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102021“…Moreover, it is impervious to arguments and evidences, in the same manner as delusion. However, it differs from it by at least two major characteristics: it is shareable and socializing; it gives rise to a consistent attitude.…”
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102022“…Joy had quality contents with both utilitarian and hedonic value, its male and female users could be encouraged to use medical chatbots in a convenient, easy-to-use, and enjoyable manner. To boost their continued usage intention for Dr. …”
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102023“…These center around an intervention’s ability to incorporate interactive, user-centered features; direct a descriptive and structured recovery; enable customizable, patient-controlled settings; and deliver both general and specific surgical advice in a timely manner. Interventions that are initiated preoperatively and continued postoperatively were perceived as beneficial. …”
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102024por Yalikong, Ayimukedisi, Li, Xu-Quan, Zhou, Ping-Hong, Qi, Zhi-Peng, Li, Bing, Cai, Shi-Lun, Zhong, Yun-Shi“…Comparing with free TPL treatment group, TPLNP developed stranger colon cancer-killing efficiency in a dose- and time-dependent manner detected with CCK8 method; achieved good in vitro colon cancer targeting detected with flow cytometry and immunofluorescence experiments; enhanced more HT29-HER2 apoptosis and induced more cell cycle arrested in G1-S phase detected with FACS in vitro. …”
Publicado 2021
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102025por Kroll, Tina, Kornadt-Beck, Nikola, Oskamp, Angela, Elmenhorst, David, Touma, Chadi, Palme, Rupert, Bauer, Andreas“…This will complete a comprehensive appraisal of the animals’ welfare status in a retrospective manner and refine stressor procedures in the long run.…”
Publicado 2021
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102026por Araie, Makoto, Sugiyama, Kazuhisa, Aso, Kenji, Kanemoto, Koji, Kothapalli, Kalyani, Kopczynski, Casey, Senchyna, Michelle, Hollander, David A.“…Adverse events (AEs) occurred in a concentration-dependent manner, and the incidence of ocular AEs was 34.5%, 42.6%, 68.6%, and 9.1% in the netarsudil 0.01%, 0.02%, 0.04%, and placebo groups, respectively. …”
Publicado 2021
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102027por Grunddal, Kaare V., Diep, Thi A., Petersen, Natalia, Tough, Iain R., Skov, Louise J., Liu, Lingzhi, Buijink, Jesse A., Mende, Franziska, Jin, Chunyu, Jepsen, Sara L., Sørensen, Louis M.E., Achiam, Michael P., Strandby, Rune B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas M., Hjorth, Siv A., Bouvier, Michel, Cox, Helen, Holst, Birgitte“…Transepithelial ion transport was acutely affected by GPR39 agonism in a GLP-1- and calcitonin gene-related peptide (CGRP)-dependent manner. Analysis of Cpd1324 signaling properties showed activation of Gα(q) and Gα(i/o) signaling pathways in L cells, but not Gα(s) signaling. …”
Publicado 2021
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102028“…In the SAD and MAD (PIC formulation), tildacerfont concentrations declined in a multi-exponential manner with C(max) occurring moderately late, ~5 hours post dose, and a high degree of variability was observed in AUC and C(max) (CV range: 54–122%). …”
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102029“…Our studies revealed that NCX4040 inhibited the cell viability of BPH-1 and WPMY-1 in a dose dependent manner with IC50 predicted at 5µM and 2.5µM respectively. …”
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102030por Zhang, Dongyun, Hugo, Willy, Bergsneider, Marvin, Wang, Marilene B, Kim, Won, Vinters, Harry, Heaney, Anthony P“…Tumor cells clustered in an origin-dependent manner and all expressed POMC and TBX19. However, the gene signatures of silent and active corticotroph tumors differed in 3 major aspects. …”
Publicado 2021
