G5 (mannerisms and posturing), G7 (motor retardation), G13 (disturbance of volition). …”
Enlace del recurso
Enlace del recurso

“…On day 0, pens within each block were randomly assigned to receive one of the three treatments, in a manner that pens did not receive the same treatment in both periods (total n = 6 pens per treatment). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Participants received a smartphone-based music intervention and listened to the music in either a supervised (research assistant–delivered music session 3 times during their stay) or unsupervised manner (music used ad lib by participant). The app collected premusic and postmusic pain and anxiety scores, and participants provided qualitative feedback regarding acceptability of operating the music intervention. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These findings provide evidence for the feasibility of using Facebook as an intervention delivery tool in a manner that can be rolled out into practical settings.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Microbiome alpha-diversity increased as a CFPE developed and then decreased during treatment in a manner corresponding to the reduction in the log ratio of anaerobic bacteria to classic pathogens. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the future, the PHR platform could be utilized for the purpose of precision and individual medicine in a cross-country manner because of the platform’s provision of a secure and efficient PHR sharing and management architecture, making it a reasonable base for future data collection sources and the data analytics needed for precision medicine.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, TM5441 treatment of WT mice pre-fed the HFD resulted in a marked suppression of body weight gain in a PAI-1-dependent manner (HFD-WT-Control mice 37.6 ± 1.07 g vs HFD-WT-TM5441 mice 33.8 ± 0.97 g, P = 0.017). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On co-treatment with TSH, MSq1 suppressed TSH-induced proliferation of thyrocytes in a dose-dependent manner but lacked the intrinsic ability to influence basal thyrocyte proliferation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Spearman correlation analysis showed the positive correlation of MMP-2 and MMP-9 protein expression levels with JAK2V617F mutation (r=0.526, P=0.001; r=0.543, P=0.001). ②The proliferation of HEL cells was inhibited by different concentrations of ruxolitinib in time and dose dependent manner. ③Cell migration test showed the number of cells leaked to the low chamber in MPN patients bone marrow cells and HEL cells treated with 5 nmol/L of ruxolitinib group were significantly lower than that without ruxolitinib treatment after 24 h [(154.7±27.5) vs (320.3±67.3), t=13.47, P<0.05; (70.7±10.5) vs (135.3±16.7), t=13.89, P<0.05]. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Opioids bind to TLR4, in a manner parallel to LPS, activating TLR4 signaling, which leads to nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) expression and the production of the pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In vitro, IL-6/IL-6R significantly promoted the production of B cell activating factor, IL-7, IL-12, and IL-23 in AAFs in a dose-dependent manner. This effect was partially blocked by JAK1, JAK2, STAT3, and Akt inhibitors, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: β-mannanase can hydrolyze β-1,4 glycosidic bond of mannan by the manner of endoglycosidase to generate mannan-oligosaccharides. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Onpattro, Hensify and Vyxeos), have demonstrated that the nanomedicine field is concretely able to design products that overcome critical barriers in conventional medicine in a unique manner, but also to deliver within the cells new drug-free therapeutic effects by using pure physical modes of action, and therefore make a difference in patients lives. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTERVENTIONS: Standard care treatment with 8 applications of either CAP generated from argon gas in an atmospheric pressure plasma jet or 8 applications of placebo treatment in a patient-blinded manner. MAIN OUTCOMES AND MEASURES: Primary end points were reduction in wound size, clinical infection, and microbial load compared with treatment start. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso