“…RESULTS: All iron III forms including FAC efficiently blocked hepcidin mRNA expression at non-toxic dosages in Huh7 cells or primary hepatocytes in a time and dose-dependent manner (P < 0.001; P < 0.05). Hepcidin blockage could be efficiently blunted by iron chelators salicylaldehyde isonicotinoyl hydrazone (SIH) and Desferal (P < 0.001). …”
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“…This study aims to evaluate the ECP effect on VEGF-A, VEGFR-2, and miR-92a in patients with RA in a sham-controlled manner. Methods: This was a randomized sham-controlled trial, enrolling 50 patients with RA who have coronary artery disease (CAD). …”
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“…Finally, rescue experiments involving pharmacological or RNA interference-mediated inhibition of RAC1 or RAC1b, respectively, confirmed that both RAC1 isoforms control the deTDtP in an opposite manner. We conclude that RAC1 and RAC1b antagonistically control growth factor-induced activation of an endocrine transcriptional program and the generation of CSCs in quasimesenchymal PDAC cells. …”
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“…This method is open and extensible, and can be used in a high-throughput manner, easily allowing the addition of new mutation sites as needed to identify and track new SARS-CoV-2 variants as they emerge. mPCR-MS minisequencing provides a new detection option with practical application value for SARS-CoV-2 and its variant infection. …”
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“…HCPs were able to use the tool in a person-centered manner, as intended. For several people with diabetes, completion of the questionnaire facilitated positive reflection and better preparation for the visit. …”
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“…BACKGROUND: Leaf senescence occurs in an age-dependent manner, but the rate and timing of leaf senescence may be influenced by various biotic and abiotic factors. …”
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“…The recovery of lower limb coordination during swing phase illustrates what is possible when strength is sufficient and when coordination training is targeted in a carefully titrated, highly incrementalized manner. Conclusions/Contribution to the Field: This case study contributes to the literature in several ways: (1) illustrates combined interventions for gait training and response to treatment; (2) provides supporting case evidence of relationships among knee flexion coordination, swing phase coordination, functional mobility, and quality of life; (3) illustrates that strength is necessary, but not sufficient to restore coordinated gait swing phase after stroke in some stroke survivors; and (4) provides details regarding coordination training and progression of gait training treatment for stroke survivors.…”
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“…BCP was able to induce the apoptotic mechanism by activating the molecules involved in triggering apoptosis, such as Bax and caspase 3, and it reduced the anti-apoptotic protein Bcl-2; BCP also regulated cell proliferation through sophisticated crosstalk between Akt, β-catenin, and cyclin D1/CDK 4-6 in a concentration-dependent manner. These effects were counteracted by AM630, a CB2R antagonist, thus showing that BCP acts through CB2R. …”
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“…In a randomized, double blind, placebo-controlled, crossover, and counterbalanced manner, 13 healthy male and female participants were randomly assigned to consume a placebo (PLA) or 200 mg of PXN (ENFINITY™, Ingenious Ingredients, L.P.). …”
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“…RESULTS: The rs11453459insG variant genotypes (ins/ins+del/ins) of PPP2R1A were found to be significantly associated with an increased risk of PLC compared with the del/del genotype (adjusted OR = 1.290, 95% CI = 1.009–1.650), and the number of insert G allele worked in a dose-dependent manner (P(trend)= 0.007). The stratified analysis showed that the effects of rs11453459insG variant genotypes were more evident in the subgroup who drink pond-ditch water (adjusted OR = 3.051, 95% CI = 1.264–7.364) than those never drink (P = 0.041). …”
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“…RESULTS: Although social support, the most prevalent communication theme in both communities, was expressed in several subtle manners, the prevalence of emotions was higher in the tobacco cessation community and assertions were higher in the diabetes self-management (DSM) community. …”
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“…This work has the potential to improve future clinical research, as the text-extraction program shows promise in performing chart review in a more time-efficient manner, compared with the traditional labor-intensive manual chart review.…”
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“…RESULTS: Andro inhibited human NSCLC cellular proliferation and induced apoptosis in a dose-time or dose-dependent manner via activation of the mitochondrial apoptosis pathway. …”
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“…For the remaining 57 cases, the imaging was reviewed in the following manner. For the MRI studies, the report was read from the radiologist assessing the lateral ankle complex. …”
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“…The restorative materials were applied to all dentin surfaces according to the manufacturer’s instructions, using a special jig (Ultradent) in the following manner : Group 1 (Activa Bioactive Restorative with adhesive), Group 2 (Activa Bioactive Restorative without adhesive) and Group 3 (Filtek Z350 XT/Z350). …”
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“…In vitro, mAb8B6 suppressed proliferation and mammosphere formation and induced apoptosis of OAcGD2(+) breast cancer cells harvested from PDXs, in a dose-dependent manner. Finally, administration of mAb8B6 in vivo dramatically suppressed tumor growth of OAcGD2(+) breast CSCs (BCSCs) with complete tumor abrogation in 3/6 mice. …”
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“…This QI project was started to allow the Nile MDT to explore ways to reduce serious incidents on the ward in the least restrictive manner. We implemented a number of change ideas within this project. …”
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“…We developed a novel algorithm that identifies CD [Formula: see text] TAMs in an objective manner and quantifies spatial interactions between CD [Formula: see text] TAMs and cancer cells using distance-based metrics. …”
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“…Beyond the initial deformation due to the preloaded laxity, both hexapod frames responded to loading in a similar manner. There were significant differences in the frames’ mechanical behaviour under different loading conditions but further research is required to determine whether these translate in vivo into clinical significance. …”
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“…BACKGROUND: Patient-clinician secure messaging is an important function in patient portals and enables patients and clinicians to communicate on a wide spectrum of issues in a timely manner. With its growing adoption and patient engagement, it is time to comprehensively study the secure messages and user behaviors in order to improve patient-centered care. …”
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