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102031por Fleseriu, Maria, Jorgensen, Jens Otto, Yuen, Kevin C J, Hoybye, Charlotte, Mao, Meng, Kang, Jennifer, Song, Wenjie, Komirenko, Allison, Shu, Aimee D, Beckert, Michael“…At physiologic conditions, lonapegsomatropin releases fully active, unmodified somatropin via autocleavage of the linker in a controlled manner. The safety and efficacy of lonapegsomatropin have previously been evaluated in two phase 3 trials and one long-term extension trial in pediatric GHD. …”
Publicado 2021
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102032por Wang, Shou-Mei, Yang, Pei-Wei, Feng, Xiao-Jun, Zhu, Yi-Wei, Qiu, Feng-Jun, Hu, Xu-Dong, Zhang, Shu-Hui“…RESULTS: Compared with the control treatment group, apigenin significantly inhibited Huh7 cell proliferation, cell cycle, colony formation, and cell invasion in a concentration-dependent manner. Moreover, apigenin reduced tumor growth, promoted tumor cell necrosis, reduced the expression of Ki67, and increased the expression of Bax and Bcl-2 in the xenograft tumors of Huh7 cells. …”
Publicado 2021
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102033por Lopez‐Ramirez, Miguel Alejandro, McCurdy, Sara, Li, Wenqing, Haynes, Mark K., Hale, Preston, Francisco, Karol, Oukoloff, Killian, Bautista, Matthew, Choi, Chelsea H.J., Sun, Hao, Gongol, Brendan, Shyy, John Y., Ballatore, Carlo, Sklar, Larry A., Gingras, Alexandre R.“…Furthermore, HKi2‐treated ECs also triggered Akt signaling in a phosphoinositide 3‐kinase (PI3K)‐dependent manner, as blocking PI3K activity blunted the Akt phosphorylation induced by HKi2. …”
Publicado 2021
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102034por Winstone, Helena, Lista, Maria Jose, Reid, Alisha C., Bouton, Clement, Pickering, Suzanne, Galao, Rui Pedro, Kerridge, Claire, Doores, Katie J., Swanson, Chad M., Neil, Stuart J. D.“…We propose that the polybasic cleavage site allows SARS-CoV-2 to mediate viral entry in a pH-independent manner, in part to mitigate against IFITM-mediated restriction and promote replication and transmission. …”
Publicado 2021
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102035por De Gagne, Jennie C, Cho, Eunji, Yamane, Sandra S, Jin, Haesu, Nam, Jeehae D, Jung, Dukyoo“…Cyber means using electronic technologies, and incivility is a general term for bad manners. As such, cyberincivility refers to any act of disrespectful, insensitive, or disruptive behavior in an electronic environment. …”
Publicado 2021
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102036por Moubarak, Maya M, Chanouha, Nour, Abou Ibrahim, Najwa, Khalife, Hala, Gali-Muhtasib, Hala“…RESULTS: TQ alone inhibited cell viability in a dose-dependent manner at concentrations below and above the half-maximal inhibitory concentration. …”
Publicado 2021
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102037“…Our main aim is to show if the rise‐in‐cases proceeds in a gradual and staggered manner instead of soaring quickly then we can suppress the burden of the health system. …”
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102038“…CONCLUSIONS: This study shows that interactive learning environments might deliver resilience interventions in an accessible and cost-effective manner in formal education, potentially even in distance-learning conditions owing to the COVID-19 pandemic. …”
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102039por Tyrovolas, Stefanos, Giné-Vázquez, Iago, Fernández, Daniel, Morena, Marianthi, Koyanagi, Ai, Janko, Mark, Haro, Josep Maria, Lin, Yang, Lee, Paul, Pan, William, Panagiotakos, Demosthenes, Molassiotis, Alex“…CONCLUSIONS: The prospective space–time scan is an approach that low-income and middle-income countries could use to detect emerging clusters in a timely manner and implement specific control policies and interventions to slow down COVID-19 transmission. …”
Publicado 2021
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102040por He, Nana, Zhang, Yuelin, Zhang, Yue, Feng, Beili, Zheng, Zaixing, Wang, Dongjuan, Zhang, Shun, Ye, Honghua“…The study showed that plasma miRNAs changed in an aging-related sarcopenia manner and were associated with increased fracture risk. …”
Publicado 2021
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